Thirty-two-year-old Michele Whitaker is leading a troubled life when she disappears without a trace; her family and police investigate every possible lead for six years, then, a telephone call gives them the answers they're looking for.

17-yr-old Chris Daigle vanishes shortly after leaving Hightower High School for the day in Missouri City, Texas. Family members and law officials spend years dissecting the weeks and months leading up to the day the baseball all star disappears.

When Dena Raley-McCluskey vanishes from Modesto, CA, investigators focus on her ex-boyfriend with whom she had a known tumultuous relationship. Scant clues stump the police for years until an unexpected break in the case uncovers the shocking truth.

Teenagers Cheryl Miller and Pam Jackson go out to enjoy the first day of summer break in the small town of Vermillion, South Dakota and vanish. Although rumors spread for years, the families never give up hope. Then one day, the mystery is revealed.

When Lynda McClelland goes missing from her home in Forest Hills, Pennsylvania she leaves behind three beloved grandchildren and a daughter who is heartbroken. An agonizing search uncovers answers that lie painfully close to home.

Charlotte Moriarty and her infant son take a five-minute stroll to the market on the small island of Oahu, Hawaii, and never come home. It will take more than 30 years to find out what happened to the mother and baby on the day that they vanished.