Guests: Gaby Hoffmann and Téa Leoni. Two guests whose lives have been shaped by family mysteries are introduced to biological ancestors they never knew they had thanks to genetic detective work.

Join Larry David and Bernie Sanders, who learn they have more in common than they thought.

Guests: Carly Simon, Christopher Walken, and more. In this episode, three guests each learn about a grandparent whose real identity and background had been a mystery to them. Along the way, two of them also discover that their close relatives were on the wrong side of history.

Guests: Bryant Gumbel, Tonya Lewis-Lee and Suzanne Malveaux. Three African-American guests delve deep into their family trees, discovering unexpected stories that challenge our assumptions about black history.

Guests: Questlove, Dr. Phil and Charlayne Hunter-Gault. Three guests of disparate backgrounds dig into their Southern roots, where slavery and its aftermath shaped families both black and white.

Guests: Ted Danson, Mary Steenburgen and William H. Macy. Three mainstays of modern-day Hollywood discover family legacies that predate the United States itself.

Guests: Ta-Nehisi Coates, Ava DuVernay and Janet Mock. Three guests who have helped to redefine Black America in the last decade find their identities challenged as they learn about their family origins.

Guests: Scarlett Johansson, Paul Rudd and John Turturro. In this episode, three guests explore the tremendous challenges faced by their immigrant forebears.

Guests: Lupita Nyong’o, Carmelo Anthony and Ana Navarro. Three guests explore how their family trees were shaped by political turmoil and violence, discovering sometimes unexpected ancestry along the way.

Guests: Amy Schumer and more. Guests who have found fame mining their family stories for comedy learn about ancestors who overcame immense suffering.