Suspecting foul play in Robert's 'accidental' death fall, Dr. Reichwen makes some discoveries in his investigations. But as he later realizes, his investigations may have put him in harms way.

Bonaparta attempts to shoot Johan dead, but is gunned down by Roberto, who dies of his own injuries soon afterwards. With the massacre now over, authorities rush into the town and attempt to determine what happened. Just as an officer is about to arrest Dr. Tenma, an ambulance worker arrives asking for Tenma's assistance.

Schubert, with the help of Reichwein, re-explores his past with Karl Neumann's real mother and realizes his link to Johan. As news of Tenma's arrest spreads, various people react with shock and horror, with the exception of Eva Heinemann, who is insistent that Tenma pay dearly for rejecting her. Suk tries to leave the hospital he is in to try to help Tenma, but is stopped by the Prague Police who inform him that Grimmer has sent a note to them exonerating Suk from any involvement of the deaths of the police officers. Runge also gets news of the arrest as well, but he is more interested in the Mansion of Red Roses, where he obtains a letter possibly addressed to the twins' mother. Tenma is deported back to Dusseldorf.

Robert delves into Johan's past and makes a shocking discovery. Dr. Gillen speaks to Peter Jurgens, a serial murderer about Johan's possible involvement and gets a tragic reply. Johan confronts Robert about Stephen Joos. And Dr. Reichwen receives tragic news from the police.

Grimmer and Tenma tries to stop Johan from subjecting Milo, one of the orphans, to one of the most cruel fate.

Dieter learns of a life threatening game that children are playing. Mr. Schuwald decides to donate his whole book collection to the Munich University Library under the suggestion of Karl and Johan.

Martin’s attempt to save Eva costs him his life, his last minutes with Tenma reveals a terrible secrets about Martin’s boss, Peter Chapek and the about the experiments.

Lunge and Grimmer conclude something terrible is happening in Ruhenheim when random gunshots ring out, people are either murdered or disappearing, and any links out of town is flooded by torrential rain. As Nina recovers in a nearby hospital, Tenma, using a lead from Capek, travels to Prague and meets with Lipsky and determines that Johan is in Ruhenheim.

Dr. Tenma learns about Suk's fugitive status from a journalist. And sets out to find him. Meanwhile, Suk and Grimmer goes into hiding, but is quickly found, surrounded and attacked by the STB. The STB's assault comes to a bloody end.

As time passes, more people in Ruhenheim are being shot dead by mysterious people and each other. Both Grimmer and Lunge determine that the owner of a local hotel is Klaus Poppe, also known as Franz Bonaparta. After subduing a man who was giving weapons to everyone in the town, they obtain information that one of the ringleaders is in a second hotel.

Richard re-investigates his old homicide cases and makes a frightening discovery.

Lunge tries to get into Dr. Tenma's mind by pretending to be him. Dr. Gillen learns something about Johan during an interview with a psychotic killer. Dr. Reichwen tries to warn the Lieberts of Johan's true nature. Dr. Tenma scouts for a perfect sniping location.

Lunge, from the BKA, learns that Johan may indeed exist. Nina goes into regressive hypnosis to learn more about the picture book and her past. Mr. Schuwald has a message for Dr. Tenma and sends Karl to Dresden to pass it to him.

Grimmer has the key that Petrov gave him, and a former Czechoslovakian secret police organization wants it. Caught and tortured, Grimmer tells his abductors about 'the Magnificent Steiner'.

Suk is put under surveillance by the new commissioner. Together with Grimmer, Suk retrieves the tape and research papers from the deposit box. But their movements is watched by various sides.

Nina's experience in Prague is a nightmare for her. Tenma and Grimmer meets with a top man in the Czechoslovakian STB. They are offered a deal which Grimmer refuses to accept.

Lunge investigates the secret behind the Red Rose Mansion. Tenma and Grimmer separate, but Tenma finds himself in trouble.

Former patients of Eisler Memorial Hospital enlist the aid of Alfred Baul, a lawyer, to represent Tenma. Baul in turn asks for the assistance of Fritz Vardemann. Vardemann visits Tenma in prison, and agrees to take on the defense, but is then called to the hospital when his wife goes into labor with their first child. When Baul visits Tenma in prison, Tenma is shocked to see that Baul is Roberto. Roberto then says that Eva Heinemann will be his next target.

Tenma and Milch are on the run with the injured Gustav and Helene. Eva finds her life in danger when she discovers that the attorney she's supposed to meet, Mr.Baul, is none other than Roberto.

Nina and Dieter enters the Red Rose Mansion, but Nina faints from her disturbing experience. And they end up in the care of a puppeteer name Lipsky.

Capek reveals to Nina that her and her twin brother Johan are the products of a eugenics experiment designed to breed "the perfect children". Tenma has wounded Christof and is driving him and Eva to the hospital while demanding answers on Petr Capek. While Eva makes a phone call at a payphone, Tenma sneaks away.

Nina confronts Johan who presents her with a story on what happened when many people were poisoned at the Mansion of Red Roses. Nina realizes that she was the one who witnessed these deaths, the shock of this revelation nearly drives her to suicide, but she is saved by Tenma. Capek is gunned down by members of his organization when they find out about the guard that Capek killed.

With a postcard obtained by Lipsky, Lunge arrives in Ruhenheim. There he meets up with Grimmer, whose research has led him to this town as well. A working-class couple in this town realize they win the lottery and fearing that everyone else wants to kill them, the husband buys an arsenal of weapons.

It has been some time since the tragic blood battle, and everyone is working hard to put their lives back to normal. Tenma finally locates a woman he has been searching for, and she reveals some startling information.

Dr. Tenma and Dr. Reichwen finally meet. Dr. Reichwen intends to proof Dr. Tenma's innocence in the homicides, but Dr. Tenma has other ideas.