Jem stars in Howard Sands' new movie, part of the prize she and the Holograms won in the Battle of the Bands. But Pizzazz convinces her father to buy the movie studio making the film and give ownership to Eric who quickly seizes control of the film and adds the Misfits to the cast. Eric places the focus of the film on the Misfits and Jem and the Holograms are relegated to supporting roles. Finally fed up with the Misfits' disruptive behavior, Jem and the Holograms, along with Video, quit the movie. But Jerrica receives shocking news about Starlight Girl Ba Nee, who has been diagnosed with a rare optical condition that will leave her blind within a matter of months.

Horrified at the news of Ba Nee's impending blindness, Jerrica learns from her doctor that there is an experimental laser surgical procedure that could save Ba Nee's vision. However, the cost of the surgery is a staggering $250,000. Having canceled all their tour dates to star in the movie, Aja hits on the idea to divert funds from Starlight Music to cover the cost. But when they arrive there, they find the building closed down and without power. Joanie, the business manager of Starlight Music, tells the group that Eric has drained huge sums of money from Starlight Music to promote the Misfits' movie. Left with no other option, Jem and the Holograms are forced to return to the movie. Eric's demands push the group to their limits once again, especially when Jem nearly falls from a set display suspended several dozen feet in the air. Video records the accident hoping to use it to shut down the movie's production, but Jem pleads with her not to, because of Ba Nee's surgery.

During a dangerous motorcycle scene for the movie, Kimber is caught in the middle of a series of explosions set off by Roxy and Clash, and is almost killed. Infuriated, Jem and the Holograms quit the production permanently, along with most of the crew who witnessed the accident. Jem rallies the crew to continue the movie, but with a new plot and title: Starbright, while the Misfits' demanding behavior finally causes what remains of the original crew to walk off the set. Meanwhile, a disguised Clash sneaks onto the set of Starbright to spy on the cast and crew, only to be exposed by Georgia, the makeup artist who had recently quit the movie as well. Clash steals the tape of Jem's accident, but Jem and the cast manage to recover it after a lengthy car chase. Starbright proves to be a box office smash, while the Misfits Movie bombs quickly. The Holograms' first share in the box office proceeds go to pay for Ba Nee's surgery, which is a complete success.

Jem and the Holograms are invited to perform at a concert benefitting the victims of world hunger. When The Misfits learn of the concert, they try to horn in. Sally Brand, the woman behind the World Hunger Shindig tells them they can perform, but can't be on the live album unless another group backs out. Eric Raymond schemes to keep the Holograms away from the concert and to make a tidy sum of money for himself in the process.

The Holograms are invited to perform a special concert in China. The Misfits tag along and take notice of Jem's reluctance to part with her JemStar earrings while going through customs. They steal the earrings, leading Jerrica and the Holograms in a race against time to recover them in time for the concert.

Jem and The Holograms take a much needed vacation to a Colorado ski resort owned by Rick Franklin, an old friend of Howard Sands. Mr. Franklin tells the Holograms that his resort is being threatened by another resort owned by Eric Raymond. Eric and the Misfits attempt to sabotage the resort, in order to bankrupt Franklin so that he will sell the resort to Eric. Meanwhile, Rio and Swenson, the handsome ski instructor face off in a contest for Jem's attentions. In order to settle the matter of which resort controls the mountain, The Holograms and The Misfits face off in a ski contest.

Several girl groups from all over the world are invited to take part in a rock fashion contest headed by Italian music promoter, Tony Cassini. Shana is a bit nervous about the competition and The Misfits try to rattle her by chipping away at her confidence. But the last laugh is on them when their own designer drops out of the contest. Unfortunately this prompts them to get Zipper, Eric's hired henchman to steal the costumes Shana's designed for the Holograms.

The Holograms and The Misfits become so focused on beating each other at the upcoming annual Music Awards that they neglect their duties to the Starlight Girls. Deidre, one of the girls is so hurt by this she runs away. Ba Nee, not wanting Deidre to go alone decides to come with her, and Krissie goes as well to keep an eye on them. Meanwhile, Video introduces the Holograms to Giselle Dvorak (Danse), a talented stage dancer, who has a special request for them. Eric Raymond hires Techrat to cause trouble for the Holograms. The girls run away to the Misfits, who anonymously report that Jerrica is mistreating her Starlight Girls. At Starlight Music, Jem finds out from Lin-Z that the Haven House Benefit is the same night as the Music Awards and that missing the event would hurt her chances to win this prestigious award. She backs out and goes home only to learn about the runaways. The Holograms search everywhere but there is no trace of them. Feeling guilty for ignoring them, Jem decides to perform at the benefit anyway with the hopes that the girls will hear about it and come home.

As Jerrica and the others continue their search for the girls, The Misfits stage a publicity stunt to garner more attention toward their appearance at the Music Awards. Deidre, Krissy, Ba Nee and their new friend, Danny run afoul of a couple of thugs, who force Danny to steal from a local electronics store for them. They manage to escape and are directed to Haven House, where Danse finds them and brings them to the concert. Techrat tries to disrupt the concert with a jamming device, but Danny catches him in the act. Meanwhile, the Misfits win for Best Musical Group and Pizzazz plans to gloat to Jem about the win, so they drive to the concert, only to find the audience cheering the performance. Pizzazz, silenced by the overwhelming sense of goodwill the concert has created, doesn't notice her award slip out of her hand to the floor, where it smashes into a hundred pieces.

