When Prime Evil learns that Belfry wants to be bigger he disguises himself as the magician Monroe and hands him an amulet to help him. When Belfry shows the amulet to the Ghostbusters it shoots out a beam, shrinking them. Belfry must learn a valuable lesson as he helps Jessica and Futura save the Ghostbusters.

The Ghostbusters, in an effort to get away from it all, take a vacation in the wilderness with Corky. However, the evil ghosts Benny and Clyde have stolen a statue for Prime Evil and are hiding out nearby. When Corky is captured by the gruesome twosome the Ghostbusters rush to his rescue.

At Hauntquaters, Prime Evil taps the power of four mysterious urns unleashing the spirits of the four phantoms of Babylon! With their power the villain plans on sending the world back to the time of Ancient Babylon in a nefarious plot to take over the world. The Ghostbusters must travel through time to stop him!

Professor Von Ziflin locates the Diamond of Gloom, which is promptly stolen by Prime Evil's goons. The Ghostbusters retrieve it from Hauntquarters and must return it to its temple before the full moon or the Earth will be forever cursed.

When the mysterious Vodun appears Prime Evil sends Scared Stiff and Haunter to capture the large creature. In an unexpected set of circumstances Eddie finds himself chained to Vodun with their enforced adventure giving both the monster and human a new perception of the other.

Prime Evil sends Sir Trance-A-Lot into the past to capture Jake's great-grandfather, Marshall Clint, and bring him to Hauntquarters. Prime Evil places a curse on Marshall Clint, a werewolf curse that now curses every generation of the Kong family!

The Ghostbusters offer Corky the position of honorary Ghostbuster. Unfortunately, this honor goes to his head and Corky steals the Ghost Buggy in order to hunt down ghosts and impress his friend. When the Ghostbusters realize that Corky and his friend are missing they pursue the pair to the Hauntquarters.

As Belfry's cousin Beauregard visits Ghost Command, the Ghostbusters receive a phone call inviting them to attend a party. Jake, Eddie and Tracy leave for the party little knowing that there is no party, and only the evil powerful Mr. Squid awaits them.

When Prime Evil sees a comet passing through space he sends Captain Long John Scarechrome and his band of pirate warriors to capture the comet and direct it towards Earth. The Ghostbusters have no idea what Prime Evil's plan is until the comet strikes the earth and the largest volcano ever seen appears.

The Ghostbusters' peace and quiet is broken when a phone call summons them to Scotland where a young boy has accidentally released the Spirit of Slort, the King of the Trolls. When the Ghostbusters are overpowered by the power of the Troll they look to their fathers for help and the original Ghostbusters come out of retirement.

An evil witch named Sassella arrives at the Hauntquarters claiming that she will scare the Ghostbusters into another line of business by transforming them into five-year olds. The original Ghostbusters once again rush to their sons' rescue with a horde of Prime Evil's ghosts standing in their way.

Prime Evil desires to locate a decoding box that was accidentally dropped from space into the ocean. With the decoding box in his possession he believes that he could use it to learn every secret that the Governments of the world possess. When a new submarine is revealed to have been built Prime Evil sends Captain Long John Scarechrome to steal it.

Eddie, wishing to be a great painter, asks Madame Why to conjure up some magic paints for him. When she refuses Prime Evil takes advantage of the situation and sends Eddie some magic paints. It is not long before Eddie has painted a masterpiece, a masterpiece that could lure the Ghostbusters to their doom.

Captain Long John Scarechrome shows Prime Evil a map leading to a non-existent buried treasure. Knowing that the route would take them to the planet Doom, Prime Evil sends the map to Ghost Command. As Eddie and Tracy head off to find the treasure, Jake and Jessica realize their friends are missing.

Count Freeze arrives at Hauntquarters informing Prime Evil that he can defeat the Ghostbusters. Prime Evil agrees and it is not long before Jake and Tracy are frozen by the Count in Castle Blackstone. Unknown to the Wizard of Castle Blackstone, Prime Evil offers Eddie the chance to become a super hero.

In the future the evil cyborg Cyman sends a ghostly being into the master computer of the Star Base Crusader in attempt to get revenge on Futura. The Ghostbusters travel to the future, shrink themselves down and enter the master computer, not knowing what lies ahead of them.

Prime Evil sends Haunter to steal a recently discovered dinosaur egg, believing that he can raise the creature and conquer the earth. The Ghostbusters journey back to the past with the egg to reunite it with its mother before it hatches.

When Prime Evil discovers mole creatures living in underground caves with an entrance at the North Pole he and Apparitia see an opportunity to overthrow the Earth. Belfry and the Ghostbusters attempt to stop Prime Evil and convince the mole-like people that they are friends.

When Jake and Jessica go on a date Eddie and Tracy go to the rescue of a little girl which turns out to be a trap laid by Prime Evil and find themselves in an old ghost town where they meet a good ghost named Sheriff Stumbleweed and learn that Prime Evil has brought together the most fearsome ghosts from across the universe.

The Ghostbusters go back in time to ancient Rome to aid Madam Why's great ancestor , Tonya and prevent Prime Evil's ghosts from stealing a magical wreath owned by Julius Ceasar. It is not long before the Ghostbusters are taking part in a deadly chariot race against Marcus Phantamus.

When Prime Evil sends Fangster to retrieve the Aztec Medallion, the Headless Horseman of Sleepy Hollow, a former hench-ghost of Prime Evil arrives at the Ghostbusters Ghost Command warning them of the danger. But can they trust him?

When the Ghostbusters receive a call from the Mayor of Transylvania they learn that much to everyone's surprise, the famous Count Dracula has returned! The Ghostbusters travel to Transylvania but even they are not prepared to fight one of the greatest villains of all time.

Always trying to get the latest scoop, Jessica receives a note and decides to meet with the mysterious person it came from. She is soon captured by the Phantom who wants to use her TV show to tell the people to surrender. As he threatens her, the Ghostbusters battle their way through the New York nightmares!

In his latest plan to rule the world Prime Evil decides to amplify Belfry's sonic blast. However things do not go according to plan when his sister Prime Ordeal and her bratty child Snookums arrive. As the Ghostbusters fight to save Belfry, Prime Evil is occupied with many other problems!

Fangster goes out on his own and locates the Lost Bone of the Werewolf. With the mysterious bone he plans to complete a magical archway that can transform dogs into savage werewolves. Fangster must not only overpower the Ghostbusters for his plan to succeed, but also face the wrath of Prime Evil.