Cuomo goes inside a maximum-security prison for an exclusive interview with one of America's most notorious serial killers, Joel Rifkin. Cuomo is Rifkin's mind-hunter, asking him tough questions about his sordid sex life, why he brutally murdered 17 women and how he was eventually caught. Beyond the horrors of the killings themselves, Cuomo tries to understand what motivated Rifkin, who is serving more than 200 years for his grizzly yet methodical crimes.

Julie was abducted from her church parking lot by a stranger. Gabrielle was attacked as she walked home from work alone at night after the Uber app on her phone malfunctioned. Despite the growing attention on sexual assault, an alarming number of rapes go unpunished; more than 98% of the time the perpetrators never spend a single day in prison. Cuomo hears the firsthand accounts of rape survivors and examines what hurdles they face to get justice.

When Debra Newell clicked on John Meehan's online dating profile, she thought she'd finally found the perfect man. He said he was a doctor who volunteered his services in Iraq, but as their relationship grew, Debra began to have an uneasy feeling. Cuomo unravels the twisted tale of what happened to Debra when her promising love story went horribly wrong and somebody ended up dead.

Three women a day are killed by a former or current husband or boyfriend. Nicole Beverly is desperately trying to avoid that fate. When she met her husband in college he was a football star and they were in love. She never imagined the relationship would turn violent and he would end up holding a gun to her head. Kevin is in prison for his violent attacks on her. Now his release date is coming up and a judge will decide if he should go free. Cuomo follows Nicole as she goes through the court system, trying frantically to keep him behind bars. If he gets out, she is convinced he will kill her...so she is prepared to go on the run and into hiding with her two sons. Cuomo goes inside the epidemic of intimate partner violence that can turn lethal for so many women.

Like most identical twins, the Spahalski brothers have a lot in common... but they may be the only identical twins who have both separately committed murder. Cuomo meets face-to-face with Robert Spahalkski inside a maximum-security prison where he's serving 100 years to life for four murders. The host confronts him with details of his crimes and tries to glean insight into the cause of his murderous urges. Could the desire to kill be a genetic trait? Cuomo tries to find some answers to the age-old question of nature versus nurture.