John travels to and through the Great Plains to find out where wild and domestic cats occupy the same sanctuary and to learn who is the most popular cat on television in Little Rock, Arkansas.

In this stop on the Must Love Cats tour, John explores the Midwest to uncover how the most popular comic strip kitty was born as well as whether a cat with four ears can hear better than the average feline.

The Northeast packs a punch for John Fulton and his feline friends as he explores the birthplace of the beloved domestic shorthair cat and finds out how New York City cats earn their keep.

Back on the road, John continues his journey around the country in the Southwest where he meets felines with frontier flair. Everyone knows that everything is bigger in Texas, and it's no different for Texan cats! Then it's on to New Mexico for a stop at Kitty City before finishing things up in California.

Touring the southeast, John travels into the foothills of the Smokey Mountains in North Carolina, home to a heroic cat named Leroy and a team of cat-rescuing firefighters. In Raleigh, he learns how to prevent the cat owner's worse nightmare: cat spray! Lastly, John ventures to the Sunshine State to visit Key West, home of Hemingway's famous polydactyl cats.

An exploration of the cat culture in Japan features the Maneki Neko, or "Beckoning Cat"; cat cafés; custom designs for homes; Tama, the train-station master; Tashirojima, aka Cat Island; and a shelter for rescued cats, including ones left behind after the 2011 earthquake and tsunami.

Florida golfers help cats that live around the course; a Baltimore cat show features house cats and purebreds alike.

Must Love Cats goes to England! Cheshire Cats, famous pub kitties, the world's loudest cat, and a pet that somehow traveled hundreds of miles from home. While there, John meets the kitty that holds the Guinness record for the loudest cat purr.

A trip to New York's Hamptons to meet a personal chef for cats. Also: a fashion designer for cats in New Jersey; a cat that needed a kidney transplant.

An Oregon woman who taught her cats how to swim; a San Francisco woman who designs jewelry using her cat's fur; a visit to a cat hotel in Los Angeles.

A kindergarten for kittens; software applications for cats; how cats survive falls from considerable heights; cats that help prison inmates.

John Fulton is on the prowl to find the coolest cats on the west coast.