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Documentary•Crime

The Best Episodes of Cold Case: The Tylenol Murders

Every episode of Cold Case: The Tylenol Murders ranked from best to worst. Let's dive into the Best Episodes of Cold Case: The Tylenol Murders!

Binge this in 1h 59m•Peaking at 7.2/10

Who really laced Tylenol with cyanide? This true-crime series examines alarming theories behind the unsolved killings — and tracks down a key suspect.

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Episode Rankings

  1. #1 Fan Favorite
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    Cold Case: The Tylenol Murders Season 1 Episode 1 - Pain Killer
    7.2/10(195 votes)

    #1 - Pain Killer

    S1:E1

    After cyanide-laced Tylenol kills multiple people across Chicago, police and the media scramble to spread a nationwide warning.

    Directors:Yotam Guendelman, Ari Pines
    Writer:Unknown

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  2. Cold Case: The Tylenol Murders Season 1 Episode 2 - The Bitter Pill
    7.1/10(174 votes)

    #2 - The Bitter Pill

    S1:E2

    A key suspect maintains his innocence, even as authorities discover his suspicious past and possible motive. Tylenol unveils new triple-seal packaging.

    Directors:Yotam Guendelman, Ari Pines
    Writer:Unknown

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  3. Cold Case: The Tylenol Murders Season 1 Episode 3 - Sealed for Your Protection
    6.9/10(167 votes)

    #3 - Sealed for Your Protection

    S1:E3

    Decades after the murders, a victim's daughter searches for justice — and uncovers forgotten evidence that supports a controversial theory.

    Directors:Yotam Guendelman, Ari Pines
    Writer:Unknown

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Best Episodes Summary

"Pain Killer" is the best rated episode of "Cold Case: The Tylenol Murders". It scored 7.2/10 based on 195 votes. Directed by Yotam Guendelman, Ari Pines and written by Unknown, it aired on 5/26/2025. This episode scored 0.1 points higher than the second highest rated, "The Bitter Pill".