In the premiere episode Piers Morgan interviews talk show host Oprah Winfrey.

Howard Stern is interviewed.

Dr. Condoleezza Rice, Former United States Secretary of State is interviewed.

Comedian Ricky Gervais is interviewed.

Actor George Clooney and his father Nick are interviewed.

Rudy Giuliani is interviewed on "Piers Morgan Tonight", and he tells Piers Morgan he may be more likely to run for President in 2012 if Sarah Palin does too. In a green room Q&A after the interview, Giuliani gave his take on the state of the New York Yankees...and the state of Piers Morgan at CNN. "We're going to need a pitcher," said Giuliani. "As a Yankee fan, I'm nervous." As for Piers' future at CNN, Giuliani was a little less nervous: "A very probing interview, wonderful engaging personality, I don't see any reason why he wouldn't succeed." Giuliani also gave his take on how to get Piers to stop with all the cricket conversation – take a trip to Yankee Stadium. "He can come with me, the biggest expert on baseball," he said.

Joel Osteen, Senior Pastor of Lakewood Church and his wife, Co-Pastor Victoria Osteen are interviewed.

Sisters Kim and Kourtney Kardashian are interviewed.

The first in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporters include CNN Correspondents Nic Robertson, Ben Wedeman,Wolf Blitzer, John King, Amir Ahmed, Fran Townsend and Mohammed Jamjoom. Other guests are Steven Cook (Senior Fellow, Council On Foreign Relations), Frank Wisner (Former U.S. Ambassador To Egypt),Richard Grenell (Former U.S. Spokesperson to the United Nations), Robin Wright (Former Middle East Correspondent), Mark Coatney (Director, Tumblr) and Egyptian Journalist Sarah Sirgany.

The second in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporters include CNN Correspondents Anderson Cooper, Ben Wedeman and Nic Robertson. Guests appearing on the program are Christiane Amanpour, (ABC'S This Week), Prince Reza Pahlavi (exiled son of the Shah of Iran), Dan Rather (HD Net), Mohamed El-Erian (CEO of the world's largest bond fund manager, Pacific Investment Management Company (PIMCO)) and Mohamed Elbaradei (a leading opposition figure).

The third in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Piers interviews Former British Prime Minister Tony Blair and former Republican Presidential Candidate Mitt Romney. CNN's Anderson Cooper and Nic Robertson and Nicholas Kristof of The New York Times report on the crisis. A breaking news segment with CNN meteorologist Rob Marciano, located in Chicago, on a massive winter storm with the potential to cut a 1,500 mile swath of heavy snow, ice and bitter cold across America and affect 100 million people is also presented.

The fourth in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. CNN Correspondents Anderson Cooper, Ivan Watson and Hala Gorani report. Former Mayor of New York Rudy Giuliani and Barbara Walters of ABC News and The View are interviewed on the crisis. Barbara also discusses a variety of topics, including having had open heart surgery.

The fifth in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporting are CNN Correspondents Anderson Cooper, John King, Nic Robertson, Fionnuala Sweeney and Peter Bergen. Other reporters are Nicholas Kristof (The New York Times), Sarah Sirgany (Daily News Egypt/International Herald Tribune), Mort Zuckerman (Editor In Chief U.S. News And World Report) and Martin Peretz (The New Republic).

The sixth in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporters include CNN Correspondents Anderson Cooper, Wolf Blitzer and Ivan Watson. Tunisian Prime Minister Mohamed Ghannouchi (via a tanslator), Egyptian Finance Minister Dr. Samir Radwan (via telephone), Christiane Amanpour of ABC News, Sarah Sirgany of the Daily News Egypt/International Herald Tribune, Atlantic Council Chairman Chuck Hagel and Former Homeland Security Secretary Michael Chertoff are interviewed on the crisis.

Actor Anthony Hopkins is interviewed.

Angie Dickinson, Linda Evans, Stefanie Powers and Nichelle Nichols are interviewed.

The seventh in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporters include CNN Correspondents Ivan Watson, Fareed Zakaria and Anderson Cooper. Nicholas Kristof of The New York Times and Senator Bill Nelson (D) of Florida are interviewed on the crisis. Her Majesty Queen Noor of Jordan, Chair of King Hussein Foundation is interviewed on the crisis and a variety of other subjects. Lastly, Arianna Huffington and AOL CEO Tim Armstrong, are interviewed on AOL's $315 million purchase of the Huffington Post.

Actors and twin brothers Cameron and Tyler Winklevoss from the film Social Network and NFL football player Michael Oher are interviewed.

In the first program before a live studio audience, Donald Trump is interviewed. A report on the sudden resignation of New York Republican Congressman Christopher Lee three hours after a report that he sent a shirtless photo of himself to a woman who wasn't his wife is also presented. Maureen O'Connor of the web site Gawker, who broke the story, is interviewed.

The eighth in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporters include CNN Correspondents Ben Wedeman, Ivan Watson, Wolf Blitzer, John King and Arwa Damon. Sarah Sirgany (Daily News Egypt/International Herald Tribune), Christiane Amanpour (ABC News' This Week), Sameh Shoukry (Egyptian Ambassador To United States), John Negroponte, (former United States Ambassador to Iraq), Paul Wolfowitz (former Deputy Secretary of Defense), General Richard Myers (former Joint Chiefs of Staff Chairman), Reza Aslan (author of No God But God), journalist Robin Wright, Rafat Ali (Founder of Paidcontent.org) and Aladdin Elaasar (author of The Last Pharaoh) are interviewed on the crisis.

Live from London, England, the ninth in a series of programs on the remarkable events in Egypt leading to the stepping down of President Hosni Mubarak. Reporters include CNN Correspondents Nic Robertson, Arwa Damon, Ben Wedeman and John King. Sarah Sirgany (Daily News Egypt/International Herald Tribune), Samir Radwan (Egyptian Finance Minister (via telephone)), Bill Richardson, (former United States Ambassador to the United Nations, former Energy Secretary and former Governor of New Mexico), Zalmay Khalilzad (former U.S. Ambassador to the U.N.), Bob Baer (former CIA Officer), Paul Wolfowitz (former Assistant Secretary of Defense), Jane Mayer (The New Yorker), Maha Azzam (Associate Fellow, Chatham House) and Zvi Mazel (former Israeli Ambassador to Egypt) are interview on the crisis.

Donny Deutsch, host of Bravo TV's Love Calling and Phaedra Parks, Kandi Burruss and Nene Leakes of The Real Housewives of Atlanta are interviewed.

Janet Jackson is interviewed.

Marine Corps veteran Anu Bhagwati, Executive Director of the Service Women's Action Network and Rebekah Havrilla and Myla Haider, military members and plaintiffs in a lawsuit against Defense Secretaries Gates and Rumsfeld as interviewed. Rebekah and Myla tell their stories of sexual abuse while in the military. Also, Cheryl Burke of Dancing with the Stars is interviewed on overcoming her childhood trauma and abuse, which she discussed in her book Dancing Lessons.

Colin Firth, Geoffrey Rush, Helena Bonham Carter, Academy Award nominated stars of the film The King's Speech are interviewed.