Comedian Josh Wolf, comedian Margaret Cho and TV personality Ross Mathews

Comedian Jo Koy, comedian Natasha Leggero and comedian John Caparulo

The incomparable Kevin Spacey is here to talk about his new film Casino Jack. Comedian Chris Franjola, comedian Whitney Cummings and E!'s own Michael Yo.

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From One Tree Hill, Sophia Bush is here and were going to find out if she wants to be anything other than what she's been trying to be lately. Comedian Brad Wollack, actress-comedian Arden Myrin and comedian Dov Davidoff

One of our favorite people ever Zach Gilford is here to tell us about his new show Off the Map. Comedian Jo Koy, comedian Sarah Colonna and comedian Jason Sklar

The unmatched Roseanne Barr is here with her new book Roseannearchy. Comedian Josh Wolf, comedian Matt Braunger and TV personality Ross Mathews

Sara Bareilles and her chart topping album Kaleidoscope Heart are on the show tonight. Comedian Bobby Lee, comedian Loni Love and comedian T.J. Miller

Find out what Denis Leary has going on, hint: a new comedy special, a new book and the new Spider-Man movie. Comedian Josh Wolf, comedian Natasha Leggero and comedian Jason Sklar.

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The newly engaged Ginnifer Goodwin from HBO's Big Love joins us tonight. Comedian Greg Proops, comedian Whitney Cummings, and TV personality Ross Mathews

Matt LeBlanc is here to tell us about the very funny new Showtime series he stars in, Episodes. Comedian Chris Franjola, writer Diablo Cody and comedian Dan Levy

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TV host Piers Morgan on his new show, Piers Morgan Tonight; Round table discussion with comics Chris Hardwick, Rove McManus, and Jo Koy.

Actor Wilmer Valderrama on his new film, From Prada to Nada; Round table discussion with comics Gary Valentine, Ross Mathews, and Sarah Colonna.

Taraji P. Henson is back and has a lot going on including the new Lifetime movie Taken From Me: the Tiffany Rubin Story. Comedian Bobby Lee, actress-comedian Arden Myrin and comedian Ben Gleib

The headline-making director of the new film Red State, Kevin Smith is here. Comedian Brad Wollack, comedian Dov Davidoff and comedian Natasha Leggero.

Our good friend Kevin Nealon is here from the new movie Just Go With It. Comedian Joy Koy, E!'s own Michael Yo and comedian John Caparulo

Rachel Bilson is here from the new film Waiting for Forever. Comedian Bill Bellamy, comedian Whitney Cummings and comedian Chris Franjola

The staff plays in a men vs. women football challenge in honor of the upcoming Superbowl. Comedian Josh Wolf, comedian Heather McDonald and comedian Lavell Crawford.

Jennifer Aniston is back to tell us about her new movie Just Go With It. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Ryan Stout

From the No. 1 movie in America The Roommate, Minka Kelly is here. Comedian Joy Koy, actress-comedian Arden Myrin and comedian Greg Proops.

James Blunt is here and he's got a new album called Some Kind of Trouble. Musician Jeff Wild, TV personality Ross Mathews and comedian Gary Valentine

From the new Fox drama The Chicago Code Jennifer Beals is here. Comedian Josh Wolf, comedian Loni Love and comedian Mo Mandel

Star of the film Justin Bieber: Never Say Never, Justin Bieber is here tonight. Comedian Jim Norton, comedian Heather McDonald and TV personality Ross Mathews