The wedding of Lucrezia to Giovanni Sforza is to seal the union between the Borgia and Sforza families, but the marriage will not be consummated.

Rodrigo has his back on the wall as the French troops occupy the Eternal city, but thanks to his son Cesare, a fragile peace can be negotiated.

Cesare leads an investigative commission into Juan's death, but cannot find the guilty party and soon fears he himself killed his brother.

Sent by Pope Alexander VI, Cesare and Alessandro are entering in Florence. Unlike Jesus, they are not greeted by hosannas and palm leaves, but by the looks of reproach and disapproving murmurs. Under the control of Savonarola, Florence Florence libertine became austere. Later, Cesare attends Mass on Palm Sunday, celebrated by Savonarola. During the ceremony, Nicolas Machiavelli discusses Cesare hoping to join the clandestine opposition to Savonarola. Ironically, Machiavelli tends to Cesare a sling, made with palm leaves tied in a bow shape.

On the occasion of this celebration, Cardinal Riario Sansoni organizes morality recounting the story of Alexis. Far from these concerns, Cesare continuing negotiations to try to raise an army and get a title and a wife. Conversely, Lanzol asks to leave Rome and intrigues in order to devote himself more confidently to Christ.

The episode is marked by Sorrows hitting the Borgia family. Kneeling before the tomb of Juan Vannozza pray the Rosary of the Seven Sorrows aloud. Lucrezia interrupts to ask about new secrets about their family she has heard. Vannozza refuses to answer but encouraged to meditate on Fifth pain. During his prayer, Lucrezia begins to understand the secret history of his family and is considering how to fix past mistakes.

Alessandro Farnese, treasurer of the Vatican, announces that the signorie of Imola and Forli haven't paid their taxes. The pontiff then summons Caterina Sforza, the Regent, and her son, the heir of these principalities. Furious for being forced to pay high taxes, Caterina arranges a plan to assassinate the Pope. Meanwhile Cesare, at the head of an army of three hundred soldiers, manages to seize the duchy of Milan.

While Rodrigo engages in delicate politics, Leonardo da Vinci offers Cesare a powerful weapon and murder visits the Borgia family.

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.

With a new pope crowned and order breaking down, Cesare finds himself with more and stronger enemies than ever.

Cesare stands trial for treason against the Holy See and the Ten Commandments, with his old friend Niccolo Machiavelli as prosecutor.

Cesare is brought to La Mancha and goes on trial before the Inquisition, while Lucrezia must use extreme measures to save her marriage.

Though officially their uncle, Cardinal Rodrigo Borgia gathers his three children, but Juan's and Cesare's lack of control threaten his life's work.

When a plot to poison the pope is baffled and the pontiff's original testament restored, Cesare watches his brother rise further in Rodrigo's esteem.

A quarrel starts among the cardinals and old reckonings are being settled, while Cesare offers his son as a sacrifice to God, abandoning the newborn.

Rodrigo promises estates and offices for those voting in his favour, and when white smoke rises, he leaves the conclave as Pope Alexander VI.

As peace remains brittle, Rodrigo publicly acknowledges his paternity of Juan, Cesare, Lucrezia and Goffredo to strengthen the family bonds.

Instead of keeping the peace, Rodrigo gives in to Giulia's urging and has his men take up arms, but under Juan's command the campaign fails.

With his enemies advancing and his troops deserting Juan's command, Rodrigo has to take a tough decision that puts Cesare's life at stake.

By the intervention of Spain, France is forced to withdraw, but Isabella of Spain demands a purge of the Jews from the Eternal City.

To prove himself worthy of the crown of Naples, Juan proposes to convert the Jews in a mass christening, but accidentally reveals a dark secret.

Savonarola was sentenced to death by hanging by the Pope Alexander VI after admitting acts of heresy under torture. He uses his last breath to curse Cesare Borgia and the whole family, in the name of God. Later, Cesare attend Midnight Mass and Easter lights the traditional fireworks fireworks Florentine. Alessandro, his lifelong friend, wish him "peace of God", but the peace of God is more interested Cesare.

In the vineyards of the Palazzo dei Santi Apostoli, Cardinal Giuliano della Rovere selects grapes for the blessing of first fruits. He is assisted by Cardinal Raffaele Riario Sansoni, more concerned with political cases. Released from his vows of Cardinal Cesare is of golden armor that belonged to his late brother Juan. Thus dressed, he poses as a king on the papal throne, having finally materialized all its own idea of "ascension" to heaven.

A violent rainstorm fell on Rome. Rodrigo Borgia, Pope Alexander VI, is doing sex with his mistress, Giulia Farnese, when the ceiling of the papal chamber collapses on them. Rodrigo found alive under the debris, is in shock. Like the apostles, he began to speak in different languages​​, believing that the Holy Spirit is in him.