On the night of Marti Gras, Remy finds himself held hostage at his hangout, the Blue Spot Bar, by an escaped convict, named Lyle Tillman (Silas Weir Mitchell), who seeks to prove his innocence of a murder-robbery the previous year while Lyle's very pregnant wife, Grace, holds C.D. hostage in his office at the police station as another bargaining chip leading to Darlene (stuck wearing a Little Bo Peep costume) as well as Anne (stuck in a Marie Antoinette costume) to try to help defuse the situation while Smiley finds himself the errand boy between the two standoffs while Hawkins assembles a group of SWAT men (stuck in clown costumes) to plan a brash assault on the bar in spite of the situation.

Remy investigates the murder of a prominent, but debauched lawyer on a tram street car where he tries to link a mysterious blond waitress to an exterminator company that the lawyer represented sometime back. Meanwhile, Remy is not too pleased when he is paired with a new trainee, the ambitious, but naive Janine Rebbenack who transfers to the squad, and she quickly annoys Remy with her by-the-book ways of handling the case. Elsewhere, Smiley asks Remy for financial assistance as he prepares to open up his own jazz and blues club.

Remy is approached by a young woman, named Eve Davenport , who claims to be looking for her missing sister which is connected to the discovery of a body in the delivery van driven a half-witted old friend of Remy's named Joey LaVern, who claims to be working for a shady coffee manufacturer whom is seeking a large sum of stolen money that someone took from him.

Remy and Janine team up with a shady, alcoholic Russian agent whom is in New Orleans looking for a missing challis which was stolen from a local Russian Orthodox church resulting in the murder of the caretaker. But there's more complications when an equally shady female American Interpool agent, named Mariel Rigg, also arrives looking for the challis and has her own agenda.

Remy becomes acquainted with a former police academy friend, named Tony, while investigating the murder of a high-stakes gambler shot by a sniper though his apartment window in which a local street musician, named Peter, finds himself the only witness to the crime and who also has a crush on the murder victim's fiancée, while Remy thinks that a gambler friend of the murder victim may be the next target.

Remy, Janine, C.D. and the team investigate the shooting spree at a local restaurant where the owner apparently died from sheer fright. But when Remy learns that the victim was in fact poisoned, he sets out to find the culprit. This leads him from the shooting culprit, Angela, whose father was in competition with the murder victim, which leads to a shady produce entrepreneur, whom was in feud with the victim.

Smiley becomes reacquainted with his former flame Cassandra, a gospel/blues singer, whom is the suspect in the murder of a record company mogul that Remy is investigating. When evidence clears Cassandra, Remy puts his focus on other suspects whom include the doorman LaRue as well as a Cassandra's sleazy manager, Dominick, in which Janine decides to go undercover to look for evidence against him.

A mysterious woman leaves her infant child on the steps of the police station with a note claiming that the baby is Remy's. He is stuck with the infant while Janine, Smiley, C.D. and others takes turns looking after it as he goes out to look for the birth mother. He thinks the mother of the child might be connected to a murdered man found behind the station house.

When a bomb explosion at a local health club kills a patron, Remy and the team must find the bomber before he strikes again. But when Janine is taken hostage by the bomber after she accidentally stumbles onto his identity, Remy must race against the clock to find her as well as the bomber's identity, with the help of Smiley's psychic friend Zoey, before he can detonate a much larger bomb, while the captive Janine must try to survive the bomber Luke's physical and mental mind games.

Remy investigates the murder of a truck driver in a suspected hijacking of a fish truck containing several pounds of illegal shrimp for distribution. But Remy begins to focus more on the owner of the seafood wholesaler, Kristen Mullen, whose company is facing bankruptcy. Meanwhile, Smiley deals with a young Japanese woman, named Yuki, who arrives at the Blue Spot claiming to be his new mail order bride that one of his regular customers ordered in his name.

Investigating the hit-and-run of a teenage transient, Remy asks Janine to go undercover as a fellow street person to keep an eye on a young teenage runaway, named Maura, whom stumbled upon a mysterious black duffel bag containing $25,000 in cash and who may be targeted by the shady thug whom is connected to a larger plan. Meanwhile, Smiley continues to deal with Yuki running the Blue Spot in her own way. When Yuki decides to return home to Japan, but does not have the money to go back, Smiley decides to throw farewell party for her as part of a fund-raiser for the blue musicians of the area.

Remy investigates the mysterious death of a businessman whom he believes it to be the work of voodoo. While everyone, but the skeptic Anne, believes in the local voodoo superstitions, Remy sets off with Smiley to find the right culprit, while Anne decides to try out an experimentation to see if it really exists by concocting a "love potion" for Remy to notice her.

Remy begins moonlighting as a personal bodyguard to a wealthy shipping magnate when his life is threatened. But Remy cannot resist temptation to the rich guy's young wife, Isabella, while leads point to a sordid state of affairs involving a prenuptial agreement, and the man's first jealous wife. Meanwhile, Anne asks Smiley to go undercover to investigate Isabella's past involving her shady "brother" Martin connected to a local pimp who may hold a clue to the case. Elsewhere, Darlene struggles to run the station house in the absence of several officers on leave.

