In the 1970s, the Boston underworld is in chaos. Dozens of Irish neighborhood gangs have spent decades brawling over turf, creating a power vacuum. But one Machiavellian foot soldier will scheme and kill his way through the ranks to become the most famous gangster in Boston history, leaving a unified Boston Irish Mob and the longest manhunt in U.S. history in his wake.

In the 1970s, the Colombian cocaine trade is wide open. Hundreds of small-time smugglers compete for control of the lucrative new racket. But a petty thief will soon rise to become the most powerful criminal in history, unleashing a bloody reign of terror to create the first global drug cartel, and become the first billionaire kingpin of the 20th century.

In 1980s New York, the American Mafia is at war with itself. Two opposing factions, old school versus new school, split the Gambino crime family down the middle. But one murderous capo will emerge as "The Boss Of Bosses" and become the face of the most influential criminal organization the world has ever seen.

In the 1990s, three violent cartels battle for control of the Mexican drug world. But one brutally ambitious Narco will rise above the rest to create one unified cartel, and become the most powerful criminal in Mexico’s history.