33-year-old Tanya Rider goes missing after her overnight shift at a grocery store in Bellevue, Wash. When her husband Tom contacts 911, emergency officials refuse to file a missing persons report because they think Rider may have left on her own. Tom must battle to get authorities to start a proper investigation, and when they finally do, detectives suspect he's involved.

16-year-old Molly Bish arrives at her lifeguard job one morning and minutes later vanishes. The disappearance has police thinking that Molly drowned, but her mother's intuition leads to an investigation of a suspicious man in a white vehicle.

Virginia Tech student Morgan Harrington promises to meet her father the morning after attending a Metallica concert, but she never shows up. Her panicked parents learn that Morgan left her friends during the concert and never came back. Witnesses paint a strange picture of her behavior outside the concert venue: she was erratic, belligerent, incoherent, and in the company of three young men. Even more bewildering are multiple reports of Harrington hitchhiking late at night on a dark road. Weeks and months go by without solid leads until forensics link Morgan’s disappearance to a violent crime in another city three hours away.

Rebellious 18-year-old Samantha Bonnell vanishes during a night out with friends. Her mother begins a harrowing search with no help from police. When Bonnell’s suitcase turns up miles from where she was last seen her mother hopes it isn't too late.

Pepita Redhair, a 27-year-old Navajo woman, goes missing after her mother drops her off at her boyfriend’s house in Albuquerque, N.M.; the family takes matters into their own hands to find her, even enlisting the help of a medicine man.

The investigation into Billy Smolinski's disappearance after he discovered his girlfriend had cheated on him. Detectives try to find out if she is behind the mystery.

Known for her quick smile and lightning speed on the soccer field, 17-year-old Brittanee Drexel from Rochester, N.Y., slipped off to spring break vacation in Myrtle Beach, S.C., without the consent or knowledge of her parents. On April 25, 2009, the night before she was supposed to come home, Drexel disappears. Video surveillance shows Drexel exiting a friend's hotel and her last known communication is a text to her boyfriend. But when police track her cell phone to an isolated rural area known for alligators and swamps, her family fears the worst.

While shopping for land in Oklahoma, Bobby and Sherilyn Jamison and their six-year-old daughter Madyson vanish. Mystified investigators uncover a series of disconnected leads pointing to drugs, family dysfunction, and even supernatural beliefs.

When Sherill Levitt, her daughter Suzie Streeter and friend Stacy McCall vanish from a house one night, the town of Springfield is left reeling. A violent criminal in the area says he knows where the women are buried, which only stirs up more questions than answers.

When an exotic bird ranch in Loxahatchee, Florida is abandoned, leaving uncertain the fate of 700 valuable birds, a bizarre mystery unfolds. The search for the missing owners, 31 year-old Moses Lall and his 36 year-old Aunt Lila begins.

The McStay family disappears from their San Diego home without a trace. There are no signs of foul play and no indication that they were running from anything. Could the McStays have intentionally walked away, or did something more sinister occur?

Jason Landry disappears while driving home for the holiday break; PI and retired FBI agent Abel Pena does his own investigation and suspects Jason may have been the victim of foul play.

Charlie Allen Jr. is excited for his future as a doctor and aspiring tennis professional. But he sends his family into a panic when he reports to his sister that people are after him. His parents try desperately to reach their son, but all attempts are futile. A few days later, police discover Allen’s backpack in a yard, his car abandoned in a campus parking lot, a link to a local break-in, and receive reports that he was seen running shirtless and shoeless along a wooded road. Police find no sign of foul play, but also no sign of Allen. As the investigation probes further, some wonder if the threat to Allen came from someplace much closer to home.

Tina McQuaig was a 27- year-old wife and mother. On the evening of March 15, 2000, after work at the hospital, she called her babysitter to say she’s stopping at the grocery store on her way home. That was the last anyone heard from McQuaig. When her car was found four days later, her keys and purse were gone, as if she parked and walked away. As authorities probe McQuaid’s life, they discovered secrets that stun her husband and family.

Nineteen-year-old Ginni Wood embarks on a 1500-mile spring break road trip from North Carolina to Texas to visit her best friend Kelly Gaskins. Wood speaks to her mother upon arrival, but then disappears along with Gaskins and her boyfriend Ervin Williams. Investigators soon realize that Ervin is wanted back in North Carolina on charges of assault and arson. The girls’ families wonder if Ervin is involved in their disappearance, or if he’s a victim himself. When police learn that the three kids may have crossed the border into Mexico, they question where to turn for answers.

On July 7, 2007, 18-year old Jarrod Johnston walks away from his grandmother's home in Mississippi. His Dad sees similarities between his own sister's disappearance 25-years earlier and his son's. It becomes hard to hold out hope his son will ever return.

26 year old Kirsten Brueggeman was last seen in Indianapolis, Indiana on January 2, 2021. At 2:00 am she was seen walking through the YMCA parking lot on North Shortridge Road. Kirsten hasn’t been seen or heard from since.

Successful lawyer and new mum Ciera Breland disappears after she and her husband visit his mother in Georgia. It emerges her perfect life isn’t what it seems.

Leah Peebles recently moved from her parents’ home in Texas to Albuquerque, NM, for a fresh start after years of struggling with drug addiction. Though she came from a supportive, tight-knit family, Leah had turned to drugs to cope after being molested as a toddler and raped as a teenager. Clean for the first time in years, Leah is eager to start her career as a hairstylist and get her life on track. But just a few weeks after arriving in Albuquerque, she steps out one night for a date and never returns. When the Peebles family feels the police are too slow to respond, Leah’s father decides to take matters into his own hands and hunt for her himself. He discovers Leah has fallen back into drugs and, worse yet, has turned to prostitution to support her habit. Rumors abound and the Peebles fear Leah has fallen victim to foul play. As he traverses Albuquerque’s underworld, seeing things he never thought he would, Mr. Peebles remains determined to search until he can bring her home.

35 year-old Jesse Capen vanishes on a camping trip in Arizona's Superstition Mountains. While law enforcement searches the vast wilderness, his family finds a huge secret on his computer. His disappearance may have to do with the legend he is chasing.

Bob Wykell is no ordinary 66 year old retiree. He loves flashy cars and makes good money restoring and selling classic vehicles. In February,1996 Bob tells friends he is about to close on his dream car. Then he drives off and is never seen again.

Jessica Heeringa is working the night shift at a gas station. When a customer arrives just before closing to find the store empty, investigators believe she's been abducted. It's a case that reveals Jessica's biggest secret and the many men who adored her

Twenty-one-year-old Kortne Stouffer vanishes from her bed one night following a couple of scuffles with neighbors and friends. Investigators pursue various leads, but the young woman is nowhere to be found, and her family clings to an endless hope.

Investigating the disappearance of Michele Whitaker who vanished after hitching a ride from a truck stop.

When 17-year-old Kara Kopetsky doesn't come home from school one day, her family panics. Foul play is suspected and a series of unsettling clues surface. But the leads grow cold until a month later when another local teenage girl goes missing.