An aspiring doctor shoots her husband in front of their two sons on the side of a Nebraska interstate; a jury must decide whether this was an abused woman defending her life or a fed-up wife who wanted out of her marriage.

A teen boy makes a shocking 911 call claiming his grandmother shot him. As detectives investigate, they uncover drugs and deep familial conflicts spanning a generational divide, leaving a jury questioning who to believe.

After best friends spend an evening Christmas shopping, the night ends with one man fatally shooting the other. The survivor claims self-defense, but his foggy memory, forensic evidence and witness accounts suggest there could be more to the story.

A former Marine is fatally shot by his neighbor in broad daylight; the shooter claims self-defense, but eyewitnesses state he was the aggressor; when investigators uncover a feud between the two, it calls both of their motivations into question.

An Army veteran kills the head of his girlfriend’s household after confronting him about sexually assaulting the young woman. After hearing a recording of the fight, investigators must decide if this was vigilante justice or self-defense.

Seventeen-year-old Anthony Templet calls 911, confessing to shooting his father in self-defense. However, with no signs of a physical attack, authorities suspect murder. As the investigation unfolds, the dark underbelly of the family is exposed.

A family is in shock when their patriarch kills his brother-in-law and claims self-defense; when police uncover a bizarre story of missing cash and betrayal among this tight-knight immigrant family, the community doesn't know what or who to believe.

Hector Campos fatally shoots neighbor Ana Weed after an argument on their property line. While Hector takes to national TV to plead self-defense, Ana's family reveals to investigators a tale of betrayal, secret spouses and a fateful escape to Mexico.

A mother of three shoots and kills her neighbor in a home invasion, leaving a small community grasping for answers. While the neighbor's parents question this apparent act of self-defense, the police find a journal that may be the key to the truth.

After suffering years of abuse, Jema Donahue, a Missouri woman, claims she had no choice but to kill her estranged husband, Javon, during a gun struggle; when the autopsy is performed on the body her mother helped her bury; however, her self-defense story comes into question.

A cosplay model makes a frantic 911 call claiming she woke up to find her boyfriend stabbed to death. Surveillance footage from around the home leads detectives to the killer, but also raises the question: Was this self-defense or murder?

Wealthy dentist Kirk Turner tells police he killed his wife, Jennifer, with a pocket knife after she impaled him with a spear. However, a closer look at the couple's turbulent life calls into question what really happened.