The Misfits try to ruin the Holograms's new rock fashion book. When their initial attempts fail, Pizzazz persuades her father to buy the rights to the book, putting the Misfits in charge of the project.

Eric incites greed and scandal by offering a $100,000 reward for anyone who can reveal Jem's real identity, while both groups are in New York City auditioning for the lead roles in a Broadway producer's new show.

As Jem and the Holograms prepare to release their debut album, Eric hires Zipper to steal it, so The Misfits can use the material for themselves. Pizzazz sends the Holograms anonymous letters with clues that will supposedly lead them to the stolen album, but lead them into danger instead. When they retrieve the album, they place a tape of French-speaking lessons for Eric Raymond to trick him.

The Misfits and The Holograms compete in the "Battle of the Music Stars", a Battle of the Network Stars type event in Honolulu. Kimber is kidnapped, and the Holograms have to find her in time to compete.

Loosely based on the Mark Twain story The Prince and the Pauper, while touring the small European country of Morvania, Kimber meets Princess Adriana, the teenage heir to the throne who happens to look exactly like her. When Adriana escapes from her room, her power-hungry cousin Lexa hires her henchmen to track her down and bring her back. When Kimber and Adriana bump into each other, Lexa's henchmen discover Kimber (Who they think is Adriana) then kidnap her and lock her in a tower where she escapes. Lexa discovers that the real Adriana is with the Holograms so she uses the Misfits to lure Kimber to the hotel where the Holograms are staying and plant a bomb on the stage (to kill Adriana) and take over the throne. The Misfits gatecrash the party and save the Holograms from the bomb on the stage. The Holograms then rescue Kimber, Lexa is placed under arrest for conspiracy, and Adriana claims the title of crowned queen at last.

Jem and The Holograms are invited to perform at a concert in St. Thomas and travel aboard a luxury ocean liner to get there. Eric and the Misfits, who are convinced there's a publicity stunt going on, tag along to cash in on it. Later that evening, after giving a performance for the passengers and crew of the ship, Jem and the Holograms are tricked by the Misfits into hiding aboard a lifeboat under the misconception of giving the ship's captain a surprise for his birthday. But when the prank goes wrong, it maroons the Holograms and the Misfits on a tropical island. The girls, despite their rivalry must try to survive and get help from a hermit living on the island.

When Jem & The Holograms perform a song called 'Rock and Roll is Forever,' they infuriate an old singer named Bobby Bailey. However, Bobby turns out to be a man with a big heart but also a big problem. His flat is scheduled for demolition and Eric Raymond is behind it. Will Jem & The Holograms manage to help Bobby or will the wrecking ball win the day?

Starlight Music sponsors Indy 500 driver Martino Granzetti. When a crash lands Martino (and Rio) in the hospital, Jem & the Holograms manage to rebuild the car and Jem decides to race the car for the tournament. However, things turn nasty when Pizzazz enters the race and causes chaos on the track.

The Misfits plot to ruin The Jem Jam, a benefit concert Jem is planning, by tricking Luna Dark (a Cyndi Lauper-esque singer) into coming with them, while Krissy must deal with Lena Lerner's (a Tina Turner-like pop star) spoiled brat son, Dominic (who resembles a young Michael Jackson), and Ba Nee is sure that Randy James, a red-haired drummer for a Springsteen-like rock star, is her father.

Jem saves Luna Dark from Pizzazz's guard dogs, and the Misfits plot to ruin the Jem Jam, with help from Techrat. Meanwhile, Ba Nee goes to great lengths to prove that Randy is her father. Also, Krissy finds out that there's more to Dominic than she thought.

An eccentric artist, Fitzgerald Beck, is the art director for Jem and the Holograms' new video. Beck's art dealer is using his sculptures to smuggle stolen diamonds. The Misfits find this out and set up the sculptures to explode onstage while Jem and the Holograms are filming the video, leading the police to believe it was Jem and the Holograms and Beck who put the diamonds there. Jem and the Holograms must team up with Beck to find the actual culprit before the cops catch them.

Jem hasn't been heard from in some time and Jerrica doesn't seem to care. The Misfits waste no time capitalizing on her absence, especially when Owen Beech, the owner of Diskovery Records promotes a contest, awarding a Gold Album award and a new car, the Glitter and Gold Roadster to the winner. After an argument with Rio, the Holograms try to persuade Jerrica to make a new album to compete with the Misfits. Jerrica is somewhat resistant to the idea, feeling it may be too late to enter the contest, but when she overhears Eric making a comment that she ruined Jem's career, it galvanizes her to enter, and promises Owen Beech she and the Holograms will deliver a new album in time for the contest. The group decides to use the prizes for the contest as the theme for their new album and look called Glitter and Gold.

Roxy wins the lottery and goes home to Philadelphia to show off her new lavish lifestyle to her old friends. Meanwhile, Jem and the Holograms are in Philadelphia on a tour to promote literacy. What no one knows is Roxy is illiterate. Roxy decides to throw a bigger party than the Holograms and ends up without any money left because she didn't read the fine print on her contracts. In the end, she decides to learn how to read thanks to a book BaNee gives her.

Laura Holloway, a new Starlight Girl with a talent for music, falls victim to Bobby Braddock, a drug dealer at her school. Ashley plays an important role again, this time helping to confront Laura and eventually help the police catch Bobby.

A group of college students (including a high school friend of Kimber's) ask Jem to help a struggling radio station that they intern at, that a larger rival station wants to buy out and get rid of.

The Holograms plan to save an old opera house from being torn down. As they restore it for a special Halloween concert, the Holograms encounter spooks and ghosts.