Zach interviews talk show host Jimmy Kimmel.

Sean Penn sits down with Zach's twin brother, Seth Galifianakis.

President Barack Obama sits down with Zach Galifianakis for his most memorable interview yet.

Zach sits down with Bruce Willis; one of the stars of the new movie Red, to talk about the 80s and some of the prestigious awards he has been awarded.

Zach sits down with Tila Tequila who may become his new best friend and also welcomes another guest on the show who some people may recognize (Jennifer Aniston).

Zach Galifianakis sits down with James Franco to have a normal, everyday, run of the mill interview.

Zach puts Michael Cera, the Superbad and Juno star in the hot seat for this special Comedy Death-Ray interview.

Zach sits down with the host of the Tonight Show, Conan O'Brien, and his announcer, Andy Richter.

Zach sits down with Ben Stiller, star of the 'Meet the Fockers' series as well as the new movie, Greenberg.

Zach interviews Jon Hamm of AMC's Mad Men.

Zach Galifianakis sits down with Justin Bieber for an interview no one will ever forget.

Zach sits down with Will Ferrell, the star of Everything Must Go, Anchorman and Old School, to talk about lunch, dance teams and to show a never before seen clip from his movie.

Jerry Seinfeld and Cardi B sit down with Zach Galifianakis for an interview without coffee, cars, or money moves.

Zach interviews Natalie Portman and her dog, Whiz.

Zach chats with Bradley Cooper, star of "The Hangover."

Zach Galifianakis sits down with Jennifer Lawrence, Anne Hathaway, Christoph Waltz, Naomi Watts & Amy Adams who are getting all the buzz during this Oscar season.

Zach has a chat with Charlize Theron, Academy Award winner and star of The Road.

Zach Galifianakis sits down with Bradley Cooper, Jessica Chastain, Sally Field and another special guest from Lincoln.

Brad Pitt sits down with Zach Galifianakis for his second most memorable interview yet.

Hillary Clinton sits down with Zach Galifianakis for her most memorable interview yet.

Zach sits down with Steve Carell from "The Office" and they quite possibly discuss "Dinner for Schmucks".