Construction workers have inadvertantly released Achira, a ghost that can spread disease. The only ones who could stop this ghost are the Ghostbusters, but they have long since disbanded. In fact, only Egon is still in New York City. He is now teaching a college class, but his four students may prove very helpful against this nasty ghost.

Egon builds new and improved ghost busting equipment for the new team. While they search for Achira, Eduardo again sees Kylie, who has been possessed by Achira.

A Rabbi's son creates a Golem to defend against temple vandalism. But the Golem grows to strong to be controlled, forcing the EGB to come up against this violent force.

The EGB will have to face their inner demons when they come up against a ghost that can bring people's fears to life.

Characters from a horror novel are attacking innocent people.

A thief has gotten ahold of a pouch containing ancient runes, which a demon uses to enslave innocent people in his realm. The EGB have to catch this thief and rescue the demon's slaves.

A demon takes control of Roland and forces him to build a deadly mechanical host vehicle.

The EGB are on a job to bust a ghost, when they find the ghost is the house they're in and intent making two trapped children it's next meal.

Ghostly clowns are on the loose and feeding on laughter. Eduardo traps one of them, but then he starts to turn into one of them.

Everytime someone looks at the strange orb, a ghost appears to steal their eyes. Problem is, a museum is about to put the orb on display.

Janine attempts to make Egon jealous by going on a date with another man. Unfortunately, the man she dates is a bug demon in disguise and looking for a queen.

Ghosts are rampaging through the city and the EGB's equipment can't stop them. But a mysterious Piper claims he can.

A ghost capable of granting wishes comes to town in the form of a salesman, only his results are far from what people wanted. Eduardo unfortunately becomes his latest victim when he gets placed inside Kylie's cat.

A gremlin is on the loose, causing trouble throughout the city. While working to catch this gremlin, the EGB are arrested.

The equipment-less EGB have to protect a small town from the Jersey Devil.

A ghost capable of sucking all the water out of people is on the loose.

The EGB's hunt for a Banshee gets complicated when the Banshee's sister puts a spell on Roland.

Kylie gets transported to a future where a ghost named Tempus rules over humanity. While she meets a group of resistance fighters, the others have to prevent Tempus' take over in the present.

The weather in New York City is made a lot worse when a spirit called the Harasvelg arrives.

A Demon seed inhabits a Professor's plant, and takes over the building. The plant is destroyed, and the demon takes on another plant, in the park. Kylie thinks this demon is a helpful Amazon Plant, however she is wrong. It's really a civilization destroying demon inhabiting a seed. Can the EGB's stop Kylie before she has a chance to freeze it and send it back to the Amazon?

A recently released Leprechaun is trapping people in his pot of gold and Mayor McShane is his next target.

A ghost starts taking over people's bodies by pulling their souls into a mirror. When the others get trapped, it falls to Kylie to save the day.

Slimer gets trapped in the containment unit (and Peter Venkman isn't even here to see it), surrounded by some very vindictive ghosts that remember him, including a demon named Surt who wants to bring about Ragnarok. Eduardo goes in to save Slimer, while the rest of the EGB has to bust a demon hound in the Firehouse.

When Kylie was a child, a friend of her's mysteriously disappeared. Now, a ghost who looks like him has turned up. To stop and save him, Kylie calls upon a ghost the Real Ghostbusters captured years ago: the Grundel.

The EGB find their nightmares becoming more real when a ghost tries to leave the dream world and enter ours'.