Masters and Johnson are interviewed as they take on an exotic new patient.

Masters continues his surrogacy program, now under Johnson's critical eye.

Masters and Johnson look to capitalize on their burgeoning fame.

Masters looks to groom Art as his protege in a new area of research as Johnson does her best to keep Nancy at arm's length. Betty seeks an unlikely source for assistance in her fight for equal rights to Helen's baby.

Masters takes on a high profile patient. Virginia and Libby come to terms.

Johnson jets away with Dan Logan. Masters begins his surrogacy program.

On the heels of Masters’ proposal that they participate in the sexual response study, Johnson considers the best course of action to keep her job – only to find she no longer has one. The study has been forced out of the hospital and Masters believes Johnson is to blame. As Johnson fights to save her job and struggles to care for her kids, Masters moves his study to a brothel. But Masters soon discovers that the chaos of the cathouse is unmanageable without Johnson’s help.

Masters privately treats a couple for infertility, without revealing his relationship to them. Johnson realizes her work with Masters can be used to help people suffering from sexual dysfunction - but quickly gets in over her head when she attempts to treat Barbara Sanderson on her own. Libby is unnerved after witnessing a hate crime that is then whitewashed by the police.

Masters seeks unexpected advice. Virginia is distracted by news of Henry.

Masters and Johnson take on a famous couple hoping to renew their sex life.

Johnson objects to Masters' program following missteps in the protocol.

In the wake of their fallout, Masters and Johnson search for purpose in a world without one another and look to work as their personal lives crash down around them. Libby finds herself alone for the first time since her marriage and discovers some unexpected allies. Season premiere.

Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Given their fractured triangle, Libby reevaluates her relationship with Bill and Virginia.

Masters and Johnson adjust to new partners, but their respective cases have them second-guessing the instinct to remain separated. A romantic prospect pushes Libby to embrace life as a newly single woman of the sexual revolution.

Masters begins a new job at Memorial Hospital under Betty's extortion terms only to discover that his boss insists he leave Virginia behind in favor of a handpicked secretary. Meanwhile, Johnson is torn between pressing Masters to rehire her and staying by DePaul's side as her condition worsens.

Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram that changes her perspective.

Masters and Johnson continue their research in the brothel but skewed data confirms that Masters must get the study back into the hospital. At the hospital, Johnson is surprised to learn that a distinguished new doctor on the OB/GYN floor is a woman who has no interest in female solidarity. Meanwhile, Libby struggles to conceive and Dr. Ethan Haas gets the case of a lifetime – a woman pregnant with quadruplets.

Masters deals with the ramifications of his disastrous presentation and being fired from the hospital. Meanwhile, Libby urges Masters to get another job; and Virginia fights off advances and innuendos stemming from the belief that she was the woman in Master's explicit film.

Langham observes Masters and Johnson exiting a hotel room and shares his suspicions with DePaul, who is forced to make plans for her work without Virginia's involvement. Meanwhile, Betty attempts to conceal her infertility from Gene; and Masters tries to bring Johnson aboard as his assistant only to be thwarted by the head of the hospital, who takes a prurient interest in Masters' study.

In the wake of Masters' discovery that Johnson has continued to have romantic relationships with other men, he becomes impotent without her knowledge and cuts off their sexual work together. He tries to keep his new clinic solvent over the course of three years by borrowing against his house, offering medical services to the hotel - and finally accepting money from his mother.

Virginia continues to impersonate a patient's case history in order to glean advice from a psychiatrist. Betty and Masters' attempt to remedy Lester's impotence by hiring a prostitute rattles him even further. Libby gets the third degree when she offers her eyewitness testimony regarding the beaten man. And Barbara Sanders wrestles with an unsettling diagnosis that exposes a chain of secrets and causes Masters and Johnson to clash over their treatment strategy.

Masters and Johnson face the press for the first time.

Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic. As everyone in their lives either moves on or falls away, Bill and Virginia find solace in one another. Season finale.

Dr. William Masters, Washington University’s foremost OB/GYN, runs a successful medical practice by day and conducts a secret study of human sexuality by night. Former nightclub singer Virginia Johnson joins the hospital secretarial staff and proves herself to be an asset to Masters’ work.

With the study back in the hospital, Masters and Johnson recruit new participants on campus. But Johnson is shocked when her ex-husband George, who’s crashing on her couch, wants to sign up. Masters’ mother comes to visit, but her new take on life stirs up painful memories of his childhood. And Libby’s attempt at playing matchmaker with Virginia and Ethan doesn’t go as smoothly as she’d hoped.