When Jen Ramsaran disappeared, police searched online for clues and wondered if she escaped the real world for a fantasy world; journalist Andrea Canning covered the case in one of her first assignments for "Dateline."

After a young Army veteran disappeared, detectives uncovered a cryptic 911 call placed 11 days before she went missing, which exposed a twisted story — and the truth; reporter Josh Mankiewicz recalls the case.

Andrea Canning recalls the twists and turns in the case of Beverly Carter, a top-selling realtor who went missing after showing a house -- when her friends received mysterious text messages, they knew something was wrong.

A case Keith Morrison can't forget in which a teen's murder shakes a Nevada community and two unlikely people confess.

When a police officer's wife is shot to death in her bed, her parents' certainty that investigators have it wrong and their determination to untangle the mystery, makes the case unforgettable for Josh Mankiewicz.

Andrea Canning recalls a case in which investigators set up an elaborate sting operation to stop a murder-for-hire plot.

A man charged with murder claims it was impossible for him to have committed the crime. For Dennis Murphy, the surprising courtroom strategy provides a memorable twist.

Keith Morrison reflects on the case of a Chicago woman from a big family who went missing. Investigators began to suspect a man in her life was full of secrets.

A detective makes it her mission to find dozens of women who vanished on the streets of Albuquerque, New Mexico. For Josh Mankiewicz, her resolve makes this story unforgettable.

After shedding hundreds of pounds, a popular kindergarten teacher goes missing. Investigators find a link between her weight loss and her disappearance. The case ranks as having one of the craziest motives Andrea Canning has heard.

This case has stayed with Dennis Murphy since he first reported on it: A determined young woman searches for answers in her mother’s mysterious death. Her decades-long quest leads to a dramatic courtroom decision.

Investigators track down a suspect in the disappearance of a celebrity dog trainer. Keith Morrison reflects on the fractured love story at the center of this mystery.

A wife calls 911 to report her husband has been shot on a country road in Texas. What she told investigators next makes this case memorable for Josh Mankiewicz.

Andrea Canning looks back on one of her most memorable cases where a fitness tracker helped detectives solve the mystery of a young woman's death in Wisconsin. Andrea confronts the killer in a tense interview.

When a star athlete at an Ivy League university goes on trial for murder, sparks fly in the courtroom. The trial ends with a stunning decision that Dennis Murphy will never forget, but the surprises in the case are just beginning.

A California woman's two former husbands are mysteriously murdered nearly 20 years apart. Keith Morrison reflects on the case that sent him halfway across the world on a hunt for answers.

When a complicated Texas love triangle ends in murder, a pink gun leads to an arrest. New evidence makes investigators rethink the case. Josh Mankiewicz has reported on two-timing before, but this case had a twist he has never seen.

When a small-town Alabama resident is murdered, rumors involving a local pastor begin to swirl. Andrea Canning reflects on this story that feels to her like a steamy soap opera playing out in real life.

Dennis Murphy reported on the twists and turns of the Jennifer Dulos case as they happened. He offers candid insight into his one-on-one interview with the prime suspect: Jennifer’s ex-husband, Fotis Dulos.

For Keith Morrison, this case stands out as an unusual mystery. The crime seemed arbitrary with no apparent motive. There was a confession which might have ended the investigation, but that was only the beginning.

A college student is found murdered and the case sits cold for nearly 40 years. Josh Mankiewicz reflects on the vow that keeps the case alive and the innovative method used to catch the killer.

An aspiring Playboy model is murdered in Miami, FL. A seven second clip of her last moments alive are caught on security video and could hold key clues. The haunting images make this case one of Dennis Murphy's most memorable.

A man claims his wife died by suicide, but a suspicious house fire 24 years later raises doubts; Josh Mankiewicz remembers the suspect who could not stop talking.

When a pastor loses a second wife in an accident, authorities become suspicious. Dennis Murphy returns to this unforgettable story of evil and betrayal, wondering how far this a man of God might have fallen. Dennis still can’t believe the answer.

Years after a Montana man is found dead, his son searches for answers. Keith Morrison cannot forget that son who opened a box, and faced a terrifying family secret.