Cole's search for the location of the virus leads him to 2014, and to a devastating moment in Dr. Railly's life involving a dangerous outbreak in Haiti.

The trail of a mysterious organization called the “Army of the 12 Monkeys” leads Cole to a mental institution in 2015, where a patient holds the key to the plague that destroys the world. Meanwhile, despite warnings that her involvement may disrupt the course of history, Dr. Railly risks her life to help him.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threatens the mission to save the past.

While searching for Jennifer Goines in post-WWI France, Cole and Jones encounter a dangerous group of time- travelers - the Guardians.

When the tragic events of the Night Room create an alternate reality in 2043, Cole risks his future.

Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.

Former friends, now enemies, race to find the Witness in 1904, who, at last, reveals his face.

The final conflict with the Army of the 12 Monkeys begins when the Witness returns to Project Splinter.

Forces come to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.

With the temporal facility on the verge of destruction, Cole and Jones find themselves in the middle of a coup. After a violent encounter ends in an unexpected tragedy, Cole is sent back to 1957 in a last-ditch effort to save humanity while the rest embark on a caravan across the apocalypse to find Titan -- the stronghold of the Witness.

27 years after a virus wipes out most of humanity, scientists send a man back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist, who knows the dangerous source of the outbreak.

Cole and Dr. Railly face off with the Army of the 12 Monkeys when both discover the Night Room –- an off-site, black ops lab that houses the virus that will one day destroy the world.

Cole, Dr. Railly and Aaron strive to stop the virus from being deployed as a bioweapon in Chechnya.

The Core that powers the time machine is fading. To get Cole back from the past, Jones must convince her former colleagues at the military operation "Spearhead" that her mission is worth saving.

With Cole dying from the effects of time-travel, Railly must find the one person who can save him.

Cole and Ramse repair their broken friendship while on the run; Railly and Jones navigate an uncertain future in 2043.

Cole and Railly attempt a final confrontation with their closest enemies, while Jones faces a new threat to all that she's accomplished.

In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.

Cole splinters to Tokyo, 1987 in a last chance effort to stop the Army of the 12 Monkeys.

Despite the growing tension between them, Cole and Cassie time travel to New York during World War II to track down a dangerous member of the Twelve.

Bonds of trust are tested when Ramse returns to the facility with an old enemy held captive. How far will Cole and Jones go for the answers they need?

Out of time and in need of answers, Jennifer and Deacon are sent to 1989 to steal the a sacred document. Can Railly and Cole get to the Word first before it reveals the one secret they want kept?

The team infiltrates a Nazi gala to steal an artifact known as 'Die Glocke'. Their operation comes undone when French Resistance interferes and an unexpected guest arrives.

In the present, Cassie and Jennifer Goines run from the 12 Monkeys; in 2044, Cole and Ramse face off against Deacon.

Cole and Ramse travel to 1970s New York City to prevent the Twelve from murdering a Vietnam veteran with a connection to the Witness.