Cesar Millan and his son, Andre, road trip to St. Louis, Missouri to help an organization with a dog that was recently rescued from a puppy mill and shows signs of anxiety around people. Missouri is considered the capital of the puppy mills of the United States, so this story is sadly a common one. The Millans take this opportunity to meet with some local heroes who have been fighting puppy mill abuse.

Cesar and Andre Millan visit Washington, D.C., where Rep. James McGovern and Elliot Russman, CEO of Fidelco Guide Dogs Foundation, are working to provide blind veterans with free guide dogs. The Millans introduce a guide dog to a blinded war veteran for the first time. Then they visit Jay Kohne, an army veteran suffering from posttraumatic stress disorder who is having issues with his service dog.

Cesar and Andre Millan crisscross the United States to work with nonprofit organizations and dog lovers that are helping save millions of canines around the country. Their first stop is in Los Angeles, where they help an amazing golden retriever named Fergus who survived a horrific burning. Fergus' owners hope that he can become a therapy dog for other burn survivors, but they need Cesar's help.

Cesar and Andre Millan journey down the West Coast to visit with heroes of the canine communities of San Diego. After Cesar's live demonstration in downtown San Diego, where hundreds of fans brought their dogs to get real-time take-home tips, Cesar takes Andre to Tijuana, Mexico, to visit with Dog Rescue Without Borders, an organization that works to help lessen the city’s massive stray dog population.

Cesar Millan and Andre travel to San Francisco to help locals with their dogs. The first stop is Cesar's live event, where hundreds of fans have brought their dogs to get real-time take-home tips from the experts. Then, the Millans meet Pali, the founder and president of Rocket Dog Rescue, who canvasses local San Francisco shelters trying to find homes for dogs on the euthanasia list.

Cesar and Andre Millan head to Chicago to meet some local heroes doing great work for man's best friend. First up is Michelle Kong, who oversees an online volunteer organization called the Unofficial Rescue Team, which uses Facebook alerts to respond to sightings of strays. Next, the Millans meet Rosemary Hurley, who has spent 10 years creating a dog-friendly area in her neighborhood.

Cesar and Andre Millan head back to Los Angeles, where they perform a public demonstration of take-home tips for local dog owners at their first-ever evening show, in Rancho Santa Margarita. Next, they visit two dogs rescued from the foreign dog meat trade. First up is Luke, a 1-year-old Australian shepherd mix who growls at everyone. Then the Millans meet Brutus, who has aggression issues.

Cesar Millan and his son Andre visit Philadelphia, where they work with a nonprofit that rescues dogs and trains them for the police force. The duo helps her rehabilitate a biting Belgian Malinois named Sting. The dog has huge potential, but his bad habits are holding him back from becoming a police dog.