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Margaret Cho leaves behind her laid-back, no-rules lifestyle with her friends and swaps places with Holly Robinson-Peete, a married mother of four who beliefs in staying organized and keeping a tight schedule.

Cloris Leachman is an Academy Award and nine-time Emmy Award winning actress who lives in the quaint and quiet community of Topanga Canyon, CA with her daughter Dinah, Dinah's husband Tom and their daughter Hallelujah. Pia Zadora is a Golden Globe Award-winning actress and singer who lives in Las Vegas, NV with her husband Michael and son from a previous marriage, Jordan. When it's time for the swap, Cloris and Pia arrive at their new homes and are immediately not happy.

The wives of Sean Lowe and Jason Mesnick, former cast members on "The Bachelor," swap places. Sean's wife leaves behind her life as a full-time homemaker in Dallas and heads to Seattle, where she takes on Jason's wife's job as a morning radio-show host.

Reality-TV star Angela "Big Ang" Raiola trades lives with actress Alana Stewart, who shares a home with her ex-husband, George Hamilton.

Actor Tommy Davidson's fiancee Amanda trades lives with actor Corey Feldman's fruitarian girlfriend, Courtney.

When actress Kellie Williams trades lives with singer CeCe Peniston for a week, the two gain perspective on each other's lives.

Actor Robert Carradine leaves his reclusive private island to trade places with former professional football player Terrell "T.O." Owens.