Ellie Pratt and April have a long-standing history of rivalry, despite being friends in college. Ready to put this behind her, April is delighted to spend time with Ellie during her visit to Boston - that is, until she discovers why Ellie is there to begin with. Meanwhile, Beth is faced with troubling news that threatens her career and relationship.

Whether it's the Italian honeymoon that never happened, the unchecked item on her bucket list, or her lack of inspiration, all signs point April to Rome. Caught up in the midst of family drama, April faces too many distractions that keep her from making progress on her book. But will April find the inspiration she seeks in Rome, or will this trip lead her down another path? Meanwhile, Brenna receives devastating news from Finn.

April and Leo are in the throes of wedding planning and coming at crossroads when Sara suggests they take a newlywed quiz to help them learn more about each other. Meanwhile, Sara and Beth try to take a night off from dating drama as Brenna finds herself in a big mess with Margo’s crazy ex.

As the wedding date draws near, April is forced to face a list of “lasts,” such as her last week of living at home and her last time being a single girl. While her natural instincts are to have a classy and low-key bachelorette party, Vanessa helps April realize that this might be her last time to live it up. Another possible “last” opportunity presents itself for April when Dominic sets up a meeting for April with his book agent. With her health still in question, this opportunity may be April’s first (and last) chance to get a book published.

April and Leo try their hand at married life, but April worries that Leo has started planning for a future she may not get.

Newly engaged and unemployed, April tries to come to terms with her new reality. Always one to think two steps ahead, she decides to no longer plan for her future but just enjoy the moment she is in with a little help from fellow cancer patient Vanessa. First up is to plan and enjoy her engagement party!

April has a weekend getaway with Beth in Bermuda, but it's not the carefree trip they envisioned. Elsewhere, Sara faces some financial troubles; and Brenna finds a sense of belonging at Charton.

Standing in April's shadow, Brenna stifles her true feelings as she leaves Charton and turns to Natalie for support. Dominic attempts to rebuild a relationship with his mom. April goes wedding-dress shopping.

It is the day they have all been waiting for – April and Leo’s wedding day.

After a shocking traumatic event, April is left reeling and is flung into a world of grief.

April uses her new financial security to do anything and everything she can do feel good again.

April uses her reporter skills to discover a family secret.

Eager to get her book published, April meets with a literary agent who gives her advice she is reluctant to accept. It’s not until she meets a young friend at Camp Hendrie, who helps put things in perspective. But April is not the only one who will need a different point of view. Meanwhile, Brenna opens up about her feelings regarding her father.

April tries to impress her boss and gets involved in an office romance. She then receives a unexpected diagnosis, when she finds out she has cancer.

April gets a new assignment at work and reports to a new supervisor, Raquel. Sarah urges Brenna to get an after-school job to learn more about responsibility.

April is forced to defend herself when her controversial article becomes national news; Beth recruits Brenna and Greer for a fashion show; Sara suspects that Emma is hiding something.

April and Dominic share family secrets with one another when they visit a psychic. George has a official diagnosis for April, whilst Sara feels she is been ignored.

April goes on a joyride with Leo before starting her treatment, and manages to gain insight into his recklessness and the severity of his illness.

April tries to make a new start with Leo; Dominic and April spend an awkward evening together covering the same news event; George and Natalie share unexpected news with the Carvers.

When Beth hosts a house party, April lets loose – a little too loose – which leads to a major blowout with her friend. The new school year finds Brenna feeling alone and bullied. Meanwhile, Leo gets some valuable advice from Sara and ends up getting a job, but he finds the new experience more challenging than he expected.

April finds the going tough as she attempts to balance everything, including her first bone-marrow biopsy. Leo comes to an assumption about April's motives.

April goes to see a fertility doctor before beginning chemotherapy and also seeks advice from her support group about how to reveal her illness to Dominic.

April returns to work and learns there have been major changes at the paper during her absence.

The Carvers are thrilled to learn Natalie is a match for April, until Natalie has second thoughts. April has to re-earn her boss’s trust. Meanwhile, Brenna spends a surprising night out with Natalie, and Beth’s relationship with Graham puts her in an awkward position with Dominic.

April panics about a recent recurrence of her cancer symptoms and her worries increase about the stability of her remission. A desperate search for ways to alleviate her anxiety leads her down unexpected paths. The tension between April and Leo is still palpable, but a twist of fate may encourage them to reconnect. Meanwhile, Sara hosts a college prep meeting for other parents and students from Brenna’s school, and Brenna becomes increasingly annoyed by the pressure of Sara's expectations and worries for her academic future. Beth’s job is taking up all of her time, which has repercussions in her personal life.