Cocky sisters challenge best bros in the Pepperdome. But the sauce proves too hot to handle for one team, resulting in the first-ever TKO.

Gym-loving women power through the pain while bartending besties attempt to knock back the heat.

Powerlifting besties battle a duo whose on-and-off status is ever-evolving, and they'll have to stay together to face a slate of hot sauces while the powerlifters try to grab the grand prize.

Two teachers get schooled by the fiery inferno, while a rapper and his manager break into a sweat.

The Pepperdome is on fire as a young couple goes head to head against a pair of fishing cousins; Chef Willie and Sean unleash their tackle box full of ferocious hot sauces, even the simplest and easiest questions become next to impossible.

A muscle-bound competitive eater and his new fiancé appear to have the edge in the Pepperdome as they go against a duo of brothers who'll have to put their sibling rivalry aside if they want to conquer Sean and Chef Willie's malevolent hot sauces.

Chaos breaks out when two teams of best friends enter the Pepperdome. Sweat will drip, dance moves will bust out, and one shirt will desperately need dry cleaning, all for the chance to win $25,000.

A contestant is dragged to the Pepperdome by his cousin. Two bffs think they're immune to the spice and quickly get hit with the heat.

A pair of newlyweds go head to head against a pair of stand-up comedians to see who has the last laugh in the pepperdome.

Some grandmas show determination when they come to the Pepperdome to battle.

A contestant is dragged to the Pepperdome by his cousin; two bffs think they're immune to the spice and quickly get hit with the heat.

Two former baristas go head to head in the pepperdome with two wine-loving buudies, but soon as chef Willie starts serving up pain, it becomes clear the pinot has nothing on peppers, and caffeine is no match for capsaicin.

Firefighters enter the pepperdome with confidence but struggle to put out che Willie's blazing inferno; drag queens come in as divas, but the sauce quickly turns them into disasters.

Party animals get wasted by chef Willie's chicken wings; Models who are best friends struggle to keep their composure and answer questions; only one team will conquer the sauce for a chance at $25,000.

Rock and roll bandmates go up against two energetic DJs

Two self-described nerds do battle in the Pepperdome against a young mom and her dad; Poppy has to power through the pain to prevent the nerds from taking their revenge.

Fiery identical twins take on saucy drag queens in the Pepperdome. It's duke it out or puke it out in this competition during which one player becomes very intimate with the "Hot Ones" spit bucket.

Two teams of best friends enter the Pepperdome with confidence, but Chef Willie's demonic sauces bring them down hard and early. Does either team have what it takes to mount a comeback from the very bottom of their stomachs?

Two comic book guys take on two "twerking" best friends. The mighty Constrictor Sauce knocks the comic book guys to their knees, but they continue to fight for justice and for $25,000.

In this battle of the sexes, two teams duke it out against the catastrophic concoctions from Chef Willie. One will extinguish the fire and take home $25,000 while the other goes down in flames! And it all goes down in the Pepperdome!