On the move, evading retaliation, Detective Kevin Corcoran works to remain hidden while seeing through events he set in motion. Old loyalties are tested and unlikely friends are made as the people of Five Points and uptown struggle to maintain their foothold in a city driven by vengeance. A catastrophic national event shatters the hope of smooth post-war recovery for not only the people of New York City, but also the United States at large.

Looming devastation to Five Points forces Detective Kevin Corcoran to take drastic, irrevocable action. Injuries old and new push Doctor Matthew Freeman to the breaking point. As Elizabeth Morehouse spirals further into addiction, intervention comes from the unlikeliest of sources.

The Sixth Precinct's search for the killer of a fellow officer is derailed as Annie Reilly creates a rift in the Corcoran home. Madame Heissen discovers an unlikely ally. Elizabeth Morehouse soothes her conscience by aiding the Freemans. Francis Maguire finds himself crossing paths with old friends.

The greater COPPER family – Uptown and Five Points alike – gather around Detective Kevin Corcoran, who is reeling from a shocking loss. In a quest to cure the illness sweeping Five Points on a grander scale, Doctor Matthew Freeman steps beyond his role as physician. Robert Morehouse finds himself fighting to ensure that a tumultuous chapter of his past is dead and buried, and that he and his loved ones lives will continue to thrive.

In his investigation, Detective Kevin Corcoran finds himself at an unusual dead end. Doctor Matthew Freeman is faced with the outbreak of a new and troubling illness sweeping Five Points. While Elizabeth tries to help with the Morehouse business, General Brendan Donovan enlists Madame Eva Heissen to gain leverage within his own affairs.

As Corcoran closes in on the Five Points murderers, his loyalties are tested. Francis Maguire embraces his new underworld position. Robert Morehouse and Elizabeth Haverford exchange vows.

Five Points falls into a state of panic as a community safe haven is seized by one of the deadliest men in New York City. With both coppers and civilians at the mercy of a brilliant but unstable force, Detectives Kevin Corcoran and Andrew O'Brien, with Doctor Matthew Freeman and several coppers, race against time to restore peace to the Sixth Ward. As the coppers defend their home against an unrelenting foe, Francis Maguire sees an opportunity to settle a score with Corcoran.

Returning to the Precinct, Detective Kevin Corcoran is staggered when he discovers a new investigation has one close to him in chains. Racing to free his friend, Corcoran seeks help from those in power. However, General Brendan Donovan is consumed by an upcoming, major political and business move. Meanwhile, Doctor Matthew Freeman approaches Robert Morehouse to suggest a joint effort to aid the city.

A murder demands Detective Kevin Corcoran work closely with an unlikely partner as General Brendan Donovan is eager to close the case cleanly. Meanwhile, Robert Morehouse makes a difficult decision regarding the trial of Kennedy, leading to a surprising change in the proceedings. With spring on the horizon, the Freemans welcome a loved one back into their arms and home; while Madame Eva Heissen and Ellen Corcoran discover shared secrets they both wrestle to keep hidden.

February 5, 1865. Five Points remains a bedlam. Young men are dying and disappearing at an alarming rate and a career criminal is terrorizing the Sixth Ward. With pressures from Tammany Hall raining down upon the police force, Detective Kevin Corcoran and the coppers of the Sixth Ward must follow the guidance of returned ward leader, General Brendan Donovan. Meanwhile, Doctor Matthew Freeman visits his mentor and is presented with an attractive offer that will cause a rift in his marriage. Uptown, Robert Morehouse and Elizabeth Haverford make plans for their wedding and Confederate spy Kennedy’s execution. In the tombs, Francis Maguire is set to learn his fate.

Detective Kevin Corcoran begins to question the motives behind strongholds of the Five Points community, and he solicits coppers of the Sixth Precinct to suss out the truth. In a collision of public and private spheres, Robert Morehouse’s marriage creates strife in his business ventures. The Freeman family struggles to maintain their freedom and well-being while confronting bigots in their community.

As more corpses of young men are found and others continue to disappear, Corcoran leaves no stone unturned in his search for answers. General Brendan Donovan employs unseemly tactics to keep the murders out of the press. Meanwhile, as Sara readies herself to attend a dinner with Frederick Douglass at the Morehouse mansion, Doctor Matthew Freeman makes a drastic decision for the health of his community – forcing her to confront her past. With his fate decided, Maguire must fend for himself and realign his allegiances.

In the wake of national tragedy, Detective Kevin Corcoran reels like the rest of the country. As Corcoran mourns with Robert Morehouse and Doctor Matthew Freeman, the three men decide to join a national effort once more. For the three friends, the mission elicits memories from the battlefield, resurfaces faces from the past, and creates opportunity for Five Points chaos to continue unabated.