Professor Crumhorn creates a robot duplicate of Penfold (which is far more efficient than the original). At the push of a button it transforms into a giant machine intent on destroying Danger Mouse.

Danger Mouse and Penfold are sent to the Arctic when Greenback threatens to melt the polar ice with sun lamps.

Danger Mouse is sent to stop Greenback who is behind the theft of America's greatest buildings.

Danger Mouse and Penfold are sent to track down a huge hairy monster that has been crushing the local villages. When they find it they discover he's actually friendly, but suffers from extreme bouts of sore-feet. They get help from the RCMP - Royal Canadian Mounted Podiatrists.

The Mark III runs out of gas, leaving DM and Penfold stranded in the Sahara Desert.

While on holiday in Spain, Penfold is kidnapped by a mad Coyote who thinks he is Don Quixote. They go tilting at a windmill that happens to contain Baron Greenback's latest device for world domination.