Kidnapped just steps from her home, a 15-year-old girl is brutally assaulted and left for dead in Denver's South Platte River.

Hard-working family man Chris MacCallum disappears while on a camping trip deep in the forest along the border of California and Oregon. And when detectives start to unravel the mystery, all roads lead to an unthinkable suspect...

When the murdered body of Miami pediatric nurse Beverly Jackson is discovered under the most shocking of circumstances, her family is devastated. In the end, it takes the bravery of one young witness to finally crack the case.

When an openly gay student is brutally murdered police must investigate every lead. And some will lead where they don't wish to follow. Four young boys live in horrific conditions, will they live long enough to be free?

A troubled young mother mysteriously vanishes from her new home in Benson, Arizona where she had moved for a chance at a fresh start. Police uncover the truth of Devvra's disappearance when tips lead them through the seedy underbelly of Benson.

After he clashes with co-workers, Tom Monfils mysteriously disappears on the job at a Green Bay paper mill. Soon enough it looks like murder, but no one is talking to detectives. Is it a conspiracy of silence, or a tragic miscarriage of justice?

When 12 year-old Courtney LeBlanc is kidnapped from her home, her family fears she's fallen prey to a serial killer terrorizing the community. Local investigators enlist the help of the FBI and their search reveals a predator hiding in plain sight.

In Silicon Valley, young mother Reina Swierski is reported missing not by her husband Gary, but by her lover Ted. The search to find her goes on for years, eventually unmasking a violent and deadly predator.

In the shadow of the nation's capital, a mysterious death on a Marine base confounds the NCIS -- was it an accident, or was it a homicide? It won't be long before police are hunting a violent sexual predator whose trail leads right back to the base.

In 1995, three members of a wealthy Taiwanese family living in Virginia disappear. Rumor has it they died overseas but when detectives investigate, they find answers closer to home.

An innocent career woman is murdered on her daily walk, only a lucky tip can stop the case from closing. A California girl is kidnapped and abused, with no hope of escape, her fate rests upon the help of strangers.

Wyndi Cooper married the man of her dreams until she realizes he was an accomplished conman with other wives. And, Dino and his wife Clara do everything together. When Clara ends up dead, police try to find the culprit and end up looking close to home?

In El Cajon, California - a haven for Iraqi refugees - a young mother is brutally attacked in her home and left fighting for her life. A note left at the crime scene lead police to believe it was a hate crime. Was Shaima's Iraqi community also in danger?

All appears well in this upscale suburb of Detroit. But when a mother of two is bludgeoned to death and then stabbed repeatedly in her own garage, police and the community are shocked when the investigation leads close to home.

When beautiful fitness-fanatic Donna Zinetti is discovered brutally stabbed to death on a jogging path, detectives immediately suspect her recently-estranged husband, Keith Longtin. But not everything is as it appears.

Mother of four Becky Sue ends her relationship with her abusive boyfriend, and decides to move in with a relative for a fresh start. However, some people suspect foul play when she suddenly goes missing before testifying against her abusive boyfriend.

A talented graduate student is nursing a broken heart, when she's swept off her feet by someone new. But as their relationship progresses, revelations make it clear nothing is quite what it appears to be. [also marked as S4:E1]

A woman driving solo to visit a friend on Florida's I-95 mysteriously vanishes. Her divorce leads police one way, but when her body is found it suggests something horribly different. Another woman who reads about the case has a hunch she knows the killer.

An Alaska Teenager is found murdered and sexually assaulted. It will take a mother's love and almost two decades to find the killer. A high speed chase ensues when a girl is kidnapped, but will the police be fast enough?

Michigan Mom goes missing, her husband Doug has a strong alibi but becomes a suspect when his alibi evaporates in a twist. Young South Carolina girl is kidnapped and held captive in an underground bunker by a sexual predator.

The peace in a small town is shattered when a Muslim couple is gunned down on the street. Though badly injured, the husband survives and tells police the gunmen yelled racial slurs before firing. But was hate the only motivation for this heinous crime?

In Phoenix, a wave of late night sexual assaults appear to be the work of a serial rapist, who targets women in their own homes while they sleep.

When Jamey Walker, a young woman with a bright future is kidnapped and murdered in the spring of 1981, her mother Eleanor dedicates the rest of her life to finding the killer in hopes of finding justice for Jamey.

In St. Petersburg, FL, Cabretti Wheeler and his friend Kyle Ellis are killed.  When the only eye-witness vanishes, it's up to Cabretti's mom, Lisa Wheeler, to help police solve the case, even if it means risking her own life for justice.

When the body of a murdered young woman is found floating in the Gulf of Mexico, detectives spend years trying to identify her remains. But then a family stumbles across her description, leading to a 30 year old murder mystery that demands justice.