Emma tries to help her drug addicted sister and learns that local addicts are exhibiting strange mutations linked to tainted heroin.

In Manhattan, Frank Black and an anthropologist link a bizarre, ritualistic slaying to a lost tribe of Native Americans who follow apocalyptic prophecies.

A fundamentalist Jewish sect abducts a pregnant woman hoping to raise a pure child for the priesthood and force the coming of the Messiah.

Emma and Frank investigate the mysterious biological research conducted by a former Millennium Group member who is dying from a mysterious disease.

Catherine and Lara investigate when five girls claim they saw a vision of the Virgin Mary.

Frank aids in the search for a man who is supposedly carrying a highly contagious virus and discovers the secret behind the Human Genome Project.

Frank and Emma investigate murders on the set of a movie based on one of Frank's former cases.

In the Brighton Beach area of New York City, a man named Yaponchik kills a Russian Elder by shooting him in the face with a 12 gauge pistol. It becomes the third such killing in which the perpetrator mutilated the body to prevent positive identification. Frank assists N.Y.P.D. Lieutenant McCormick, Yura Surova, from the Moscow Police Department, and undercover officer Andrei Medikov with the investigation. While inspecting the Elder's corpse, Frank notices an odd mark in the shape of a inverted "V." But he is unable, at first, to determine its meaning.

A mysterious Asian woman is linked to several strange deaths aboard a ship.

The Marburg virus has apparently run its course. Several months after the death of his wife and a nervous breakdown, Frank rejoins the FBI and investigates a plane crash with a new partner.

Frank and Emma investigate a family of identical women who are apparently being killed off.

Frank and Emma investigate a survivalist group worried about the Y2K bug.

Frank and Emma investigate the suicide of a former FBI agent and discover links between the FBI, the Millennium Group, and the Los Alamos nuclear research center.

Near the University of Colorado at Boulder, a group of college-age students gather at a warehouse/techno night club. Art Nesbitt, a pharmacist, approaches a couple, Mel and Leslie. He opens his palm, revealing two capsules. Under the influence of the powerful drugs, the couple accompany Nesbitt to a small room. Nesbitt captures their lovemaking on videotape, then injects them with a lethal poison.

Frank searches for a female serial killer and her lover after the pair escape from prison.

A desperate man sets out on a killing spree taking revenge on the holy men that he believes have led him to stray. Frank can see the man's sense of faith and the lack his faith could be the key to stopping this killer. Frank then puts himself in danger when he walks into a hostage situation at a small town church.

Emma is haunted by memories of the death of her sister while she and Frank hunt a spree killer.

On Christmas, Frank and Jordan go one vacation in Vermont. Unexpectedly, they get involved with a supposedly dead Mafia hit man who appears to be living in the woods with a number of mysterious women.

A man, Cutter, parks his automobile near a home with a "For Sale" sign on the front lawn. After speaking briefly with a realtor, Cutter signs his name in a guest book and makes his way through the house, where he takes particular interest in a little girl's bedroom. Later that evening, the owners return home and tuck their young daughter, Patricia, into bed. Later that night, Patricia suddenly begins screaming.

Maddie Haskel, twenty-years-old and heartland pretty, attends her mother's funeral in Joplan, Missouri. After the service, Maddie returns to her family's home, where she is approached by a vicious-looking man named Jim Gilroy. Gilroy's attempt to rape Maddie comes to a sudden halt when Maddie's boyfriend, Bobby Webber, emerges from the shadows wielding a length of iron pipe. After Gilroy is knocked unconscious, Bobby and Maddie drive off into the night with their prisoner safely tucked away in the trunk of their automobile. A Missouri State Trooper notices the vehicle has a burned-out tail light and orders Bobby to pull over. When the trooper hears noises emanating from the trunk, Bobby grabs a .357 and shoots and kills the trooper.

Peter Watts tells Catherine that Frank missed a routine homicide review with Yakima police that morning. Fearing the worst, Peter and Catherine access Frank's computer, looking for clues that would shed light on his disappearance. The pair uncover email correspondence between Frank (using the pseudonym "David Marx") and a Doctor Daniel Miller. Catherine tells Peter that five years ago, just before Frank collapsed, he would sometimes vanish for days at a time and check into hotels using the same pseudonym.

In North Dakota, a woman named Sally Dumont rides a horse to her farm. As Sally guides the animal to a stall in the stable, she discovers another horse, its coat stained with blood, lying on the ground inside its pen. As she kneels down next to it to investigate, Sally notices someone wearing a pair of rubber boots standing in the adjoining stall. Terrified, she makes her way to a phone and calls for help. Suddenly, the intruder looms up from behind and knocks Sally unconscious.

As Frank's marriage begins to crumble, a pack of vicious dogs terrorises a small town, and as Frank investigates he discovers several truths about the Millennium Group.

Frank and Emma investigate a number of apparent drownings that occurred on dry land.

Against the initial resistance of the Group, Frank travels to Portland, Oregon, to investigate a murder at an animal shelter. He meets with Jim Horn, a profiler and candidate for the Millennium Group. But Horn is distracted by his imminent divorce, and there is tension between him and Frank. When the killer strikes again, Horn is losing control, and Frank not only has to catch the killer who leaves grisly messages on his victims, but he has to contend with Horn as well who is more than ready to stop the murderer with terminal prejudice.