Mr. Monk takes a walk when he can't sleep, but ends up running into a murder.

Monk is arrested for murder, and finds that he has to go on the lam to clear himself.

After listening to Trudy's last message, Monk finally discovers who killed his wife. Racing against time before he dies of poison, he must make a fateful decision.

Stottlemeyer must keep up the pretense that Monk is dead, while Adrian tries to determine who framed him for murder.

When monk's favorite singer, Willie Nelson, is suspected of murdering his tour manager, Monk steps in to clear his name.

A former San Francisco police detective suffering from an extreme case of obsessive-compulsive disorder is called in to investigate an apparent assassination attempt of a mayoral candidate in which one of his bodyguards is killed.

Monk's friendship with Captain Stottlemeyer is put to the test when Monk suspects the captain's girlfriend of murder.

One of Monk's treasured possessions is stolen from a safety deposit box, and he'll go to any length to solve the case.

As Monk and his friends watch a TV news magazine piece on the solution of his hundredth case, he realizes that one of the victims was murdered by a different killer.

When Marci Maven is accused of a bizarre crime, she turns to the object of her obsession for help - Adrian Monk.

Monk must match wits against a grandmaster chess player that he suspects of murder.

When billionaire software magnate Sidney Teal is shot dead by ex-cop Archie Modine after allegedly turning mugger and another policeman mysteriously flees the scene, Stottlemeyer calls in Monk to investigate. Meanwhile, Sharona threatens to quit (this time for sure) when her paycheck bounces, and Stottlemeyer is hounded by reporters demanding information on "Fraidy Cop."

A woman is murdered during the San Francisco marathon and Monk suspects her married lover. But he was running the race, and his tracking chip says he never left.

When Monk's older brother Ambrose calls him about a ""life-or-death matter,"" Monk accepts the call grudgingly and agrees to meet the brother from whom he's been estranged since Ambrose refused to attend Trudy's funeral seven years before. In fact, Ambrose, an agoraphobic packrat whose house is full of bundled up newspapers, has not left the home he and Adrian grew up in for thirty-two years. Believing Ambrose's claim that his next-door neighbor, Pat Van Ranken, has murdered his wife after a loud argument, Monk and Sharona visit Van Ranken and decide to follow him. Van Ranken, meanwhile, is behaving very strangely, entering a potato sack race and a bingo tournament in which the prizes include a cherry pie. It's not hard for the Monk brothers to tie Van Ranken to another murder involving a cherry pie--the challenge is finding a motive for Van Ranken and proving that he did it. The episode provides a glimpse of Monk's family background and the reasons for his estrangement from his brother,

Monk searches for a killer who is apparently targeting women with the name Julie, a name which Natalie's daughter shares.

When a friend of Monk's is killed, Monk believes that a magician is responsible and a battle of wits and sleight-of-hand ensue.

Monk joins a cult to solve a murder case, but becomes entranced by the cult's charismatic leader.

Monk becomes involved in the disappearance of a city official that could have ramifications concerning Trudy's murder.

When Sharona returns to San Francisco to handle legal issues related to an uncle's death, Monk suspects foul play and is torn between the differing styles of Sharona and Natalie.

A police officer and friend of Stottlemeyer is framed for a crime he didn't commit involving a ferris wheel. Meanwhile Monk tries to convince Stottlemeyer to get him reinstated.

Renowned philanthropist Henry Rutherford is killed when a minor earthquake rocks the city and sends a display case falling on top of him. But when Monk examines the scene, he finds clues that suggest foul play.

Monk's first flight proves to be harder than he anticipated when he begins to suspect that a fellow passenger murdered his wife.

After visiting the set of the hit TV series Crime Lab S.F. during a celebration of its one hundredth episode, Monk suspects the show's star, Brad Terry, of murdering his ex-wife so he won't have to share his huge new paychecks with her. But the actor's alibi seems solid--he was with photographers when the victim's screams were heard. To complicate matters, a fan confesses to the crime and Terry passes a lie detector test. After Terry invites the captain, Disher, and Sharona--but not Monk--to a party, Monk realizes that Terry reminds him of a popular boy who treated him the same way in sixth grade and begins to doubt his own instincts. But when Stottlemeyer invites Monk to hear Marci's confession, Monk's doubts shift to Marci's story. When she tells him that Terry's ex-wife was once an actress who made a single B movie, Monk has the clue he needs to solve the crime.

Monk tries to prove a sports agent is guilty of murder while helping Natalie’s teenage daughter with her love life.

While investigating a murder at a museum of oddities, Monk befriends a warm older woman, but he has trouble believing the friendship comes without a catch.