When the body of a young girl who was killed over 40 years ago is discovered at the bottom of Lake Mead, Max Roby promises her mother, Raquel Williams, that the CSI team will finally find justice for her daughter. Also, Greg Sanders brings his quirky humor as he returns to the crime lab.

When David Hodges goes missing, the entire CSI team searches for any piece of evidence that can help locate him, clear his name and save the reputation of the entire crime lab.

The CSI team investigates a radioactive crime scene that left a father and son dead.

The CSI team looks closely at the eccentric world of sideshows when a couple of performers are discovered burned in a pit. Also, Hodges mulls a plea deal as his criminal trial kicks off, while Max, Grissom and Sara search for evidence to exonerate him.

The CSI team investigates the death of a local antique shop owner who died from an apparent gunshot wound that is missing one important clue - the bullet. Also, Max makes an important breakthrough in the ongoing case with Ocho from the robotics factory.

When a young, non-verbal boy is found hiding in a stranger’s garage, the CSI team searches for his missing mother. Also, Max receives a strange letter with symbols in silver ink that Folsom and Allie recognize from prior crime scenes.

As the CSI team investigates the death of a man visiting Las Vegas for a health and wellness convention, a fiery explosion traps Allie Rajan in the basement of an abandoned hospital.

The CSI team investigates when a plastinated nervous system is found hanging above a local car dealership. Also, Chavez and Max search for a missing source in their ongoing investigation of the robotics factory.

After an explosion in a bio lab, the CSI team races to determine which nerve agent left one of their own unconscious, while the others explore a dangerous underground tunnel to find another CSI who got kidnapped during the blast.

When the CSIs are called to investigate human remains found in a convention center owner’s bathtub, Sara and Grissom use the case to get close to attorney Anson Wix’s star forensic expert witness, just days before David Hodges’ trial begins

A silver ink note threatening Maxine Roby's life is found at the crime lab, sending the entire CSI team to crack who is behind the notes and how they connect to other murder case.

Medical examiner Sonya's life is in jeopardy when she is exposed to a mysterious poison as the CSI team races to find the antidote and the silver ink murderer who appears to be targeting the Crime Lab. Max's ex-husband, Daniel, returns to make sure that she and their son are safe.

When a fitness guru is found dead in a gym sauna and his soon to be son-in-law is found dead from an apparent hunting accident, the CSI team investigates to see if these deaths are unrelated tragic accidents or if they're connected.

An attack on Jim Brass kicks off a twisted conspiracy targeting the Las Vegas crime lab.

Gil Grissom and Sara Sidle come to the aid of a former colleague who is implicated in tampering with evidence. Maxine and the rest of the CSI team work the murder of a couple slain on their wedding day, following the evidence to the salacious underbelly of the Las Vegas elite.

Max puts CSI on lockdown when evidence in a new murder tips Grissom and Sara to a new suspect in the crime lab. Also, Folsom and Allie investigate a series of chilling killings at a dilapidated clown-themed hotel.

A social media influencer party ends with the brutal murder of a popular guest. Chris Park's side hustle makes him uniquely qualified to lead the CSI team in their investigation.

When a mechanic is found murdered in a dark factory, the CSI team investigates whether the perpetrator was human or a humanoid robot with an AI operating system.

Grissom and Sara's investigation into charges against David Hodges heats up as Internal Affairs joins the hunt. Also, pressure rises for the CSIs when a video game developer's body is found floating in a fountain before a huge gaming tournament.

The CSI team investigates when a body is dug up in the luau pit of a Hawaiian-themed hotel. Also, Internal Affairs begins to question Grissom and Sara's return to the crime lab.

As Grissom and Sara close in on who framed Hodges, the CSI team investigates a lock room murder mystery at 30,000 feet, when a cargo plane lands autonomously at McCarran Airport and everyone on board has been killed.

An abandoned horse covered in blood leads the CSI team to a halfway house for convicted murderers. Also, Grissom and Sara begin to circle their prime suspect in the David Hodges case.

As Halloween descends on Sin City, the CSIs investigate when a creepy mannequin prop inside a popular haunted house turns out to be a real dead body. Also, Catherine enlists the help of Folsom to search for her friend who disappeared.

Catherine’s frustration intensifies when a lead suspect in Grace’s disappearance is found murdered. The team exhausts all their skills to figure out who killed the suspect, and if his death will lead them to Grace.

When the bodies of two Regency Romantic Festival attendees are discovered, the CSI team uncovers a shocking link between their murders and previous cases.