After listening to Trudy's last message, Monk finally discovers who killed his wife. Racing against time before he dies of poison, he must make a fateful decision.

Monk is called to a murder at the location where he first heard of his wife's murder, and while Monk figures out who the assassin is, he doesn't know that the one who ordered the hit is also responsible for the death of Trudy. Knowing that Monk will eventually put all the pieces together, he orders Monk's death, and when all hope seems lost, Monk discovers something which could finally end his 12-year nightmare.

After twenty-two-month-old Tommy Graser finds a severed finger and gives it to a policeman, Monk walks through the park with Tommy trying to retrace the child's steps. He finds no body or other incriminating evidence, but he does discover a surprising affection for the placid and intelligent toddler, who constantly repeats Monk's name and quietly submits to having his hands wiped when he touches ""nature."" A lab technician identifies the finger as that of a twenty-five-year-old man, and Monk deduces from a callus that the young man played the violin. After visiting the home of Daniel Carlyle, a musician who fits this description, Monk concludes that Daniel's mother and her other son, Jason, killed Daniel and that Jason is masquerading as his brother. Meanwhile, little Tommy is temporarily removed from the custody of his foster parents, and Monk surprises everyone, including himself, by volunteering to care for him for two weeks until his new adoptive parents can take him. With Tommy in

Mr. Monk takes a walk when he can't sleep, but ends up running into a murder.

Monk is summoned to jury duty against his wishes and must solve two crimes: he has to convince the jury the defendent is not guilty, and solve the mystery of a corpse outside the jury room's window.

When Monk's older brother Ambrose calls him about a ""life-or-death matter,"" Monk accepts the call grudgingly and agrees to meet the brother from whom he's been estranged since Ambrose refused to attend Trudy's funeral seven years before. In fact, Ambrose, an agoraphobic packrat whose house is full of bundled up newspapers, has not left the home he and Adrian grew up in for thirty-two years. Believing Ambrose's claim that his next-door neighbor, Pat Van Ranken, has murdered his wife after a loud argument, Monk and Sharona visit Van Ranken and decide to follow him. Van Ranken, meanwhile, is behaving very strangely, entering a potato sack race and a bingo tournament in which the prizes include a cherry pie. It's not hard for the Monk brothers to tie Van Ranken to another murder involving a cherry pie--the challenge is finding a motive for Van Ranken and proving that he did it. The episode provides a glimpse of Monk's family background and the reasons for his estrangement from his brother,

Monk is arrested for murder, and finds that he has to go on the lam to clear himself.

Monk is reunited with his agoraphobic brother, Ambrose, after the murder of an armored car driver.

Monk finds himself adrift in an ocean of filth when a garbage strike brings San Francisco to a halt...and Adrian to near-paralysis.

Stottlemeyer must keep up the pretense that Monk is dead, while Adrian tries to determine who framed him for murder.

When Sharona returns to San Francisco to handle legal issues related to an uncle's death, Monk suspects foul play and is torn between the differing styles of Sharona and Natalie.

Monk reluctantly adopts a dog while looking into the suspicious disappearance of its owner.

With Sharona in New Jersey to visit her ailing mother, Monk is left in the very incompetent hands of his annoying upstairs neighbor, Kevin Dorfman, but the prospect of a week with Kevin is eased somewhat by a visit from Trudy's father, Dwight Ellison. Dwight invites Monk (and Kevin) to spend the week with him and his wife, Marcia – and at the same time investigate gameshow host Roddy Lankman, who appears to be involved in a conspiracy to allow one of his contestants, Val Birch, to win every game. Despite the memories of Trudy aroused by spending time with her parents in her former home and the questionable help of Kevin, Monk discovers evidence that Lankman visited Birch's house – and that Birch visited the site of the accident that killed Lankman's assistant, Lizzie Talvo. To discover exactly how Lankman and his crooked contestant are communicating – and possibly prove that they're involved in something much worse than cheating – Monk becomes a contestant on the game show. His knowledge o

When monk's favorite singer, Willie Nelson, is suspected of murdering his tour manager, Monk steps in to clear his name.

