Things are looking pretty final as monsters appear all over the world and overwhelm all the Center agents while the now evil MOM and the Gatekeeper unite to destroy Martin, Diana, Java and Billy. Is this the end of the line for the gang and the Center?

While sick with a mystery illness Martin, Java & Diana are quarantined in the Center's medical wing and reminisce about their past adventures. Due to a misunderstanding they think MOM has decided to terminate them before they can spread the sickness and flee deeper into the Center unaware that the real cause of the alarm is that the Boogeyman has escaped and they're heading right for him!

After an incident at the school library Martin claims Diana is a \"goody two-shoes\". So she drastically changes her image in order to prove that she can be a bad girl when she wants. At the Center Mom tells them that there was a bizarre attack on the mayor or Stillwater, Louisiana by an invisible force and sends them to investigate. After a few more weird events they discover that a corrupt politician is using Voodoo Dolls to eliminate his competition. He intends to win the mayoral race and end up in the mayor's office. An office that was built to conceal an evil Shaman's lair. Once he harnesses the power of an ancient artifact hidden below he will become an unstoppable voodoo priest!

Martin and the gang are off to France to check out the mysterious disappearance of two teens on a boat ride. When they learn that one of the missing teens works at a surf shop, they head there to check it out, and find a vampire who is sucking the souls out of people. She captures Martin, who is revealed to be the descendant of her husband, and forces Diana, Billy, and Java to go and rescue him before the vampires can unleash their brethren from the Banished Realm.

Looking for two missing Center agents strands the gang in the long lost underground city of Alpha-Omega. The Alpha-Omegans mistake the bald headed Diana for their missing Queen and the sign they've been waiting for to begin their conquest of the surface world.

While Marvin has left Torrington, Martin is irked that everyone "particularly Jenny" is still talking about him rather than paying attention to his extreme sports stunts. So his jealousy kicks into overdrive when he discovers that M.O.M. has made Marvin a Center agent and assigned him to work with Martin and Diana on their latest mission to investigate odd incidents at the Scopes Institute "a school for the blind", located in British Columbia. With Marvin out to flaunt his superiority, Martin seething with jealousy, and Diana drooling over Marvin, is anyone on the team focused enough to figure out what is really going on before the banished sorcerers called the Seers succeed in returning to spread chaos across the Earth?

Martin, Diana & Java are sent to a Caribbean resort where people have gone missing. They find that the resort is actually run by shapeshifting zombies who are sacrificing the vacationers to a sea creature called Hexan.

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Martin, Diana, and Java investigate a small western town in Utah whose entire population seems to have disappeared overnight. Suddenly, the people return to the town, but they all seem a little different.

People living in New Mexico near the Los Lunas nuclear power plant wake up w/ missing hair and teeth, and also seem to be appearing in two places at once. When Martin, Diana, and Java arrive to investigate, they find some evidence of alien involvement that freaks Billy out and forces him to reveal his hidden past as Ganthar, the leader of a gang of extraterrestrial pirates.

At a Sydney, Australia museum, a robber is surrounded by a mysterious green mist. The group is sent to investigate. They discover that they were up against a genie who wanted to cause chaos all over the world. Java and Diana are rendered helpless by the genie's power. Can Martin stop the genie before it's too late?

Martin's attempts at filming his own horror movie are interrupted when a giant ant emerges from the screen of the local Drive-In which is showing an old sci-fi movie about giant insects. Martin and Diana soon discover a 500 year curse is bringing imaginary monsters to life and since Java was playing the creature in Martin's movie he's been transformed into a real radioactive swamp zombie. To make matters worse if the monsters aren't all defeated by sunrise they'll become indestructible and Torrington will never be rid of them.

M.O.M. reveals Billy's hidden life as Ganthar, destroyer of worlds, before he abandoned his old name, form, and way of life and joined the Center. She sends the gang to trade the captured aliens for Billy, unaware that once the aliens reunite, they will be able to call in reinforcements and destroy the Earth! The only one who can stop them is Billy, but to do that he will have to become Ganthar again— and he might not want to change back.

When M.O.M. ceases to return from her Jamaican vacation, Billy calls in Martin, Diana & Java to investigate. They uncover what M.O.M. was really up to – she was on a secret mission to unlock the Gateway.