A mother is suspected in the murders of two of her daughters, when her third daughter finally convinces police to reopen two cold cases.

In the 1980s, a serial killer prowled the posh streets of Orange County. Police were unaware of the serial attacks until 1996, when DNA revealed the killer's secret and they linked four murders to a single DNA profile. Detectives uncovered three more crimes attributed to the man dubbed "The Original Night Stalker" before learning he had an earlier career as a serial rapist! Watch as cold case detectives compare the attacker's DNA with nearly every convicted violent offender in California.

The murder of an Ohio woman in 1974 is solved more than 20 years later after police get a crucial clue--the woman's husband was seen building a coffin-shaped box about the time the woman disappeared.

After the murder of her aunt goes cold, a woman helps launch Citizens Against Homicide, an advocate group that brings awareness to cases that have gone unsolved. And police solve a young girl's rape and murder when the car where her body was discovered acts like a refrigerator, preserving half of her body and allowing authorities to recover incriminating DNA from semen in her body.

A 13-year-old girl's mother is murdered and 20 years later she helps bring the killer to justice; and a dogged policeman gets to the bottom of the brutal murder of a 63-year-old newspaper delivery woman.

A woman's fall from a cliff in the Grand Canyon leads police to uncover a series of grisly murders, and investigators smoke out a killer when they find crucial DNA evidence on his cigarette butts.

A series of brutal rapes in St. Louis goes unsolved for many years until a fluke audit of a license plate number leads police to the culprit.

A boy's toy Batmobile car provides an important clue for detectives struggling to make a case against a serial killer who stalks and kills waitresses.

Fire investigator Jack Malooly helps crack the case of an arsonist and killer who set a series of fires to collect insurance money; and a prison inmate tells a homicide detective that he can't help him with his current murder investigation, but knows plenty about another murder that took place in California 15 years earlier.

Police run down more than 11,000 leads before coming up with a suspect in the murders of three Virginia girls; and the abduction and strangulation of a California woman continues to baffle investigators more than 11 years after the crime.

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In this special 100th edition of Cold Case Files, we look at the biggest serial murder case in U.S. history - the 20-year hunt for the Green River Killer. Dave Reichert, the detective who made finding the killer his obsession, walks us through the case. He tells vivid, sometimes harrowing stories about the murders, saying, "You never forget the sight of a 16-year-old body lying on her back on the riverbank with ligature around her neck." Reichert headed up two Green River task forces until forensic DNA technology helped crack the case and brought him face to face with the killer thought to be responsible for 48 deaths.

A 14-year-old boy is charged with the murder of his sister, but his public defender believes the police coerced the boy's confession and that the real killer is still on the loose. And two deteriorated medical examiner's slides, made in a murder investigation 16 years earlier, give police the evidence they need to reopen the cold case and bring the lead suspect to trial.

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A killer's bite marks and a jailhouse snitch lead to a murder conviction in a case gone cold for eight years, and Bill Kurtis joins a group of super sleuths trying to solve the slaying of 18-year-old Jamie Weiss, found dead in her bathtub in 1996.

The suspicious death of 2-year-old Billy Blankenship is solved when police force his babysitter to re-enact the circumstances of his death. Then, a murder case is solved when the dead man's body is accidentally found by divers searching underwater for an antique car.

Klan leader Sam Bowers goes on trial for ordering the murder of an African-American storeowner 32 years prior, and investigators reopen the unsolved case of an African-American truck driver who was forced to leap to his death from a bridge by Klan members.

After U.S. Navy sailor Andrew Muns disappears in 1968, the Navy claims that Muns went AWOL from his ship. But his sister works tirelessly for over 30 years to prove that Muns was really killed. And DNA surreptitiously gathered from a cigarette butt helps detectives to unravel a 20-year-old case of rape and murder.

Investigators in Virginia, probing the murder case of a sailor, seek the help of a forensic anthropologist from the "body farm" in the Great Smoky Mountains. Dr. William Bass became an expert on the human body's rate of decay by watching bodies rot at his plot at the University of Tennessee and keeping tables of weather data.

A killer helps convict himself when he boasts about his crime to prison cellmates; and New Hampshire investigators probing the murder of a pregnant woman found raped, strangled, and dumped into her bathtub, get a new lead when they discover a similar case in Florida.

After a long manhunt, cops finally close in on a serial killer with the help of the Internet and information supplied by a subsidiary of Microsoft. And a drug trafficker jumps bail, goes into the bike shop business, and helps pioneer the sport of mountain biking while he's on the lam.

Our cameras follow Detective Manny Reyes as he investigates the 1990 murder of a Fort Worth, Texas woman. Reyes talks to the woman's two sons, who believe that her husband, Bobby, was the murderer. We then watch as one of the husband's relatives tells Reyes that Bobby has confessed the crime to him. To make the case even stronger, Reyes collects physical evidence that connects him to the crime. Finally, Reyes meets Bobby for a dramatic interrogation. Will he crack and admit the crime--or will he hang tough and deny it all?

New DNA technology and the national DNA databank help police hunt down a rapist-killer 11 years after he committed his crimes, and a detective's painstaking recreation of a woman's shooting death proves it wasn't an accident.

A murderer's saliva, found on envelopes that he sealed, helps seal his doom 37 years after his first killing. And Colorado police crack a cold case 24 years later when they take a DNA sample from the victim's son that proves that his father murdered his mother.

The killing of a woman in a Virginia hotel room goes unsolved for a quarter of a century before investigators are finally able to zero in on the likely killer. And, when a 25-year -old women is shot to death during a jewelry store robbery in 1980, investigators collect fingerprints and blood from the crime scene. There are few leads and the case goes cold until 1999, when detectives test the blood evidence and develop a DNA profile. For two years more, that profile sits without a match, until 2001 when a convicted burglar is entered into the DNA databank.