Webster High is completely deserted due to the teachers getting food poisoning from the cafeteria. The ANT's are the only ones at school, and instead of attending class, Principal Skidmore sends them on an educational scavenger hunt around San Francisco. After Chyna and Lexi are chosen as team captains, they pick their teams, and head off. Now, both teams compete to see who comes out victorious.

Lexi decides to have a sleepover party and not invite the ANTs, so Chyna invites Olive to sleep over at her house.

When Dixon breaks up with Olive for another girl, Chyna tries to cheer her up.

The ANTs are in charge of arrangements for the school dance. Fletcher and Chyna go together so Fletcher doesn't have to go with Violet. Meanwhile Chyna and Olive pretend Fletcher's dead to raise money for the dance by selling his paintings. Cameron looks for a date to the dance, and finds a girl who apparently likes him, too, but it turns out she was imaginary.

Chyna, Olive, Fletcher, Angus and Lexi audition for an exclusive school.

Chyna is overheard singing by pop superstar Madam Goo Goo, and is totally star-struck when she is given Goo Goo’s phone number so they can work together on a song. However, when the ANTs go on a field trip to a fortune cookie factory, Chyna realizes she lost Goo Goo’s number. So Olive, Fletcher and Angus help retrace Chyna’s steps back to the factory to find the misplaced number. Meanwhile, Lexi finds out she wasn’t invited to a fellow cheerleaders birthday party.

Chyna and Fletcher go on a double date together. Meanwhile, Gibson takes over as cheerleading coach

A baby named Sebastian, thought to be a prodigy, is left in the care of the A.N.T.s and Chyna, Olive, Violet, and Fletcher try to uncover the baby's prodigal aptitude. They try art, music, karate, etc. Skidmore entrusts them to find its talent. But actually this was a trick Skidmore played on the ANTs.

The ANTs go to an Australian ANT convention. Coincedentally, Lexi and Paisley went to Australia for vacation, but were stuck at the ANT convention. At the convention, Chyna sees an Australian Nature prodigy named Neville, who has a show, where his name was Tazmanian Neville. Fletcher wants to prove that he has "manly skills", so he asked an Australian supervisor, who dropped him off in the middle of the Australian Outback. Chyna, Olive, Angus, and Neville go to save him, but then learn that Neville is actually an Acting prodigy, who knows nothing about nature. Olive suggests to throw a boomerang to hunt birds, but it doesn't work. Chyna suggests to crack "rocks" together to make fire, but the "rocks" were actually emu eggs. Later on, the 4 of them hide in an old car, when they discuss how much they miss Fletcher. Just when they thought Fletcher was not ever coming back, they saw him riding on an emu. Chyna starts to tell Fletcher that she'd might actually- Just then, the boomerang came back and hit her on the head. Meanwhile, Lexi and Paisley dress up as nerds and participate in the ANTlympics.

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Chyna is extremely happy to find out that Olive and Fletcher are now dating.

The ANTs take the IQ test; Olive is devastated when Chyna scores higher. Olive retests to receive a higher score, but she doesn't do so well. Olive decides to dumb herself down and starts acting like a dumb blonde. The next day, she has transformed into a mini Paisley, acting just as clueless as her. Meanwhile, since Chyna got the highest IQ score in the entire school, Principal Skidmore chose her to represent Webster High in the Acadecathalon. Chyna is completely lost, so Olive steps in and takes her place. It is revealed that Angus hacked into the school computer and messed with Olive's IQ test results to lower her self-esteem to finally go out with her. Elsewhere, hoping to be excused from P.E., Lexi and Cameron train to compete in curling in the Olympics with Gibson and Violet.

Chyna and the ANTs are tasked with creating a special project for Black History Month. As Chyna struggles to write a song for her presentation, she decides to lock herself in a recording booth until she comes up with a great song. After accidentally falling asleep, Chyna takes a dream journey back in time where she becomes famous African American music icons from the past, Ella Fitzgerald, Aretha Franklin, and Janet Jackson. Using her dream as inspiration, Chyna writes a new version of the A.N.T. Farm theme song "Exceptional" with lyrics that pay tribute to the great women who came before her.

Chyna lands the lead in the school musical, but jealous Lexi tries to sabotage the show. Meanwhile, Cameron learns that a teacher is living at school and offers to rent his family's living room to the man.

Violet, a sports prodigy with slight anger issues, joins the A.N.T. Program. Violet is not afraid of the older kids, including Lexi, who orders Chyna to keep the girl far away from her. Meanwhile, some of the older students take a drivers-education class.

A teen movie sensation Sequoia Jones who is playing the role of a tween musical prodigy and follows Chyna around to study for her role. But then, Chyna learns Sequoia is trying to steal her life.

After creating a really sad animation, Chyna advises Fletcher to do an animation on something he's familiar with, so he creates an offensive animation about Olive, making her an ant named "Pimento". It gains major popularity, and Olive is majorly offended, so she tries to offend Fletcher back, but that doesn't work out so well. After Olive issues a lawsuit on Fletcher for offending her, they go to student court, where they learn to be friends again, and start teasing Chyna. Chyna takes it okay, so they all hug and make up. Cameron joins the beauty club to keep Vanessa away from other boys, but things go horribly wrong.

Chyna's grandmother visits. Skidmore retires, and she is the new principal, Chyna is happy at first but later she turns the school into a madhouse, so Chyna, Olive, Fletcher, and Angus try to get Skidmore out of her retirement.

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Chyna and the ANTs face a crisis when defects with the zPhone cause customer issues.

Everyone accompanies Zoltan to the opening of the new flagship Z-Store in NYC. Chyna connects with a street performer named Hudson, who puts on a tough guy persona to impress her. Meanwhile, Fletcher gets the opportunity to move to NY as an artist in residence at a museum.

11 year old Chyna starts her first day at High School as part of the Advanced Natural Talents (ANT) Program. There she meets Olive (who is smart) and Fletcher (who is a good artist and has a crush on Chyna). Chyna's two new friends help her learn the ropes of her new school. But, Chyna of course doesn't fit in. So, she decides to sneak into a party and show the High Schoolers what shes got. But, Olive, Fletcher and Cameron (Chyna's brother) might ruin her chances.

Olive is shocked to discover that her pet robot, Hegel, is no longer functioning and has suspicious screwdriver scratches on his back. When a screwdriver is found in Chyna's locker, Chyna suspects that she has been framed and vows to find the real culprit. In the end, it is revealed that Chyna accidentally overfed Hegel.

Chyna helps Cameron track down the model who he imagined was his girlfriend. Chyna, disguised as a model agent, gets Vanessa to date Cameron. Vanessa wants to go on a picnic in a hot air balloon. Lexi gets a new job at Hippo's new restaurant.

Chyna accidentally convinces her father, Darryl, to quit his job after he tells her much he hates it. Darryl tries finding other suitable jobs, but it is no use. Chyna does not like seeing him depressed, so after she witnesses him track down the remote control very cleverly, she tells him to work as a private investigator. Plus, Chyna creates a fake crime scene at school to get his business started. Meanwhile, Lexi is horrified when she realizes that she and Paisley have the same amount of friends on Wolf Pack, a popular social network. After finding out that Cameron just signed up to Wolf Pack, they try to compete over whose friend request he should accept first in order to obtain more friends.