When the head of a team of astronomers is commits suicide, their predictions of a meteor's collision become public. As panic sweeps the world both mortal and vampire populations face their personal fears. Some of those fears lead to unusual actions.

When Nick saves Schanke's life during a fire fight, Schanke can't help but notice Nick has taken up flying. Despite Nick's hypnotic suggestion to forget what he saw, Schanke begins investigating Nick's past. Natalie can't deflect him and Janette's attempts to hypnotise him fail. The trail soon leads him to conclude his partner is a vampire and from there to LaCroix. The question is, what is LaCroix going to do with the inquisitive Schanke?

Nick investigates the death of a young doctor when Natalie is unable to determine the cause. Intrigued by the doctor's experiments in near death experiences, Nick secretly agrees to "go under" in an attempt to reconcile his own past. But the experiment goes awry and Natalie must find a way to bring Nick back form his altered state of consciousness.

When an anonymous tip leads NIck to a "headless corpse" in the Raven, it is only the beginning of a deadly game, with vampires as the target. Nick soon discovers the ultimate target in these murders is LaCroix. Anyone and everyone who is close to LaCroix are being killed. When LaCroix reveals that the perpetrator is Divia, his daughter and master who he betrayed long ago, it becomes a race against time for Nick to find her before she comes for him or LaCroix.

Natalie's research leads her to believe she might be able to cure Nick, if he's willing to take the risk. While taking the wonder drug, Nick and Schanke unofficially investigate the suicide of another cop. Is Nick just having incredible hunches or is the drug not quite what it seems?

Upon leaving his wife, Schanke moves in with Nick, expecting to lead a wild bachelor's life with his partner. But the two are soon at odds over the investigation of a wealthy business-man's murder. Feeling that Nick is once again trying to keep one step a head of him, Schanke vows to solve the case on his own. Acting on a sudden revelation while drowning his sorrows in liquor, Schanke rushes to apprehend the murderer without his partner and captures the killer single-handedly. Or, so he thinks.

David Constantine is the next in line to become "Don" of the city's biggest crime family, but after witnessing a lifetime of killing and bloodshed, he just wants to live a normal life with his family. Nick Knight understands David's dilemma, as he wants to get away from his self-proclaimed father, LaCroix. However, David's great grandfather will stop at nothing to ensure his grandson's enshrinement, even going to LaCroix for help. This sets up a Father's Day showdown between David and his great grandfather and Nick and LaCroix.

Valentines day not only brings out a killer who lures in women with romantic cards, but turns Nick's thoughts to Natalie, and LaCroix's to past love. All this love in the air is bound to be dangerous.

Highly respected parole officer, Casey Brooks, is the prime suspect in the investigation of a murdered Vietnam veteran. Nick Knight is certain he has encountered Brooks in the past and flashes back to wartime Vietnam to discover Brooks' true identity, along with the dark secret that could ruin the parole officer's career. But the investigation changes course when Nick's prime suspect nearly becomes the next victim.

Nick and Schanke apprehend a convicted murderess on the run from Texas authorities when an anonymous tip leads them to a rental car agency. Nick believes she may be innocent, however, he must prove it before she is extradited and put to death for her crime.

A bullet wound to the head lands Nick in the emergency room, where with no pulse, no heart rate, and no brain activity, he is declared dead. Fast action by Natalie and LaCroix, brings Nick back to life. While his physical wounds are healing, his mind is another matter--he has amnesia, and therefore no memories of who he is or what he is. Both Natalie and LaCroix see this as a chance to acheive their goals for Nick. Who will win this little contest, and what will be the price? Meanwhile, Nick must find the killer before he strikes again, as well as find out who he really is.

A scientist is murdered and a lab rat escapes when industrial espionage goes awry. But far worse things begin to happen when the lab rat, infected with a newly engineered virus becomes Screed's next meal. Designed to combat HIV, the virus becomes lethal to vampires as it multiplies and intensifies each time they "feed". As the virus spreads rapidly through the vampire community, it infects Vachon, Nick, and LaCroix. Nick races agains time to find the killer - while Natalie struggles to find a cure.

Soon after a psychopathic killer, Peter Barlow, escapes from a mental institution, a patient's body is discovered on the hospital grounds -- the victim of a brutal and vicious murder. The following day another patient's body is discovered. Both crimes match Barlow's M.O., and Nick Knight is determined to prevent another murder. But, Nick's quick arrest of Barlow proves there is a different killer at large. Now he must find a new connection between the victims and the murderer.

