James and Martin pick up ingredients from local establishments in the Durham, N.C., area, then concoct a high-calorie beer with the help of Fullsteam's Sean Lilly Wilson.

James and Martin visit Revolution Brewing in Chicago, where they team up with the craft brewery's managing partner Josh Deth to create the "greenest" beer ever for Saint Patrick's Day.

Anthony Gibson of the Tenaya Creek Brewery in Las Vegas helps James and Martin craft the world's most expensive beer.

Sam Calagione from the Dogfish Head Brewery helps James and Martin attempt to create a brand new beer while racing in the back of a truck at Dover Speedway.

Ska Brewing co-founder Dave Thibodeau works with James and Martin to craft an "ancient beer" that hasn't been made in centuries.

In an RV in Northern California, James and Martin make impromptu craft pairings with campfire food and create the ultimate collaboration beer with the help of a local professor, known as the "Pope of Foam."

James and Martin visit Hawaii and create a sugarcane and coconut flavored "Hot Lava Rock" beer, based on the lifestyle and history of Maui.

Andy Klein of the Alaskan Brewing Co. helps the guys concoct a survivalist beer; James and Martin create their beverage in an ice cave, using glacier water and spruce tips as ingredients.

James and martin create a revival beer in New Orleans; building a mobile brewery on the back of a fan boat.

James and Martin captain two teams of Los Angeles home brewers in a competition to create the best new boundary-pushing beer.

James and Martin brew the world’s most-caffeinated beer -- a big, bold, chocolate-coffee imperial stout -- on the top deck of the Bainbridge Island Ferry.

Along with Sam Adams’ proprietor and legendary craft beer entrepreneur Jim Koch, Martin and James brew a Boston Clambake beer, infused with lobsters and clams and brewed on a tall ship sailing through Boston Harbor.

James and Martin set out to make a quintessential Southern California brew by using ingredients they harvest themselves, including kelp and the world’s hottest chili -- brewed while traveling 70mph on a train up the Pacific coast.

James and Martin make The Most American Beer Ever Brewed. It’s brewed on a float during a Fourth of July parade -- and the final ingredient is added as fireworks light up the Philadelphia sky.

The guys brew the ultimate Western beer -- a solar-powered, cactus-infused, meat pale ale -- at 14,000 feet, using only the sun’s rays to boil the brew.

The Brew Dogs get “foggy” in San Fran by making the world’s first vaporized beer. You don’t drink this beer, you inhale it!

The BREW DOGS create a uniquely Oregonian beer -- a fresh-hopped, blackberry-infused Berlinerweisse -- while floating on a beer-keg raft down the Willamette River.