Cesare leads an investigative commission into Juan's death, but cannot find the guilty party and soon fears he himself killed his brother.

Rodrigo has his back on the wall as the French troops occupy the Eternal city, but thanks to his son Cesare, a fragile peace can be negotiated.

Cesare's ultimate judgment is realized while Lucrezia struggles to make sense of her family's history and its future.

To prove himself worthy of the crown of Naples, Juan proposes to convert the Jews in a mass christening, but accidentally reveals a dark secret.

Cesare covets the hand of Carlotta d'Aragona and the Naples throne. Rodrigo et Lucrezia, for their part, wold like to turn the page on the death of Juan Borgia.

Savonarola was sentenced to death by hanging by the Pope Alexander VI after admitting acts of heresy under torture. He uses his last breath to curse Cesare Borgia and the whole family, in the name of God. Later, Cesare attend Midnight Mass and Easter lights the traditional fireworks fireworks Florentine. Alessandro, his lifelong friend, wish him "peace of God", but the peace of God is more interested Cesare.

Alessandro Farnese, treasurer of the Vatican, announces that the signorie of Imola and Forli haven't paid their taxes. The pontiff then summons Caterina Sforza, the Regent, and her son, the heir of these principalities. Furious for being forced to pay high taxes, Caterina arranges a plan to assassinate the Pope. Meanwhile Cesare, at the head of an army of three hundred soldiers, manages to seize the duchy of Milan.

Rodrigo promises estates and offices for those voting in his favour, and when white smoke rises, he leaves the conclave as Pope Alexander VI.

By the intervention of Spain, France is forced to withdraw, but Isabella of Spain demands a purge of the Jews from the Eternal City.

While Lucrezia is head of the Vatican, Rodrigo Borgia continued his retreat. He tries to erase his feelings of love for Julia and her desire for her own daughter, now married to Alfonso di Calabria. But even away from all temptations, he struggles to get there. For his part, his daughter, a young woman who became regent seat with wisdom and moderation, qualities that are lacking in Cesare. The latter, still at war in Romagna, hopes to achieve with a little luck to defeat Catarina and all the enemies of the Borgia family ...

Lucrezia is in a delicate position with the return of Rodrigo Borgia. It reigns supreme and does not hesitate to be cruel to his enemies. Pope became a counselor with him, Lucrezia can neither impose his word, nor to stop the fears of her husband, which occurred with the arrival of Cesare in Rome. The son Borgia is carried by his desire for conquest. Fierce, he is ready for anything ...

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.

When a plot to poison the pope is baffled and the pontiff's original testament restored, Cesare watches his brother rise further in Rodrigo's esteem.

The wedding of Lucrezia to Giovanni Sforza is to seal the union between the Borgia and Sforza families, but the marriage will not be consummated.

As peace remains brittle, Rodrigo publicly acknowledges his paternity of Juan, Cesare, Lucrezia and Goffredo to strengthen the family bonds.

Instead of keeping the peace, Rodrigo gives in to Giulia's urging and has his men take up arms, but under Juan's command the campaign fails.

In the vineyards of the Palazzo dei Santi Apostoli, Cardinal Giuliano della Rovere selects grapes for the blessing of first fruits. He is assisted by Cardinal Raffaele Riario Sansoni, more concerned with political cases. Released from his vows of Cardinal Cesare is of golden armor that belonged to his late brother Juan. Thus dressed, he poses as a king on the papal throne, having finally materialized all its own idea of "ascension" to heaven.

A quarrel starts among the cardinals and old reckonings are being settled, while Cesare offers his son as a sacrifice to God, abandoning the newborn.

With his enemies advancing and his troops deserting Juan's command, Rodrigo has to take a tough decision that puts Cesare's life at stake.

Cesare Borgia celebrates Mass on Ash Wednesday for the King of Naples and his court. According to the liturgical texts, Cesare made ​​a sign of the cross on the forehead of each participant with ash, in these words: "Remember that you are dust and to dust you shall return." But when comes the turn of King Federico d'Aragona, Cesare draws a "C" on his forehead. Thus causing the sovereign Cesare stands in contradiction with the spirit of contrition associated with this holiday.

Sent by Pope Alexander VI, Cesare and Alessandro are entering in Florence. Unlike Jesus, they are not greeted by hosannas and palm leaves, but by the looks of reproach and disapproving murmurs. Under the control of Savonarola, Florence Florence libertine became austere. Later, Cesare attends Mass on Palm Sunday, celebrated by Savonarola. During the ceremony, Nicolas Machiavelli discusses Cesare hoping to join the clandestine opposition to Savonarola. Ironically, Machiavelli tends to Cesare a sling, made with palm leaves tied in a bow shape.

Cesare's new mistress could trigger a diplomatic incident, and public allegations of debauchery are made against the Borgia family.

When one of his commanders captures a city without authorisation, Cesare must appease a ruler. Lucrezia's son suffers a potentially mortal fall.

While Rodrigo engages in delicate politics, Leonardo da Vinci offers Cesare a powerful weapon and murder visits the Borgia family.