Johnny drinks an unstable isotope so he can get sick and not have to study for a test for school. Unfortunately, not only does the isotope give him red spots and a purple tongue, if it's not cured within four hours, it's going to give him immense bloating, cause violent coughing, and eventually make him explode.

When Dukey explains how narration makes everything seem better, Johnny convinces Susan and Mary to make a reality warping megaphone, but it malfunctions.

Mr. Black and Mr. White ask Susan and Mary to design a new weapon, so they make a helmet that allows the user to control things with their mind. But it becomes a huge mistake when it's stuck on Johnny's head, and his obsession with a new video game now makes any inanimate object he sees turn into a monster.

Johnny buys a video game which turns out to be a military plot to recruit an elite team of super soldiers, and then he must join the fight against a group of renegade penguins who are losing their home to global warming.

After Johnny and Dukey send Bumper packing, they start to come against each other in a game of "Say Uncle".

Brain Freezer creates an army of snowmen, and only Johnny X can stop him.

Fed up with the lack of respect, Dukey has convinced Mary and Susan to turn Johnny into a dog. In the meantime Mary and Susan turn themselves into animals so they can get loved by Gil. It all goes wrong when Animal Control arrives and snatches them.

Johnny wants to buy an HDTV and the twins need an important ingredient for their experiment. The only solution: Enter Johnny in a professional wrestling competition so they can win $10,000, so they make Johnny a wrestling suit which allows him to spray stink gas from his suit.

Johnny and Dukey are transported into their favorite video game, Tiny'Mon, but they end up trapped and must defeat Blast Ketchup, and his Tiny'Mon Kadoomerang, to get back home, with only the seemingly useless Cuddlebuns for protection.

When Eugene finds out that Johnny is what stands in the way of him and Susan, he sets out to lock Johnny up forever as he tries to get the last ingredient for his sister's "Susan-hating lozenge".

Johnny is upset because the holidays that give free candy to the world are spread too far apart, so Johnny decides to start his own holiday, known as Kids Get Free Candy Day, and try to spread free candy. When there are some adult protests against this holiday, Johnny, Dukey, Susan, and Mary gain an unlikely ally against this – the Beekeeper.

After hearing about American heroes in Social Studies class, Johnny decides to help his classmates by bringing back applesauce as a vigilante after the Lunch Lady outlaws it. However, this lands him into trouble.

Johnny refuses to bathe, and his family forcibly attempts to wash him. Meanwhile, Dukey is mad because he thinks Johnny forgot his birthday.

Johnny has his sisters use an invention that will give him a mustache so that Johnny can get into a movie meant for older people. But when Bling Bling Boy pesters Johnny to use the invention on him, Johnny shoots the invention at him too much and now Eugene looks like the monster from a movie.

When Bumper uses kung fu moves to take over the school, Johnny seeks Dukey's kung fu advice, but to no avail.

Bling-Bling Boy steals Susan and Mary's shoes, and it is up to Johnny and a reluctant Dukey to retrieve them before their dinner with Gil.

Susan and Mary need to get Lolo away from Johnny and Dukey for various tests when they try to make a profit out of her in order to get a video game system.

Johnny must make a bench for woodshop class or he goes to summer school.

Doggone doggy adventures result when Susan and Mary fashion a mind-controlling obedience collar to tame Dukey's bad behavior. Then, the girls invent an acne cream.

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All Johnny and Dukey want is a simple bike race between the two of them; but everyone joins the race.

Johnny and Dukey test a perfume experiment and now everyone is attracted to them. They use this to their advantage, but it goes out of control.

Seeking revenge, Blast Ketchup sucks Hugh into the Tiny'Mon world, trying to suck Johnny in. Thinking he is one of Johnny's Tiny'Mon, he captures him. Johnny, Dukey, Susan, and Mary must stop him. To re-exit the game, they must win another battle with Blast.

When a condemned hotel gets haunted by ghosts Susan and Mary drag Johnny, Dukey and Gil into the house to prove that the ghosts are fake.

It's time for the Earth Day Carnival and the Johnny Stopping Evil Force 5 (with Zizrar replacing the Beekeeper) returns and obtains the same mutant powers as Johnny X, and Super Dukey.