Veterinarian Michelle Oakley is preparing for another harsh winter in the Yukon Territory. But before the snow gets too high, she wants to show her daughter, Sierra, the ropes of animal care. First, they perform a checkup on an 8-month-old puppy weighing in at more than 100 pounds. Then they work together to keep a bighorn sheep alive. The duo later visits an orphaned bear with a raspy lung. Sierra holds her own and leaves everyone impressed. Do we have the next Dr. Oakley on our hands?

It's mating season in the Yukon which means Dr. Oakley is busier than ever. She gets her hands a little dirty first to diagnose Priscilla, a cow who can't seem to get pregnant. Then, she gets a call from the Yukon Wildlife Preserve to help with a tricky case of a young caribou bull with growths on his nose. Then it's off to the next appointment, but this one is different. Mating season isn't in the cards for Dr. Oakley's dog, Daisy Mae Lover-Pants, and the time has come for her to get spayed.

Winter weather in the Yukon has come, and the cold temperature brings in some serious work for vet Michelle Oakley. Michelle makes a house call to a blind farmer who has a male goat that hasn't been able to breed. Then, Dr. Oakley is tasked with trying to move a herd of horses away from the highway and attempts to corral them by helicopter. Next Michelle heads down to the American Bald Eagle Foundation to perform a check-up on a very uncooperative owl.

A near fatal emergency brings Dr. Oakley to her home clinic where she rapidly works on a dog with a face full of porcupine quills. At her satellite clinic in Alaska, Dr. Oakley improvises with foam piping to make a wing splint for an owl.

Dr. Oakley stops at a local farm to run some tests on horses that may be at risk for a highly contagious disease, transmitted through the bite of horse flies. Then she pays a visit to the angriest muskox in the Yukon for a routine check-up, but he doesn't plan on surrendering without a fight. Later Dr. Oakley helps a devoted dog owner figure out the best options for his sick yet beloved family lab suffering from a chronic cough caused by a blocked windpipe.

Dr. Oakley has a full slate of home clinic visits with an angry cat that may have diabetes and a dog with an uncomfortable anal gland problem. Then, a definite rarity in these parts is an exotic 38-year-old blue and gold parrot in need of a nail and beak trim. But first up is Skippy, a reindeer of concern to the Yukon Wildlife Preserve because after two surgeries, his umbilical hernia continues to reappear. Can Dr. Oakley relieve him of his discomfort?