When an American man attending a festival in Mumbai wakes up missing a kidney and his friend gone, the International Response Team’s investigation leads them to suspect the UnSub is more than just trading organs on the Black Market.

The International Response Team heads to Belize to search for a couple who disappears while on their honeymoon in what appears to be a targeted abduction.

When an American college student working in Johannesburg is killed and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi, a profiler he’s worked with before who has an unorthodox style of investigation.

Unit Chief Jack Garrett and his international response team are called to Tanzania when a 23-member church group disappears.

When a night of partying ends tragically for an American 18-year-old in Tijuana, the International Response Team is called to investigate.

The team travels to Japan to assist local law enforcement in investigating homicides made to look like suicides. Meanwhile, Mae encourages Clara to get out and enjoy herself.

The International Response Team heads to Paris to search for an UnSub targeting Americans who live there.

The International Response Team travels to Morocco when a retired couple from Idaho is kidnapped while visiting the country on a cruise.

When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack and his wife, Karen, prepare to send their daughter to college.

When two casualties resemble the M.O. of the most notorious killer in Italian history, the International Response Team is called to investigate.

The International Response Team travels to Russia when an American ballerina is kidnapped, and Jack tangles with an ex-KBG agent who escaped from prison.

The International Response Team head to South Korea when an American college student is found disfigured. Also, Simmons fulfills his mother’s last dying wish to find his grandmother.

The International Response Team is investigated by the FBI after a mission in Kurjikistan results in the death of a suspect.

The IRT heads to Pamplona, Spain, for the running of the bulls, where the ears of a missing American tourist are found.

Garrett and his unit travel to Thailand when three American volunteers go missing during a trek to Bangkok. Once there, former colleague Clara Seger, a cultural anthropologist, helps them rush to gather evidence leading to the UnSub before a storm threatens to wash it away,

The International Response Team investigates when two American entrepreneurs disappear while conducting business in Bangladesh.

When an American visiting Greece to get more involved in his family's business is found beaten in a rough part of Athens, the International Response Team is called to investigate.

The International Response Team is called to Taipei when it appears an American committed a crime that is similar to an unsolved case in New York.

The IRT must find the murderer of a woman in Nepal who was at a yoga camp. Monty is on the field for the first time.

When two American flight attendants go missing while in Singapore, the International Response Team is called in to investigate.

When the body of an American singer is found on a rural road in the blue mountains of Jamaica, the International Response Team is called to investigate.

When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree killers.

The International Response Team heads to Cairo when an Egyptian-American former U.S. serviceman is killed in a gas attack there and his friend goes missing.

The International Response Team investigates the apparent suicide of an American in Colombia who emptied his bank account prior to his death.

When a woman vacationing in Mexico with her family is the victim of foul play, the International Response Team investigates her husband as the prime suspect when he flees.