A thick fog envelopes the Stardust Crusaders as they travel towards Egypt, so they seek refuge in a nearby town. Polnareff encounters Enya, a beautiful and mysterious young woman on a deadly quest of revenge.

Jotaro learns the secret of his Stand power and about his family's enemy, the vampire Dio. Later, Jotaro is attacked by Noriaki Kakyoin and his Stand Hierophant Green, an assassin controlled by Dio.

Seventeen-year-old Jotaro Kujo refuses to leave his jail cell, believing that he is possessed by an evil spirit. Jotaro's grandfather Joseph Joestar, and the mysterious Mohammed Avdol introduce him to spirit manifestations called Stands.

Polnareff is attacked by the Stand known as the Hanged Man, an enemy Stand. Polnareff is lured into a trap set by J. Geil, user of the Hanged Man and his partner, Hol Horse.

Kakyoin and Polnareff desperately seek a way to defeat the Hanged Man, who can strike out at them from within reflections while remaining invulnerable to their attacks.

The Stardust Crusaders meet a new addition to their group-a dog named Iggy who is actually the user of The Fool Stand.

Polnareff becomes a living puppet under the control of Enya and her incredible mist of death Stand Justice.

The Stardust Crusaders are pitted against another of DIO's assassins-N'Doul and his deadly water Stand, the Egyptian god Geb.

The Stardust Crusaders arrive at Dio's lair, but Dio's finest assassin, Vanilla Ice, slay Avdol before their horrified eyes. Polnareff and Iggy take on Vanilla Ice while the others go after Dio.

Kakyoin steps up to face Dio, but finds himself fatally outclassed.

The Stardust Crusaders encounter a gambler named D'Arby who claims to have information they need. They have to beat him in the ultimate wager-one where their very souls are at stake thanks to the use of his Stand Osiris.

The century-old blood feud finally comes to a close in the final battle between Jotaro and Dio.