Cole's search for the location of the virus leads him to 2014, and to a devastating moment in Dr. Railly's life involving a dangerous outbreak in Haiti.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threatens the mission to save the past.

The trail of a mysterious organization called the “Army of the 12 Monkeys” leads Cole to a mental institution in 2015, where a patient holds the key to the plague that destroys the world. Meanwhile, despite warnings that her involvement may disrupt the course of history, Dr. Railly risks her life to help him.

The Core that powers the time machine is fading. To get Cole back from the past, Jones must convince her former colleagues at the military operation "Spearhead" that her mission is worth saving.

Forces come to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.

27 years after a virus wipes out most of humanity, scientists send a man back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist, who knows the dangerous source of the outbreak.

Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.

Cole and Dr. Railly face off with the Army of the 12 Monkeys when both discover the Night Room –- an off-site, black ops lab that houses the virus that will one day destroy the world.

When the tragic events of the Night Room create an alternate reality in 2043, Cole risks his future.

Cole and Ramse repair their broken friendship while on the run; Railly and Jones navigate an uncertain future in 2043.

To save the last Primary, Cole must turn to a mortal enemy. Plus: Jennifer Goines, radical revolutionary?

Cole gets stranded in 2016 after an attempt to destroy the virus changes the future. Jones and Railly deal with the consequences of the changed timeline.

Despite the growing tension between them, Cole and Cassie time travel to New York during World War II to track down a dangerous member of the Twelve.

In the present, Cassie and Jennifer Goines run from the 12 Monkeys; in 2044, Cole and Ramse face off against Deacon.

Cole and Ramse travel to 1970s New York City to prevent the Twelve from murdering a Vietnam veteran with a connection to the Witness.

Cole has his loyalty tested when Ramse and Railly go rogue, embarking on an unsanctioned mission that sends them to 1961 East Berlin. Once there, they have murder on their minds as they search for an unscrupulous German doctor who knows the location of "The Witness."

Bonds of trust are tested when Ramse returns to the facility with an old enemy held captive. How far will Cole and Jones go for the answers they need?

The final conflict with the Army of the 12 Monkeys begins when the Witness returns to Project Splinter.

Travelers come face to face with ghosts from their past when they find themselves maneuvering around their own timelines.

Cole, Dr. Railly and Aaron strive to stop the virus from being deployed as a bioweapon in Chechnya.

Cole splinters to Tokyo, 1987 in a last chance effort to stop the Army of the 12 Monkeys.

When Cole and Cassie are stranded in 1944, Jones must turn to the person she trusts the least to bring them home -- Ramse. For Ramse, this mission will give him a chance to atone for his sins -- but can he mend the broken relations between Cole and Railly? Meanwhile, Jones visits Old Jennifer Goines to explore the true nature of Time - and the Twelve’s method to destroy it.

Cole faces the Witness as Cassie's hallucinations evolve; deadly visitors from the past arrive when the time machine malfunctions and begins tearing apart time and space.

In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.

While searching for Jennifer Goines in post-WWI France, Cole and Jones encounter a dangerous group of time- travelers - the Guardians.