With Sharona in New Jersey remarried to her ex-husband, Monk has been without an assistant for three months and it's time to find a new one--if only he could find a suitable applicant. When Natalie Teeger, a thirty-something widow with an eleven-year-old daughter, arrives at his house, he thinks she's applying for the job, but she's really been sent by Captain Stottlemeyer to get Monk's help--two men have broken into her apartment in the last few days and she had to kill the second one with scissors in self-defense. Examining Natalie's apartment, Monk finds a single clue, an unused fish net caught between the sofa cushions, suggesting that the intruders were trying to steal Mr. Henry, Julie's pet fish. But why would anyone want to steal a ninety-nine-cent red herring, er, crimson marblefish? A second clue surfaces when Lieutenant Disher finds a note in the dead perp's pocket reading ""2:30 Sea of Tranquility"" and Natalie identifies the Sea of Tranquility as an exhibit at the science mus

While working on a double murder, Monk finds that imitation is the sincerest form of flattery when he finds that an obsessive method actor has been cast to play...Adrian Monk in a new movie.

When Dr. Kroger retires after his cleaning lady is killed, it's up to Monk to solve the case and get Dr. Kroger back to work.

Monk meets a visiting African widower who's determined to find the hit-and-run-driver who killed his wife near Monk's apartment. Monk begins to identify with the man and confuses his wife with Trudy.

Natalie tries to throw a surprise party for her surprise-hating boss, who is busy trying to solve the murder of a maintenance man.

Upon being reinstated, Monk is put in charge of tracking down a serial killer.

A former San Francisco police detective suffering from an extreme case of obsessive-compulsive disorder is called in to investigate an apparent assassination attempt of a mayoral candidate in which one of his bodyguards is killed.

Monk suspects that the man responsible for the mail bombing murder of rich and beautiful Amanda Babbage is the victim's brother, Brian – who has been in a coma for four months after attempting to lure Stottlemeyer and Disher into a car chase and crashing into two cars. Since the package was postmarked three days before the bombing, Stottlemeyer is naturally skeptical, but he prefers siding with Monk to tagging along behind Agent Grooms of the Bureau of Alcohol, Tobacco, and Firearms, who suspects the victim's other brother, Ricky.

Who would murder a death-row inmate forty-five minutes before his execution--and why? That's the question Captain Stottlemeyer asks Monk--but Monk's response is to ask why it matters. As Monk is hurrying to leave the prison, however, he gets a phone call from his old nemesis, Dale ""the Whale"" Biederbeck, that changes his plans. The police consider Dale a suspect in the inmate's murder (the young man owed him twelve hundred dollars) and refuse to give him a window in his cell until his name is cleared, so Dale strikes a bargain with Monk--solve the case and he'll provide information about Trudy's murder. After interviewing the cook who prepared the dead inmate's last meal, Monk notices that another cook never clocked out the evening before. The missing cook is found dead in a freezer with a wad of bills in his apron pocket--clearly the person who bribed him to poison the inmate was afraid he would talk and killed him, too. On his way out of the prison, he receives another phone call, th

When Edna Coruthers, a model employee at a giant chain store called Mega-Mart, is killed by a falling television set, Monk is called in to investigate by the store's security chief--who turns out to be his disgraced ex-partner, Joe Christie. Neither Monk nor Stottlemeyer wants to work with Christie, whom they hold responsible for some missing cocaine and the death of two police officers, and both of them disregard the evidence that Edna might have been murdered--a broken shoe heel (suggesting that the victim ran from someone or something), her dust allergy (which normally kept her from entering the loading dock where the death occurred), and the three letters (in different handwriting but with similar stamps) complaining about the victim. Twenty-seven days later, realizing that the stamps were all from the same roll and therefore from the same person, Monk reluctantly agrees to help Christie discover a suspect and a motive by working undercover as a store clerk. But he still doesn't tr

In the middle of the night, Monk receives a phone call from a drunken Stottlemeyer, who has gone to Las Vegas with Disher for a fellow officer's bachelor party. Stottlemeyer believes that a wealthy casino owner has murdered his wife, but he needs Monk's help to prove that the death wasn't an accident. Unfortunately, when Monk arrives in Vegas with Natalie the next morning, Stottlemeyer can't remember anything that happened the previous night--including how his pants happened to be thrown out the window. As Monk and Natalie explore the elevator where the woman died, interrogate witnesses, and reenact the death scene (with Monk in the role of victim), Stottlemeyer tries to retrace his steps and deal with Disher, who has become addicted to blackjack and fallen hopelessly deep into debt. When Monk, at Stottlemeyer's insistence, takes Disher's place at the blackjack table to win back his money, he figures out how the murder occurred as he simultaneously places winning bets, but the casino o