Castile's new King sets foot on his kingdom for the first time and he is not welcomed. He declared himself king when the titular Queen, his mother Joanna The Mad, still lives. And he intends to rule without speaking a word of Castilian.

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Charles is finally crowned Emperor by the Pope, but joy is quickly followed by tragedies.

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The King knows his Flemish advisers only look for their personal interests. Feeling lonely, he finds solace in Germaine's arms.

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Both Charles and Francis are getting to the end of their lives.

Spain and France meet in the battlefield, resulting in an unexpected prisoner of war.

Maximilian's death leaves the Empire throne vacant. Francis I and Henry VIII want it, but Margaret of Austria will be Charles' best ally in the race.

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Tired of ruling, Charles arranges the distribution of his many kingdoms among his heirs.

While Charles is away in Europe, Commoners rise in arms in Castile.

Charles is the new emperor, but his fight with Francis I is not over. Meanwhile Hernan Cortez and Moctezuma meet.

Europe unites against the emperor. Meanwhile, Isabella is determined to prove herself more than a mere queen consort.

It's been years since Isabella's death. While Charles is away from Spain, going from battle to battle, Philip is already a grown man.

Charles V lives his last days in a monastery, sad and tired, accompanied by Francis Borgia. But life will still provide him with one last joy.