A climbing accident and a rare condition bring two young couples into the ER on Valentine's Day. Dr. Campbell must deal with a 10-inch blade sticking out of a patient's chest, while Dr. Theoret is faced with a heartbreaking case.

Dr. McKnight tries his best to diagnose a patient who is deaf and blind. Deborah, the ER’s social worker, plays detective to track down the identity of a “John Doe”.

The full moon takes its toll on the ER as it is threatened to be overwhelmed by traumas. Dr. Shirzad treats a young ER nurse who collapses on duty, and Dr. Campbell is faced with a doctor’s most difficult decision.

Paramedics Rick and Kelly hit the streets of Vancouver. Staff must deal with violence and drug abuse in the ER, while Dr. Rose confronts the horror of a multi-vehicle accident.

It's a shift of give and take as Dr. Campbell receives a patient with severe head injuries from the Air Ambulance. An ER nurse is given a medal for her military service, and the family of a deceased patient provides a stranger with a precious gift.

Yasmin takes a Unit Coordinator-in-training under her wing as the ER's veteran social worker begins her last shift. Doctors Campbell, Shirzad and Lee mentor the next generation of ER physicians.