Tim receives a strange message, launching a larger investigation into the dark web. Meanwhile, Celina works to take down a popular podcast, and Miles helps update the department’s training videos.
When multiple patients throughout the hospital begin to show similar, alarming symptoms, Sharpe and Bloom scramble to figure out the root of the issue. Iggy tries to create peace for a divorced couple in a dangerous situation and Kapoor experiences a flirtatious encounter. Meanwhile, Max meets a child with a rare muscular disease and desperately tries to get him into the only clinical trial in the country that could extend his life.
Asher's views on the construct of marriage complicate his future with Jerome. Meanwhile, Asher also briefly revisits his religious past to aid a patient's conversion to Judaism for his fiancée.
Max and Bloom are shocked when a deadly ambulance crash reveals a dangerous plan. Dr. Fuentes pressures Iggy to take on patients. Sharpe realizes her own cost-cutting has adversely affected her department. Reynolds, Baptiste and Malvo strive to reach an accord.
"C.R.E.A.M." is the best rated episode directed by Dinh Thai. It scored 9/10 based on 2 votes. It was written by N/A. It aired on 10/20/2021 and is rated 0.0 points higher than their second-best episode, "Visionz".