Remy is kidnapped by three female escaped convicts whom force him to help them look for a half-a-million dollars in cash from a bank robbery in which Remy must try to use his seductive charms to stay alive long enough to stall for time while the ringleader of the female trio, another ex-con named Cyrus St. John holds a grudge against Remy for putting him away years earlier.

Detective Remy McSwain is a brash, womanizing, and unconventional New Orleans police detective who doesn't always play by the rules in order to get criminals locked up. But with the help of his uncle C.D. LeBlanc, the police chief and a fanatic Civil War buff, and Remy's man-hungry detective partner, Darlene Broussard, he always manages to stay one step ahead of the law. But everything changes with the arrival of Anne Osborne, a district attorney from Washington DC whom is sent to oversee a case of illegal fishing in the remote bayous where Remy is investigating a murder which may lead to a high-up power in the city council. Anne finds herself captivated by the intense good/bad cop who tries to gain her affections with the help of his street informant and blues musician Smiley Dupree, while the local district attorney, Lightnin' Hawkins, persuades Anne to get close to Remy in order to nail him on a corruption probe the city is putting on.

Anne's fiancée, Geoffrey Stodermayer, a marine biologist, arrives in town to set an upcoming date for their wedding in which Remy drags him into his latest case of investigating a shady strip club owner's liquor imports in which Geoffrey develops an attraction to Gigi, an informant who works at the Naked Angel exotic club and is soon put in jeopardy by the thugs out to silence her and anyone else who informs on them.

As Anne settles in New Orleans (aka: The Big Easy) to stay, Remy continues to try to win her affections with the help of Smiley and his other associates, while both Anne and Remy have fantasies about the other, while Lightin' Hawkins also tries to get Anne to notice him as well. Meanwhile, a fortune-telling friend of Remy's, named Zelda Riley, tells him about a premonition about a street informant being murdered. Remy investigates and soon locks horns again with Anne who suspects Zelda somehow being involved, while Remy thinks otherwise and sets out to prove it.

Remy investigates the murder of a groom at his bachelor party where the only evidence is that of a high-heeled shoe left behind by the killer who may have been a transvestite. In attempting to dig into the past of the murder victim, Anne also learns some hidden facts about the groom's real interests as well as the bride-to-be's urges. Elsewhere, C.D. tries to find time to help Remy with his investigation while planning to hold another Civil War re-enactment outside of town.

While investigating the death of a wealthy businessman who died from a fall at a house reputed to be haunted, Remy and the team try to disapprove of the theory that the ghost of a scorned woman is behind it who shows up to murder three men every seven years. While Remy deals with a persistent female reporter, whom he once had a tryst with, Anne volunteers to go undercover at a local escort service to look for clues, while Smiley decides to moonlight at a taxi driver only to have his uncle's cab damaged by another falling victim.

The discovery of a dead drug dealer in the car truck leads to the arrest of an attractive blond, named Grace, who claims that she was framed. Remy thinks that Grace is hiding something about a romantic connection to a hopeful senatorial nominee whom is being blackmailed by an unseen third party. Remy discovers that by trying to uncover the blackmail scheme involving Grace, the political candidate Francis Hurley, and Grace's boxer older brother may lead to a political scandal the city may not be prepared for. Meanwhile, Smiley becomes angry when Remy cancels their annual fishing trip in order to concentrate on the case, while Janine continues to deal with the unorthodox Remy's handling of the case his way.

Remy investigates the death of the father of a young debutante in a suspicious plane crash in the swamps and learns a series of facts about the unscrupulous businessman, including the fact that C.D. was romantically involved with the widow of the victim. Meanwhile, Anne, with Darlene's help, strikes out on her own investigation into the mysterious death by trying to establish a motive by either the debutante daughter Alana, or the estranged artist son Kent .

In the retrospective season final, Remy and Anne are abducted by a pair of redneck brothers whom Remy put away their serial killing eldest brother, leading to the mismatched detective and attorney trying to get away from their would-be killers by hiding out deep in the swamps where they reminisce about their happier and more harrowing times. Meanwhile, C.D. and Smiley figure out that Remy and Anne are in trouble when they go missing and try to find them before the Bill Brothers have their chance to lynch them.

While investigating the murder of a philandering fiancée on the eve of his wedding, Remy becomes acquainted with a former flame, a police psychologist named Dr. Wanda Fallon, who wants in on the case which she thinks is the work of a serial killer. Despite that nobody, but Remy, trusts Wanda, he must take it on himself to find the killer as well as a mysterious scruffy man following him who may be connected to a local tarot reader who may hold a clue.

Remy, Anne, and C.D. are approached by a young policewoman and Civil War buff to help her investigate the murder of her friend who was allegedly trying to track down alligator poaches in the bayous. While Remy begins to think there is a connection between a bar owner who operates without a liquor license, Anne and Officer Joyce get stuck in a tree to get away from an aggressive alligator, while Joyce persuades C.D. to let her join his reenactment group. Also, Smiley tries to find more work to write while he continues his music career.

Remy tries to help out his old friend Delbert, a gambling addict, whom is heavily in debit to a local mobster. But when a treasury agent is found murdered at the casino boat where Delbert hangs out, Anne learns that he has been investigating Remy at the behest of Hawkins, while the leads that Remy follows point to the casino owner who is involved in a counterfeit operation and he asks Anne to pose as bait to entrap the owner.