When a young Arizona businessman is found slaughtered in his bathroom, friends point police towards his on-again off-again ex-girlfriend. Facing the death penalty, Jodi Arias takes the stand for an unprecedented 18-days in an attempt to explain how the brutal killing of her ex-boyfriend was self-defense.

When an off-duty Dallas police officer shoots a man in his own apartment, the jury will have to decide if it was murder or a tragic mistake. Amber Guyger takes the stand in her own defense to convince the jury not to lock her away for up to 99 years.

When a parolee is bounced from his job, he seeks retribution on a peaceful, unwitting community when he kidnaps, tortures and kills a mother and caregiver. Scott Nelson takes the stand to give a convoluted explanation on why he blames his parole officer for his seemingly random decision to kidnap, torture and kill a local Florida woman.

Shayna Hubers takes the stand to defend herself after she brutally murdered her on-again, off-again boyfriend, Ryan Poston. She willingly takes the stand to prove her actions were in self-defense, by showing Ryan's abusive side.

A shootout with police in West Virginia leads to the arrest of a 23-year-old Texas man, who is charged with savagely killing an elderly couple, robbing them and burning down their home. Facing the death penalty, the defendant decides to take the stand and points the finger at the surprising suspect he claims committed the horrific crimes.

Former Houston doctor Leon Jacob is currently serving a life sentence. He was found guilty of plotting, along with his girlfriend, Valerie McDaniel, the murder of his ex-girlfriend and Valerie's ex-husband. Valerie took her own life after serving some time in prison. Leon Jacob takes the stand to defend his rocky past.

Sean Foley stands accused in the shooting death of his girlfriend's step-father, Jimmy Shelton. After a booze-filled evening, Sean fatally shoots Jimmy on Jimmy's own back porch. Sean claims that Jimmy was the aggressor that night. Foley has decided to take the stand to convince the jury that he's innocent, that the shooting was in self-defense and not cold-blooded murder.

When railroad mechanic Robert Limon is shot and killed by Jonathan Hearn, an investigation leads to Robert's widow--and spurs questions about her involvement in the crime. Sabrina Limon takes the stand to contest the account of her former lover, Jonathan Hearn, insisting she had no knowledge of his intent to commit the crime.

When a university student and athlete is stabbed to death following a minor traffic incident, a 24-year-old fast food worker is indicted on a second-degree murder charge. Luke VanHemert takes the stand to address inconsistencies in his story to police, and to claim his actions were in self-defense.

George Burch stands accused of the brutal murder of Nicole VanderHeyden, a 31 year old mother of three. He willingly takes the stand to prove he is not guilty and provide the jury with an alternative suspect.

When a son finds his father slumped over dead near a pile of cocaine, he dismembers the body to conceal the crime; James Scandirito Jr. takes the stand to explain why he thought he had to dismember and bury what he claimed...

A beloved college professor is executed in Tallahassee, Florida and the suspects include a mother with two children, a violent gang member and a family of wealthy dentists.

When a woman shoots her pilot husband and flees to Brazil, she sets off a long battle for her extradition and trial in the States.

What started out looking like a freak traffic accident soon becomes a suspected murder cover-up. Todd Kendhammer has to take the stand to convince a jury that he would never hurt the love of his life, his wife ...

When 3-year-old Hannah Wesche dies of head trauma, the babysitter who cared for her is indicted for her murder.

A routine response to a noise complaint takes a devastating turn when Roy Oliver, a Dallas police officer, shoots and kills unarmed 15-year-old Jordan Edwards.

A couple from a small Ohio town are charged with eleven felonies, including the deaths of their infant son, whose injury riddled body was found in a well.

An Iowa pig farmer stands accused of impaling his wife with a corn rake. The jury has to decide if it was cold-blooded murder or a tragic accident; Todd Mullis takes the stand in his own defense.

When a young mother and her three children are brutally murdered in their suburban Florida home, an ex-boyfriend is charged with the killings. The jury has to decide if this was a crime of passion or a professional hit.

20 year old Heather Elvis went missing on December 18, 2013 and has never been found. Tammy Moorer, Heather's boyfriend's wife, is on trial for her kidnapping.

Zachary Wester, a Sheriff Deputy from Jackson County Florida, stands accused of planting drugs on unsuspecting motorists during routine traffic stops. He's been charged with over 65 counts and faces up to 85 years in prison if found guilty. Will he be able to convince a jury his stops were by the book or will he be guilty of betraying the badge and the community he served?

During a road rage incident, Theodore Edgecomb shoots and kills predominant immigration lawyer Jason Cleereman. Charging him with 1st degree intentional homicide, the state contends it was a cold-blooded murder. Edgecomb has decided to take the stand to convince the jury he shot Cleereman in self-defense. Will the jury believe him and spare him from life in prison?

Richard Acosta, Jr. is being tried for murder, accused of being the getaway driver for his son.

Hannah Payne is on trial for the murder of Kenneth Herring, a motorist who fled an accident.

In 2006, Ken Juedes was found dead by his wife, Cindy Shulz-Juedes. For 13 years the case went cold until investigators linked her to the murder. Cindy Shulz-Juedes has decided to take the stand with the hope of convincing the jury she is innocent, and her husband's real killer is still at large.