Rex is a regular teenager, except he has nanites that he can control. He works for Providence to help contain people who have been infected by nanites and are raging out of control.

Nanite activity is increasing around the world. Rex decides to go to one area for Spring Break. He befriends a lonely young woman with a secret agenda.

Rex vanishes, and Breach is the only person who knows where he is. As Rex explores his surroundings, Holiday tries to figure out where Breach has him hidden.

Rex is pursed by a killer EVO bunny. And his life is further endangered as he attempts to go to Prom.

Rex encounters Hunter Cain. A man determined to destroy all Evos, including Rex.

Van Kleiss steals Rex's nanites which powers up Van Kleiss and Rex powerless. Van Kleiss gains new abilities and attacks Providence. Meanwhile Rex tries to get his power back and finds something in his system.

Providece is being rebuilt. Van Kleiss turns Noah into an Evo sending Noah on a rampage throughout the city. Rex chases after his friend while Van Kleiss is free to pursue his real objective.

Rex and Six attempt to retrieve nuclear material from a research sub. They encounter an underwater colony of Evos.

With the dome about to fail, Rex and Bobo go to Kiev to repair the shield. Van Kleiss arrives to form an alliance with Noface.

In the middle of a battle, Rex suddenly produces new builds. As he's being examined, a mysterious stranger arrives who claims to be Rex's brother - Caesar. He claims to have sent the schematics for the builds.

Rex and Bobo head to Mexico where a local group is freeing Evos caught by Providence. Rex is poisoned and must recapture an Evo to find the cure.

Rex and Caesar visit their Abuela in Mexico. Hunter Cain is back.

Breach is targeting the girls of Rex's life: Cricket and Circe! Or is she?

A researcher claims to have a cure for incurable Evos. Holiday leaves Providence in an effort to save her sister, but Six is suspicious of this miracle cure.

Van Kleiss attach's a device to Breach which makes her more dangerous. Rex attempts to get her to switch sides.

Rex and Circe go to Abysus to get a Metananite before Providence can obtain it.

White Knight and his team break into Providence to keep Providence from restarting the Nanite Project that caused the Event. Secrets are revealed, and White Knight tells the team what is at stake.

Van Kleiss ended up in the past and is being pursued. He struggles to find a way back to his own time.

Providence makes its move against Rex and company to get all the Metananites.

Providence has changed during Rex's time jump. Black Knight is now in charge. Rex does not like the new direction Providence is taking.

Jungle Cat returns to assist the team in their efforts to infiltrate Providence as the Consortium reunites for the first time since the Event.

Some of Rex's enemies escape from prison seeking revenge.

Rex must risk everything on his ultimate build in the final battle with the Consortium.

An Evo infects regular people, building army. Rex must cure the Evo, or Manhattan will be "cleansed."

Rex absorbs too many nanites requiring an emergency visit to a secret Providence base to store the excess nanites.