Aquator has stolen a secret formula from a scientist who is friends with Big D and shrinks himself to microscopic size in order to get all the microscopic creatures to become large.

Plant Man thaws the last three prehistoric plants (the Carnivorous Chewer, the Creeping Crusher and the Fire-Breathing Snapdragon) from a glacier and then sprays them with his Obedience Ray in a plot to eliminate Buzz and Frankenstein Jr.

Professor Stretch causes havoc with his elastic abilities.

The Dragster has stolen a valuable item.

The Mad Inventor has invented the Double Identity Duplicator Projector to create living images he can control.

The Spinner returns and steals a priceless pooch.

The Surfer takes pictures of a top secret submarine.

The Junk Man creates the Colossal Junk Monster in a plot to eliminate Frankenstein Jr.

No description available

Spraysol steals top secret documents.

Buzz and Frankenstein Jr. guard the Navy's new Hydrotomic Submarine to prevent Dr. Hook and his aquatic monsters from stealing it.

The Sculptor turns people into statues.

The Archer steals a priceless violin and a million dollars.

Zorbo the Great creates a genie and plans to use its three wishes in order to defeat Frankenstein Jr. and conquer the world.

The Inflator creates giant balloon monsters to help him commit crimes.

The Diamond Dazzler steals a precious diamond in order to awaken the genie within.

Birdman and his robotic birds Vulturo, Rodantus, and King Condor abduct two astronauts and hold them for a ransom of $1,000,000.

The Paper Doll Man returns and causes trouble.

A witch named Cronella Critch robs a charity for orphans party.

Sertano the Satellite King, an alien from Galaxy X, uses a gravity ray in order to get Earth to surrender. Buzz and Frankenstein Jr. must defeat Sertano's robots in order to defeat him.

The Twister is stealing precious jewels.

Professor Stretch returns and creates a rubber monster to help him.

No description available

The Tapper transmits himself over phone lines.

The Angler steals secret space research.