After the tragic death of her sister, Yetunde Price, Serena is overcome by grief and depression, leading her to drop out of the top-100 rankings. Serena enters the 2007 Australian Open where she battles her emotions and tough competition.

The isolation of tennis begins to take a toll on Serena, prompting her to enhance her game with the help of a new team. Team Serena must rally around her after life-threatening health problems to prepare her for the 2011 US Open.

After losing in the first round of a Grand Slam for the first time in her career, Serena hires a new coach, Patrick Mouratoglou. Serena reflects on the similar path followed by her friend, Roger Federer.

Serena makes her return to Indian Wells, a tournament that holds painful memories for her and her family. Serena, her sisters, and Mary Joe Fernández, share firsthand accounts of the event, which led Serena to boycott Indian Wells for 14 years.

After nearly two decades of overcoming the odds and playing in the shadow of her older sister, Venus Williams, 17-year-old Serena Williams, who began her tennis career on the public courts of Compton, wins her first grand slam at the 1999 US Open.

As Serena struggles to follow up her first grand slam, Venus wins four major titles in two years. Serena eventually finds her groove, but it means going head to head against the top player in the world, her sister, and only one can be the winner.

As she begins a new chapter of her life, Serena enters the end of her career. After giving birth to her daughter, Olympia, Serena returns to the court before announcing her retirement from the game of tennis ahead of the 2022 US Open.

During the Italian Open, love is in the air when Serena meets Alexis Ohanian, co-founder of Reddit. Shortly after getting engaged, Williams heads into the 2017 Australian Open with hopes of winning her 23rd Grand Slam, all while carrying a secret.