Based on a teleplay from the original "Charlie's Angels" series, the girls must break out of jail in their quest to crack a case. This time, they pose as unsuspecting American tourists to crack a kidnapping ring in Cuba. Upon arrival at the hotel, they are framed and thrown into a women's prison, where their key victim, Tess, is also incarcerated. Bosley joins forces with his ex-girlfriend, CIA operative Samantha Masters, but is this partnership something more?

After a tragic incident, Abby and Kate meet their new partner, Eve, a street racer who has a mysterious past.

The Angels infiltrate the fashion world to investigate a model's disappearance; Kate's ex is involved with the case.

The Angels take the case of an investigative journalist who disappears on a cruise ship, a case that connects with Kate's past.

The Angels are dispatched to rescue a family from a ruthless group of kidnappers. While on the mission, they discover the kidnapping is part of a larger plan targeting a Wall Street titan's wife and her son. Charlie suspects that Abby's father has a connection to the case and urges her to reconnect with him, even though it's been five years. Abby reluctantly agrees, knowing that she will have to address some old feelings that will resurface when she sees her father, Victor Sampson

Bosley's identity has been compromised, and he has been unjustly tied to a kidnapping that the Angels are investigating. In order to clear him, they must find the real perpetrator.

The Angels must uncover who is behind the assassination of an African king while protecting his son, Mark, the sole heir to the throne. As Mark struggles to deal with the tremendous responsibility that is suddenly thrust upon him, Ray works alongside Kate to investigate the shooting, which causes her to reconsider their relationship.