At the Pet Expo, the Biskits sabotage Blythe at every turn, fueling superstitions over her entry. At the end, the Pets and Blythe are able to recover her stuff and exposes the Biskits' sabotage. The Biskits' butler confesses that they made him take part of their scheme. They fired their butler. The butler became a photographer. The Biskits are humiliated and expose for their crime. Blythe won the International Pet Fashion Expo. Pets got their faces at the magazine.

When Blythe gets accepted into the junior program at a fashion school, she, along with her family and friends from school and at Littlest Pet Shop, have to bode with the anxiety of her leaving.

Blythe stresses over the upcoming International Pet Fashion Expo when she is asked to do a photo shoot for Très Blasé.

Blythe must babysit Buttercream while trying to finish reading a book simultaneously, while Pepper struggles to socialize with a visitor to the day camp whom she finds herself smitten with.

While on her way to meet with her friends at a flash mob, Blythe gets trapped in the dumbwaiter along with Zoe, Pepper and Minka. While Penny Ling tries to attract the attention of the boys to get them out from the dumbwaiter, Zoe and Pepper start to fight, and within their compact space, Minka's claustrophobia is triggered.

Roger reveals to Blythe that he has just submitted Blythe's pet backpack to Mona Autumn, a critic for the top fashion magazine, Très Blasé. Knowing that Autumn's critiques are notoriously harsh, she starts panicking about her interview, ignoring the pet's problem with a new visitor, Wiggles McSunbask (voiced by Colin Murdock), a juvenile alligator who soon takes over the day camp. When Blythe's designs are rejected by Mona, as feared, and suggests that she peruses another career, she grows depressed, much to the sadness of Roger and the helplessness of the pets.

When Blythe fills in for Zoe's owners and accompanies her to a dog show in Paris, they suddenly find themselves smitten; Blythe with the city and Zoe with a mime artist dog named Philippe.

Roger takes Blythe and the pets to a camping trip in search of Bigfoot.

On nail-clipping day at the day camp, Sunil becomes anxious about being clipped and cowers in fear in front of Blythe's friends. Jasper, who finds his worried facial expression cute, takes a picture of him with his phone and edits it into an image macro. Soon after he uploads the macro on the Internet, Sunil and the day camp attracts media coverage from across the globe. His attention becomes the source of jealousy for Zoe, and the vanity of the Biskit twins, who produce a music video of themselves in an attempt to become viral.

Blythe must trade in her scooter for a sales kiosk in order for her to enter enter the International Pet Fashion Expo. Meanwhile, Roger's airline launches a "Pet Jet" service, with the pets using it to launch one of their largest fantasies yet.

Penny Ling decides to give Sunil a superhero outfit and make the two of them a superhero duo in order to help Sunil overcome his fears. Sunil pretends to rescue his friends, which becomes a problem when he believes he actually has superpowers. Meanwhile, with the help of Russell and Sugar Sprinkles, Blythe helps Youngmee and her aunt Christie find an ideal parking space for the Sweet Delights truck, only to compete for it against the Biskit Twins.

The pets try to convince Minka that she is the first monkey to land on Mars, and Pepper asks Blythe for input for her stand-up comedy act.

After moving into an apartment, Blythe Baxter gains the ability to communicate with animals after falling in a dumbwaiter. There, she meets a group of pets who reside in a day camp area of a pet shop, who enlist her help when the store is on the verge of running out of business.

Blythe uses the pets as diversions in order to rescue Zoe's sister from inside Largest Ever Pet Shop, an expansive pet store retail chain owned by the Biskit twins' father, Fisher Biskit.

Youngmee's Aunt Christie opens a confectionery store adjacent to Littlest Pet Shop, and the pets meet pet Buttercream Sunday, a hyperactive rabbit, who invites them to overindulge themselves on the sugar-filled treats located in Christie's pantry.

When Blythe and the pets travel to Shanghai to attend a ceremony honoring Mrs. Twombly as originator of Kung Fu Quilting, Penny Ling is reunited with family she never knew she had. Meanwhile the pets prepare a Chinese dragon dance to ward off spirits.

In the second part, Blythe hosts an animal fashion show featuring the pets in order to drive revenue to the pet shop. Meanwhile, the Biskit twins Brittany and Whittany plan to stop Blythe by embarrassing her during the climax of her show.

Russell, Zoe, and Vinnie, along with Buttercream, try to retrieve a recipe stolen from Blythe by the Biskits, who plan to use it for a baking competition hosted at Blythe's school. All the while, Vinnie has a vision of cakes occupying the world.

While searching for Mrs. Twombly's missing glasses, Blythe comes across Shivers, a fast-talking squirrel with a hoarding problem. When Blythe and the pets realize Shivers is at fault for items missing from Littlest Pet Shop, they try to help him face his issue.

An endangered specimen of cobra escapes from within a pet carrier of Fisher Biskit, after finding a potential buyer for it. Meanwhile, after three straight days of rain, the pets go on a walk with Blythe to their public park. Sunil breaks away from the group, and finds himself among a group of tribal raccoons, as well as a pigeon who can understand them. There, they find the escaped cobra, and Sunil saves them after confronting it using his primal instincts. They celebrate, and the raccoons force Sunil to stay with them indefinitely as their king.

An old nemesis shows up to defeat Blythe and the pets competing in the Carnival parade in Rio.

Russell tries to reconcile Sunil and Vinnie's friendship after an emotional falling out sparks between them.

Blythe stumbles upon some keys belonging to her crush, Josh Sharp, and goes searching for him using Sunil's precognition. When he assumes she has gotten lost due to his own lack of faith in his psychic abilities, he enlists the help of his friends, along with larger-than-life parrot Esteban Banderas.

Blythe discovers Mrs. Twombly's past as the inventor of a unique martial art. Meanwhile, Pepper's comedy idol, Old Bananas, comes to visit the day camp, but finds herself struggling to amuse him with her jokes, in order to earn his signature thumbs up of approval.

Mrs. Twombly is inspired to set up a booth for a self-proclaimed pet psychic by the name of Finola, after she demonstrates her mind-reading on the pets by describing their personalities (while getting them entirely wrong). However, her predictions for other customer's pets break the bank for Mrs. Twombly; all her prognoses revolve around the pet wanting a brand of dog food. Meanwhile, the pets suffer while trying to mold themselves into Finola's personality readings, trying to avoid disrupting her partnership with Mrs. Twombly. When Blythe sees what is happening, Finola's pet sugar glider, Sweet Cheeks, may have the answer for Blythe as to what his owner's business really is.