When Allison becomes a lawyer and Joe starts a new job, the Dubois family is forever changed on the series finale of Medium.

On the 100th episode of Medium, an infant is kidnapped and Allison investigates the disappearance. But when she becomes too obsessed with the infant, Joe starts to get worried about her. Meanwhile, Bridgette and Joe are surprised after Marie manages to play the clarinet without any issues even though she hasn't attended any classes, while Bridgette is struggling to play.

A series of mysterious fire-related deaths may be tied to Allison's dreams of a blaze. Allison must also think about where her professional career is headed, as Devalos starts thinking seriously about running for mayor.

After a neighbor is murdered, Allison's fears for her own family prompt her to install a high-tech talking burglar alarm, which she later suspects may be communicating with Marie. Also, Ariel meets a ghost who could help her get into the college of her choice.

When an animal rights activist working undercover at a farm goes missing, Allison befriends a pig that could hold the key to the woman's whereabouts. Also, Joe's special birthday gift from Marie leaves him wondering how she was able to obtain it.

When Allison gets a skin graft on her hand after a burn, she is puzzled when the same hand acts with a mind of its own, gesturing uncontrollably. Also, Bridgette keeps her real role on the soccer team a secret from her parents.

Allison helps with the location of a missing child. Afterwards she gets a vision about the child's future and is not sure anymore what she should do to help the child.

The psychic killer from "S.O.S." escapes from prison, where Allison helped put him, and goes after Allison in her own house.

Devalos tries to reclaim the D.A.'s office. Allison's support of Devalos is tested when she has visions of Senator Jed Garrity, Devalos' strongest political supporter, involved in a horrible conspiracy.

Delavos receives help from Allison when he investigates the murder of his friends sister. But the case is taken into an unexpected direction when when Allison's visions involves the friend's former husband and current spouse. On the domestic front, Bridgette finds herself in trouble at school when she is caught drawing pictures of her teacher in the nude.

Allison investigates when a brother and sister report the disappearance of their mother. Meanwhile, Joe's sister moves in with Joe and Allison after walking out on her husband Ryan, but Joe's father has advice from beyond the grave about her relationship.

While investigating a rash of murders, Allison sees floating symbols above people's heads, signs that she thinks could match them with their perfect mate. Also, Joe is put in a tough situation when one of his employees accuses another of sexual harassment.

When Allison begins having flashes to a specific time in the future, her sense of dread grows as she feels more and more powerless to stop a catastrophic event from occurring.

Suddenly unable to understand the spoken word, Allison's marriage shows signs of strain and she develops an unexpected friendship with a linguist. Unable to communicate with his wife, Joe reaches the limits of his patience being married to a woman who is a slave to her visions.

Allison's dreams question her brother's recent good fortune; the Devalos campaign sees Bridgette as an asset.

Allisons helps the District Attorney trying to find a missing brother of a close friend. She becomes paranoid about antiterrorist agents from the government. Joe gets uneasy when he suspects that Bridget might be communicating with a dead author.

Three girls are found murdered. Allison's visions connect Det. Scanlon with the case.

Allison dreams about a strange friendship between two recently murdered ghosts. When she tries to help one of the ghosts solve his murder, she is surprised when he declines her help.

Arliss Howard reprises his role as Texas Ranger Kenneth Push, who returns to Allison's life when he experiences unnerving visions about a Phoenix-based slaying. Meanwhile, Joe tells a little white lie---and suffers the consequences.

Allison is confused when her dreams of a man murdering his wife keep occurring, even after she helped Devalos convince the jury of the suspected killer's guilt. Through her troubles she manages to make a new friend named Debra. Meanwhile, Joe is frustrated by the therapy sessions that his job enrolled him in, and can't express his feelings to Allison because the recent hostage situation he was in is still greatly affecting him.

Larry Watt, a defense attorney who has caused trouble in Allison's past, asks Allison to be a consultant for him. Low on money, Allison accepts his offer. She later has a dream that his client murdered his wife.

Allison has visions of a friend of Scanlon and Lynn DiNovi dying in a home mishap. This causes her to struggle with connecting some recent "accidental" deaths, consequently putting her own health in jeopardy.

Allison meets Meghan Doyle, Joe's new business partner. Meanwhile, her old car stops working and Joe surprises her with a nice looking used car. The car ends up being the center of a horrible unsolved crime though.

Allison has dreams that help Scanlon in his search to find out who killed a wealthy local drug dealer. Allison and Scanlon are dumbfounded when Allison's dreams lead them to a severely impaired man with a bullet stuck in his brain. Meanwhile, Joe's partnership with Meghan Doyle is put in jeopardy.

When Ariel acts strangely, Allison becomes worried that her daughter might be possessed with the spirit of a murdered stripper who wants revenge on her killer.