A patron of the Raven is found dead, apparently killed by a vampire in unusual circumstances. The woman at the scene has no memory, and there are no clues. Nick must find the vampire-killer before he strikes again, while keeping Tracy out of trouble. For Tracy is aware it is a vampire, and is searching for the killer, too.

While investigating a series of bizarre murders, Nick discovers that an ancient evil from his past is behind the crimes. LaCroix, his former vampire master, has returned to the city in search of Nick, his one-time pupil The murders, coldly orchestrated by LaCroix, threaten to uncover Nick's sinister secret when he is arrested as the prime suspect. With the help of his partner, Don Schanke, and the department pathologist, Natalie Lambert, the only mortal who knows his true identity, Knight escapes. Now an outlaw, he must track down the killer and find LaCroix before he is forced to give up his dream of regaining his mortality.

Life imitates fiction when Emily Weiss, the best-selling author of a series of vampire novels, is attacked by a crazed fan. Her works are amazingly true to life, leading Nick to believe that she may know more about the vampire community than she says. LaCroix, the leader of the community, sees her as a threat and declares that she must die and Nick must carry out the decree. Nick, however, finds that he is falling in love with this woman. She is the only mortal capable of understanding what it is like to live in eternal darkness, and she would go willingly into his waiting arms if asked. The time has come for the truth and the fiction to become one, and her fate rests in Nick's hands.

A routine investigation into a suicide leads Nick and Tracy to an exorcist. As they witness an exorcism, Nick is overpowered by a terrible evil. Unable to control himself, Nick turns to LaCroix for help. But even LaCroix is powerless in the face of this evil, and at Nicks request, takes him to the exorcist to help free him from the Son of Belial.

While investigating the murder of a virtual reality software designer, Nick finds the vampire game he created fascinating. Inside the game, Nick finds the killer waiting, daring him to try and find him. Playing the game he searches for clues, but finds himself intoxicated by the vampire feeding instead, feeling his lust for blood and killing reawaken. The closer he gets to solving the crime, the closer he gets to wanting to losing control and killing again.

Someone is killing a number of homeless people and draining their blood. Then a museum guard is killed the same way and a special artifact is stolen, a Mayan cup that Nick believes can help him become mortal again. Nick suspects that his old mentor Lacroix is in town and behind the murders. Forced into a partnership with the unbearable Detective Schanke, Nick has to face both Lacroix and the Homeless Killer while trying to protect his friends.

Another serial killer, this time preying on young women who all attend the same church. In order to catch him, Nick must try to overcome his fear and loathing of the Church and its symbols. Meanwhile, flashbacks to 15th Century France show Nick's encounter with a young peasant girl doomed to become a martyr when her claims that God spoke to her result in the Church branding her as a heretic and condemning her to burn at the stake. Nick offers her his version of immortality, but she refuses in favor of her own belief in life after death.

A young woman dies, and all evidence points to suicide. Nick, however, has a gut feeling that it was murder, but seems unable to prove it. Added to his stack of unsolved crimes, it makes Nick question his own feelings of self-worth, especially after hearing about another, real suicide: that of one of his "old friends". Nick must search through his memories of their relationship of centuries past to determine why she killed herself, and why he shouldn't.

The two day search for Natalie Lambert's young niece ends when the missing girl's body is discovered in the woods. After Nick Knight rescues the alleged killer from an angry mob of vigilantes, a blood test and line-up fail to provide enough evidence to hold him. Removed from the case because of her ties to the victim, Natalie questions the results of the lab work. When the suspect suddenly dies, Natalie performs her own lab test and uncovers another murder.

A drive-by shooting could ignite a gang war, but Schanke's got stars in his eyes moonlighting on a movie set. Then the star of the movie steps right into the killer's path. Will Nick and Schanke find the renegade killer before this movie star is history?

Serena, a victim of Nick's immortal bite from the past, has a plan to regain her mortality. According to ancient legend, a vampire will become mortal if she bears a mortal's child. But to conceive, the mortal must possess an extra chromosome and will be murdered soon after conception. When Trilling, who possesses the magic chromosome, is arrested for murder, Serena provides an alibi to get him out of jail. Fully aware of Serena's plan, Nick struggles to solve the murder -- torn between reconciling the wrong he did Serena and preventing yet another murder. But his actions, along with the reasons behind them can never be revealed.

Nick's discovery that Tracy's mystery man, Vachon is a vampire, complicates an already complicated situation. Luckily Vachon and Tracy's mutal attraction saves Tracy's life. However, Tracy's awareness of vampires, and Vachon's penchant for running from his responsibilities place them all in danger as the bomber plots to use Tracy in his next bombing.