The brothers try their hand as streamers after being chastised by their parents for not having jobs. Later, Iyami uses an experimental detergent to keep his suit clean, but after being confused by the Matsunos as an expensive liquor, is revealed to turn anything invisible (up to a point).

The prehistoric sextuplets return, partaking in dangerous sports. Later, in modern day, noticing their father acting strangely, the brothers discover that he is worried that there's not enough spark in his marriage. Feeling he should return to a more innocent time, the boys give their old man a masterclass in being a virgin, albeit with no success. After embarrassing himself in front of his sons, Matsuzou considers a love potion from Dekapan, but is this really the best way to patch things up with the love of his life?

A series of summer-themed skits. Jyushimatsu takes part in radio exercises, Iyami and Chibita try to beat the heat, Todomatsu keeps finding himself exiled by his brothers, Karamatsu tries to inject summer into everyone's lives, and the sextuplets attempt to talk to girls on the beach.

The Matsuno brothers try to adapt their show to contemporary times, with mixed results.

The Matsuno brothers struggle to find employment. Later, Osomatsu tries to take an interest in his brothers' lives but winds up being a nuisance to them.

A collection of unrelated shorts starring the wild and wacky cast of Osomatsu-san. A trip to outer space ends in disaster, the Pachinko Police are called in, and a familiar-looking puppet serial killer who can't seem to find the right sextuplet for his reverse-beartrap are among the skits featured.

The Matsuno brothers compete to ensure their divorcing parents will care of each of them. Meanwhile, Totoko asks the brothers for help in a crisis.

Karamatsu gets kidnapped, but his brothers don't do anything. Later, a cat gets to speak and read minds, which causes mayhem for the Matsuno brothers.

The Matsunos are invited to Hatabou's birthday part. / Iyami discovers that his buckteeth contain a rare metal.

Todomatsu gets a job at a local coffeehouse. His brothers want no such success. / Dekapan and Dayon enjoy a carefree northbound trip together.

Captain Choromatsu invites an interesting detective onto an increasingly dangerous murder case to ease the tension of the crew. / Totoko wants to be a popular idol, but reality is so cruel.

Karamatsu ends up as Chibita's apprentice at his oden stand. Meanwhile, Jyushimatsu falls in love and his brothers try to help him achieve his romance.

Iyami and Chibita dress up as girls, and trick the Matsuno brothers into falling in love with them with the help of a sex-change drug. It's only a matter of time before this plan goes bad.

A series of Christmas-themed skits. Among those included are a zombified cold open, Ichimatsu disturbing a happy couple on a date, an F6 holiday fantasy, and the Annual Matsuno Family Christmas Gift Exchange.

Osomatsu and Totoko host an end of year special broadcast, looking back on previous episodes to determine which of the brothers is the biggest loser.

A salaryman named Sanematsu takes care of his six siblings, the Matsuno brothers play the roles of a friend group of working girls, and Choromatsu gets caught during a private moment.

The sextuplets catch a resilient cold. Later, the brothers question Todomatsu about all the things he hasn't told them about his personal life. Afterwards, Choromatsu plays a paranoid vice-principal overly worried about plans for his school's cultural festival.

Jyushimatsu goes to a job interview, proving to be a total nuisance for the interviewers. Later, the Girlymatsus return to go on a ladies' trip, causing trouble for each other as they arrive. After, Chibita falls in love with a fairy who manifested from a lonely flower.

Ichimatsu gets a job interview at a cat cafe, but when in Rome, he does as the locals do. Later, in an apocalyptic world, F6 battles against Iyami and Dekapan, who are robbing the dry-skinned citizens of all of their lotion. After, Ichimatsu is forced to pretend to be Karamatsu after Osomatsu catches him trying on his clothes.

A series of Jyushimatsu-oriented skits, including the fifth-youngest defusing a bomb, having a late-night cup of noodles, selling baseball doujins at Comiket, and devolving the world into its written essentials.

Wanting to become the main protagonist of the franchise again, Iyami holds a bizarre kart race to determine who the protagonist of Osomatsu-san will be.

A series of skits take place, set during the Sengoku era. Back in the present, Choromatsu decides to quit being an idol-worshipper and pursue a job, with only his self-awareness standing in the way.

Hatabou starts his own catering service, cooking with a delicious mystery meat. Later, Osomatsu, Karamatsu, and the rest play delinquent high school students competing to see who's the toughest. Afterwards, Iyami starts a comedy class hoping to earn a quick buck.

On a rainy evening, the brothers play a fierce game of mahjong. Later, the brothers suddenly find themselves joined by a seventh brother, Kamimatsu, born from the goodness that fell out of the brothers' hearts.

Todomatsu holds auditions to take one of his brothers with him to a mixer, struggling to find anyone worth taking. Meanwhile, Iyami meets a kung-fu master who believes him to possess a special technique.